Nails in Systemic Disease

Lipner, Shari R.; Lawry, Monica; Kroumpouzos, George; Scher, Richard K.; Daniel, C. Ralph

doi:10.1007/978-3-319-65649-6_21

Cited by 3 publications

(6 citation statements)

References 248 publications

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“…A significant onychopathological indicator of chronic renal failure, Lindsay's nail, or the half-and-half nail can resemble this finding. The key to distinguishing between these phenomena may be the degree of orange discoloration that is found in COVID affected nails [ 9 ]. Furthermore, this finding may also be confused for pseudo half-and-half nails, a similar finding seen in patients with psoriasis [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

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Nail Manifestations in COVID-19: Insight into a Systemic Viral Disease

Preda-Naumescu

Penney

Pearlman

et al. 2021

Skin Appendage Disord

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Nail manifestations are 1 of the several extrapulmonary findings associated with COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nail changes, however, have been largely ignored and not yet summarized. This article is intended to increase awareness of nail manifestations of SARS-CoV-2, which occur weeks to months after acute infection and the periungual pernio-like changes may occur concomitantly with infection. An electronic search was carried out in PubMed (Medline), Science Direct, and Scopus databases. The following keywords and all of their possible combinations were used to identify studies: “SARS-CoV-2,” “COVID-19,” “Coronavirus,” “2019-ncov,” “nail,” and “nails.” Six case reports were included in this study. Manifestations identified included red half-moon sign, transverse orange nail lesions, Mees’ lines, and Beau’s lines. Though largely nonspecific, these findings can be recognized with the onset of symptom onset or as late as 16 weeks following the disease. Some of these findings are shared with other conditions associated with a proinflammatory state. Nail changes offer unique insight into the pathophysiologic basis for SARS-CoV-2 and they may serve as diagnostic clues.

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Section: Resultsmentioning

confidence: 99%

“…The key to distinguishing between these phenomena may be the degree of orange discoloration that is found in COVID affected nails [ 9 ]. Furthermore, this finding may also be confused for pseudo half-and-half nails, a similar finding seen in patients with psoriasis [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

Nail Manifestations in COVID-19: Insight into a Systemic Viral Disease

Preda-Naumescu

Penney

Pearlman

et al. 2021

Skin Appendage Disord

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“…Thyroid disease may rarely present with onycholysis in the form of Plummer's nails 29 . Finally, linear transversal onycholysis has been reported during pregnancy 28 …”

Section: Transversal Onycholysismentioning

confidence: 99%

“…27 Systemic conditions associated with linear transversal onycholysis include lupus erythematosus, amyloidosis and multiple myeloma, pellagra, anaemia, pemphigus vulgaris, porphyria cutanea tarda, and lung carcinoma. 28 Thyroid disease may rarely present with onycholysis in the form of Plummer's nails. 29 Finally, linear transversal onycholysis has been reported during pregnancy.…”

Section: Linear Transversal Onycholysismentioning

confidence: 99%

Pattern diagnosis of onycholysis

Navarro

2023

JEADV Clinical Practice

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Onycholysis is defined as the detachment of the nail plate from the underlying and/or lateral supporting structures. Trauma, inflammatory conditions, infectious agents, tumours and toxic substances are the most commonly reported causes of onycholysis. We review the main causes of onycholysis in clinical practice and provide a diagnostic approach based on morphologic patterns of the proximal border of onycholysis, as defined by clinical and dermoscopic examination. Four morphologic patterns of onycholysis, namely transversal, lateral, V-shaped and circular are presented with their most common causes and triggers.

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“…Nevertheless, it occurs idiopathically in otherwise healthy adults and is mainly induced by trauma. 3 Infectious diseases that cause septicemias such as meningococcemia or connective tissue disorders, systemic vasculitis, and certain drugs can also be responsible for splinter hemorrhages. 1 Chemotherapeutic agents, especially kinase inhibitors such as sunitinib and sorafenib, can induce splinter hemorrhages because of their anti-angiogenic effects.…”

mentioning

confidence: 99%