Nailfold video capillaroscopy as a useful diagnostic tool in systemic vasculitis

Keret, Shiri; Mazzawi, Jan; Slobodin, Gleb; Rimar, Ori; Rosner, Itzhak; Rozenbaum, Michael; Kaly, Lisa; Boulman, Nina; Awisat, Abid; Shouval, Aniela; Ingegnoli, Francesca; Rimar, Doron

doi:10.1016/j.mvr.2022.104406

Cited by 4 publications

(14 citation statements)

References 17 publications

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“…Capillary density: Evaluation of the number of capillaries per mm of distal row, normal capillary density varies from 9 to 14 capillaries per mm in adults and at least 6 in children. There were no significant density modifications detected in the activity phase and/or remission phase of AAV compared with the healthy control group [12]. Nevertheless, one study conducted on 10 patients with GPA revealed that one main alteration was a 75% lower capillary density [13].…”

Section: Capillaroscopic Phenotypesmentioning

confidence: 80%

“…Keret et al [12] 25 patients were examined via NVC, 17 with active vasculitis and 8 with vasculitis in remission. Among them, only 1 patient with active GPA, 3 with active EGPA, and 2 with active MPA.…”

Section: Capillaroscopic Strategy and Methods Capillaroscopy Findingsmentioning

confidence: 99%

“…Recently, there has been increased attention on the utility of the non-invasive microvascular inspection of the nailfold bed for several systemic diseases [12][13][14][15][16][17][18][19][20][21][22][23][24][25]. Precisely, nail bed capillaroscopy is useful for assessing subjects for potential scleroderma and other autoimmune diseases [26].…”

Section: Nailfold Video Capillaroscopymentioning

confidence: 99%

“…Furthermore, six studies documented higher rates of capillaroscopic abnormalities in AAV patients but generally non-specific alterations such as increased tortuosity, microhaemorrhages, enlarged and bizarre capillaries, and architectonic disarrangement. Cutolo et al [10] defined the latter when shapes, length, and diameter vary in continuous loops, which leads to a large alteration in the normal capillary pattern [12][13][14][16][17][18]. Two articles did not report any substantial differences in NVC scores between healthy subjects and AAV patients [15,19].…”

Section: Sullivan Et Almentioning

confidence: 99%

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Nailfold Capillaroscopy Analysis Can Add a New Perspective to Biomarker Research in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Screm,

Mondini,

Confalonieri

et al. 2024

Diagnostics

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Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) includes granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA), all of which are characterised by inflammation of small–medium-sized vessels. Progressive understanding of these diseases has allowed researchers and clinicians to start discussing nailfold video capillaroscopy (NVC) as a future tool for many applications in daily practice. Today, NVC plays a well-established and validated role in differentiating primary from secondary Raynaud’s phenomenon correlated with scleroderma. Nevertheless, there has not been sufficient attention paid to its real potential in the ANCA-associated vasculitis. In fact, the role of NVC in vasculitis has never been defined and studied in a multicentre and multinational study. In this review, we carried out a literature analysis to identify and synthesise the possible role of capillaroscopy for patients with ANCA-associated vasculitis. Methods: Critical research was performed in the electronic archive (PUBMED, UpToDate, Google Scholar, ResearchGate), supplemented with manual research. We searched in these databases for articles published until November 2023. The following search words were searched in the databases in all possible combinations: capillaroscopy, video capillaroscopy, nailfold-video capillaroscopy, ANCA-associated vasculitis, vasculitis, granulomatosis with polyangiitis, EGPA, and microscopic polyangiitis. Results: The search identified 102 unique search results. After the evaluation, eight articles were selected for further study. The literature reported that capillaroscopy investigations documented non-specific abnormalities in 70–80% of AAV patients. Several patients showed neoangiogenesis, capillary loss, microhaemorrhages, and bushy and enlarged capillaries as the most frequent findings. Furthermore, the difference between active phase and non-active phase in AAV patients was clearly discernible. The non-active phase showed similar rates of capillaroscopy alterations compared to the healthy subjects, but the active phase had higher rates in almost all common abnormalities instead. Conclusions: Microvascular nailfold changes, observed in patients affected by vasculitis, may correlate with the outcome of these patients. However, these non-specific abnormalities may help in the diagnosis of vasculitis. As such, new analysis analyses are necessary to confirm our results.

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Section: Capillaroscopic Phenotypesmentioning

confidence: 80%

Section: Capillaroscopic Strategy and Methods Capillaroscopy Findingsmentioning

confidence: 99%

Section: Nailfold Video Capillaroscopymentioning

confidence: 99%

Section: Sullivan Et Almentioning

confidence: 99%

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Nailfold Capillaroscopy Analysis Can Add a New Perspective to Biomarker Research in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Screm,

Mondini,

Confalonieri

et al. 2024

Diagnostics

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“…NV is also utilized in other connective tissue diseases, such as Raynaud's syndrome, mixed connective tissue disease, overlap syndromes, dermatomyositis, and polymyositis. [ 5 6 ]…”

mentioning

confidence: 99%

Proximal nailfold videocapillaroscopy findings of patients with idiopathic macular telangiectasia type 2

Gedik,

Erol,

Bulut

et al. 2023

Indian Journal of Ophthalmology

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Purpose: Idiopathic macular telangiectasia type 2 (IMT) is a neurodegenerative disease characterized by bilateral, idiopathic, and perifoveal retinal telangiectatic vessel formations. We aimed to compare proximal nailfold videocapillaroscopy (NV) findings between patients with IMT and healthy individuals and evaluate the optical coherence tomography angiography (OCTA) parameters of the patients with IMT according to their NV findings. Methods: The study included 43 patients with IMT and 92 healthy controls of similar age and gender without any additional diseases. The OCTA and NV findings of the patients and controls were examined. Results: The mean age was 59.76 ± 5.73 years in the IMT group and 58.23 ± 4.96 years in the control group. Of the 43 patients with IMT, 19 were found to have increased capillary tortuosity, six had microhemorrhage, and 18 had bizarre capillaries (P < 0.001). In the IMT group, the total vascular density value of the superficial capillary plexus was higher among the patients with capillary microhemorrhage (P = 0.001), and the subfoveal choroidal thickness was lower among those with increased capillary tortuosity and bizarre capillaries (P = 0.04 and P = 0.07, respectively). Conclusion: This is the first study in which the NV findings of patients with IMT were compared with those of a control group. We found higher rates of increased capillary tortuosity, microhemorrhage, and bizarre capillaries in the IMT group compared to the controls. We consider that this situation is caused by microvascular damage. We also think that IMT is a systemic disease that affects both proximal nailfold capillaries and eye vessels.

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Nailfold capillaroscopy reveals early peripheral microcirculation abnormalities in children affected by heterozygous familial hypercholesterolemia

Martino

Barilla'

Martino

et al. 2023

Microvascular Research

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Nailfold video capillaroscopy as a useful diagnostic tool in systemic vasculitis

Cited by 4 publications

References 17 publications

Nailfold Capillaroscopy Analysis Can Add a New Perspective to Biomarker Research in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Nailfold Capillaroscopy Analysis Can Add a New Perspective to Biomarker Research in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Proximal nailfold videocapillaroscopy findings of patients with idiopathic macular telangiectasia type 2

Nailfold capillaroscopy reveals early peripheral microcirculation abnormalities in children affected by heterozygous familial hypercholesterolemia

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