Naloxone differentially alters parental aggression by female mice towards conspecific intruders of differing sex

Parmigiani, Stefano; Rodgers, R.J.; Mainardi, Michele

doi:10.1002/1098-2337(1988)14:3<213::aid-ab2480140307>3.0.co;2-l

Cited by 15 publications

(1 citation statement)

References 33 publications

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“…Recent data in mice by Parmigiani, Rodgers, Palanza, and Mainardi (1988) indicate that opiates may modulate some forms of PPA. Naloxone, an opiate receptor antagonist, reduces PPA against a female but not a male intruder.…”

Section: Discussionmentioning

confidence: 99%

Morphine treatment and reproductive condition alter olfactory preferences for pup and adult male odors in female rats

Kinsley

Bridges

1990

Developmental Psychobiology

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Administration of morphine sulfate (MS) to pregnancy-terminated and postpartum lactating female rats disrupts both maternal behavior and postpartum aggression. Since the display of these behaviors may be heavily dependent on olfactory cues provided by the stimulus animals (rat pups and adult male rats, respectively), we examined whether MS was affecting the perception of the olfactory stimuli, and whether olfactory perception was modified by reproductive condition. In Experiment 1, lactating rats had their pups removed and were injected with MS (5.0 mg/kg, sc.) or saline. 60 min later they were placed into a two-choice apparatus, one side of which contained bedding soiled by neonates and the other clean bedding. Time spent on each side was recorded for a total of 5 min (300 s; chance = 150 s). Saline-treated mothers spent significantly more time on the pup-odor side, whereas MS-treated females spent significantly less. In Experiment 2, lactating females were treated with MS or saline and exposed to male odors (soiled bedding). MS significantly increased time spent on the side with male odors; when treated with saline, time spent was significantly reduced. Thus, in lactating rats. MS creates an aversion for pup odors while reducing the female's normal aversion toward male odors. In Experiment 3, ovariectomized (ovx) virgin females expressed neither an aversion nor a preference for the odor of pups following saline administration. After MS treatment, however, the virgins showed a distinct preference for pup odors. When exposed to male odors in Experiment 4 ovx virgins showed a marked preference for male odors after MS treatment, and neither a preference nor an aversion after saline. Experiment 5 examined pup odor preferences in intact virgins, early (Day 7), middle (Day 14), late-pregnant (Day 21), and prepartum (Day 22) rats. The pup odor preferences of virgin, Day 7, Day 14, and Day 21 pregnant rats were not different and generally were at chance levels. Day 22 pregnant females exhibited a marked preference for pup odors compared to chance levels, as well as compared to the other four groups. These findings suggest that opiates and endogenous opioids may regulate olfactory preferences and that alterations in this system may underlie normal behavioral changes toward conspecifics prepartum as well as during lactation.

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Section: Discussionmentioning

confidence: 99%

Morphine treatment and reproductive condition alter olfactory preferences for pup and adult male odors in female rats

Kinsley

Bridges

1990

Developmental Psychobiology

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A guide to the literature on aggressive behavior

1989

Aggr. Behav.

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Maternal aggression toward infanticidal males of different social status in wild house mice (Mus musculus domesticus)

Parmiglani¹,

Saal²

1994

Aggr. Behav.

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Maternal aggression was examined in wild female mice (Mus musculus domesticus) derived from animals trapped in Alberta, Canada. Lactating females were tested for their behavior toward intruder males during the time of postpartum estrus while housed in a two‐cage apparatus containing a defensible nest area. Prior to being used as intruders, sexually naive males were screened for their behavior toward a newborn pup (83% exhibited infanticide). Only infanticidal males were then housed in pairs and allowed to establish a dominance hierarchy. Dominance status was further verified by a urine marking test. The dominant and subordinate infanticidal males were then placed into a lactating female's cage and observed for 1 hr. The test was terminated immediately when a male began to attack the pups. Lactating females attacked the males in both groups, but subordinate males received more intense attacks than dominant males. Dominant males elicited significantly more fear/defense behavior than subordinate intruders. All of the dominant males and only one submissive male attacked the pups. Females were thus successful in blocking infanticide only by infanticidal subordinate males. Since females do not persist in attacking males with high fighting ability, one function of maternal aggression could be to assess the fighting, and resource holding, potential of a future mate. © 1994 Wiley‐Liss, Inc.

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Naloxone differentially alters parental aggression by female mice towards conspecific intruders of differing sex

Cited by 15 publications

References 33 publications

Morphine treatment and reproductive condition alter olfactory preferences for pup and adult male odors in female rats

Morphine treatment and reproductive condition alter olfactory preferences for pup and adult male odors in female rats

A guide to the literature on aggressive behavior

Maternal aggression toward infanticidal males of different social status in wild house mice (Mus musculus domesticus)

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