Naloxone does not attenuate the locomotor effects of ethanol in FAST, SLOW, or two heterogeneous stocks of mice

Holstein, Sarah E.; Pastor, Raúl; Meyer, Paul J.; Phillips, Tamara J.

doi:10.1007/s00213-005-0066-8

Cited by 13 publications

(18 citation statements)

References 72 publications

(99 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All testing occurred between 0800 and 1600 h, and room lighting intensity was similar in the activity testing room and colony rooms. Subjects were not habituated to the activity monitor or to injections prior to locomotor testing, consistent with previous studies from our laboratory for both ethanol- (Phillips et al, 1991) and morphine-induced locomotor stimulation (Bergstrom et al, 2003;Holstein et al, 2005;Phillips et al, 1992), as well as for baclofeninduced modulation of ethanol stimulation in FAST mice (Shen et al, 1998). Details specific to each experiment are given below.…”

Section: Methodsmentioning

confidence: 71%

“…Quite unexpectedly (see Bergstrom et al, 2003;Holstein et al, 2005), no locomotor stimulant response was seen to the 32 mg/kg morphine dose in FAST-2 mice. However, as seen in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Each subject was then given an injection of 32 mg/kg morphine or an equivalent volume of saline and locomotor activity was recorded for 30 min in 5-min time bins. A 32 mg/kg dose of morphine was chosen as it had previously been found to produce the maximal line difference for locomotor activity between the FAST and SLOW selected lines (Bergstrom et al, 2003;Holstein et al, 2005).…”

Section: Methodsmentioning

confidence: 99%

“…Specifically, opioid receptor agonists increase dopaminergic activity by binding to inhibitory opioid receptors located on GABAergic neurons within the VTA, resulting in a disinhibition of dopamine neurons (Johnson and North, 1992). A similar opioidergic mechanism has been suggested to mediate locomotor stimulation to ethanol (see Gianoulakis et al, 2004); however, the nonspecific opioid receptor antagonist naloxone failed to alter the locomotor stimulant effects of ethanol in FAST mice or the locomotor depressant effects in SLOW mice, suggesting that a selectioninduced alteration in endogenous opioidergic systems may not be responsible for the genetically correlated response to ethanol and morphine in FAST and SLOW mice (Holstein et al, 2005).…”

Section: Introductionmentioning

confidence: 93%

“…Boehm et al, 2002;Castelli et al, 2005;Chester and Cunningham, 1999;Leite-Morris et al 2002, 2004Shen et al, 1998;Tsuji et al, 1996;Woo et al, 2001). The FAST and SLOW selected mouse lines, which were bred, in replicate, for heightened and reduced sensitivity to the locomotor stimulant effects of ethanol (Crabbe et al, 1987;Phillips et al, 1991;Shen et al, 1995b), also differ in their locomotor response to morphine (Bergstrom et al, 2003;Holstein et al, 2005). This genetic correlation suggests that some of the same alleles that influence sensitivity to the selection trait (ethanol-induced locomotion), and thus some common neurobiological mechanisms, contribute to sensitivity to the locomotor effects of morphine (see Crabbe et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

GABAB receptor stimulation accentuates the locomotor effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol

Holstein

Phillips²

2006

Pharmacology Biochemistry and Behavior

Self Cite

View full text Add to dashboard Cite

Mice selectively bred for divergent sensitivity to the locomotor stimulant effects of ethanol (FAST and SLOW) also differ in their locomotor response to morphine. The GABA B receptor has been implicated in the mediation of locomotor stimulation to both ethanol and morphine, and a reduction in ethanol-induced stimulation has been found with the GABA B receptor agonist baclofen in FAST mice. We hypothesized that GABA B receptor activation would also attenuate the locomotor stimulant responses to morphine in these mice. In order to test this hypothesis, baclofen was administered to FAST-1 and FAST-2 mice 15 min prior to morphine, and activity was recorded for 30 min. Baclofen attenuated stimulation to 32 mg/kg morphine in FAST-1 mice, but only at a dose that also reduced saline activity. There was no stimulant response to 32 mg/kg morphine in FAST-2 mice, or to 16 mg/kg or 48 mg/kg morphine in FAST-1 mice, but the combination of baclofen with these morphine doses accentuated locomotor activity. Therefore, it appears that GABA B receptor activation is not a common mechanism for the locomotor stimulant responses to ethanol and morphine in FAST mice; however, these data suggest that GABA B receptor activation may instead enhance some of the behavioral effects of morphine.

show abstract

Section: Methodsmentioning

confidence: 71%

“…Quite unexpectedly (see Bergstrom et al, 2003;Holstein et al, 2005), no locomotor stimulant response was seen to the 32 mg/kg morphine dose in FAST-2 mice. However, as seen in Fig.…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

GABAB receptor stimulation accentuates the locomotor effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol

Holstein

Phillips²

2006

Pharmacology Biochemistry and Behavior

Self Cite

View full text Add to dashboard Cite

show abstract

Selective mu- and kappa-opioid receptor antagonists administered into the nucleus accumbens interfere with rapid tolerance to ethanol in rats

Varaschin

Morato

2009

Psychopharmacology

View full text Add to dashboard Cite

show abstract

Intracranial self-stimulation in FAST and SLOW mice: effects of alcohol and cocaine

et al. 2011

Self Cite

View full text Add to dashboard Cite

Rationale Sensitivity to the stimulant and rewarding effects of alcohol may be genetically-correlated traits that predispose individuals to developing an alcohol use disorder. Objective To examine the effects of alcohol and cocaine on intracranial self-stimulation (ICSS) in FAST and SLOW mice, which were selectively bred for extremes in alcohol stimulation. Methods Male FAST and SLOW mice were conditioned to respond for reinforcement by direct electrical stimulation of the medial forebrain bundle (i.e. brain stimulation-reward or BSR). ICSS responses were determined immediately before and after oral gavage with water or alcohol (0.3 – 2.4 g/kg) or intraperitoneal injection with saline or cocaine (1.0 – 30.0 mg/kg). In separate FAST and SLOW mice, the locomotor effects of these treatments were measured in activity chambers. Results Alcohol dose-dependently lowered the threshold for self-stimulation (θ0) and the frequency that maintained 50% of maximal responding (EF50) in FAST mice but did not significantly affect these parameters in SLOW mice. The largest effects of alcohol were after the 1.7 and 2.4 g/kg doses and were about 40% compared to water injection. Alcohol did not affect MAX response rates, but dose-dependently stimulated locomotor activity in FAST mice. Cocaine lowered thresholds equally in FAST and SLOW mice, although cocaine- stimulated locomotor activity was higher in the FAST than in the SLOW mice. Conclusions Selective breeding for alcohol locomotor stimulation also renders the mice more sensitive to the effects of alcohol, but not cocaine, on ICSS.

show abstract

Naloxone does not attenuate the locomotor effects of ethanol in FAST, SLOW, or two heterogeneous stocks of mice

Cited by 13 publications

References 72 publications

GABAB receptor stimulation accentuates the locomotor effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol

GABAB receptor stimulation accentuates the locomotor effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol

Selective mu- and kappa-opioid receptor antagonists administered into the nucleus accumbens interfere with rapid tolerance to ethanol in rats

Intracranial self-stimulation in FAST and SLOW mice: effects of alcohol and cocaine

Contact Info

Product

Resources

About