Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture

Guimarães, Ana Paula Franttini Garcia Moreno; Butezloff, Mariana Maloste; Zamarioli, Ariane; Issa, João Paulo Mardegan; Volpon, José Batista

doi:10.1590/s0102-865020170110000004

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…Flicker et al (15) observed a significant increase in bone mineral content in osteopenic females treated with ND, and considering the potential physiological differences of the species, it is suggested that treatment with ND increases bone mineral content, regardless of sex, in rabbits. Guimarães et al (16) evaluated the influence of ND on bone quality through the evaluation of BMD in male rats after 28 days of treatment and found no significant differences between the treated and control groups. From this, we derive another hypothesis that the beneficial effects of ND may occur later than expected.…”

Section: Discussionmentioning

confidence: 99%

Effect of nandrolone decanoate on healing of experimentally induced radial nonunion in rabbits (Oryctolagus cuniculus)

Dissenha

Minto²,

Calciolari

et al. 2021

Preprint

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The aim of this study was to evaluate the effect of nandrolone decanoate (ND) on treatment of bone nonunion in the radius of rabbits. Thirty-one, young adult, New Zealand White rabbits (Oryctolagus cuniculus) were allocated to one of four groups: nandrolone males (NMG), nandrolone females (NFG), placebo males (NPM), and placebo females (NPF). After bone nonunion of a 10 mm ostectomy of the radius was confirmed (45 days after surgery), the animals in the NMG and NFG groups received 10 mg/kg ND intramuscular once a week for four weeks, while placebo groups received intramuscular 0.9% NaCl solution. Radiographic, histopathologic, and densitometric parameters (DXA) were used to compared groups. Results: No significant differences were observed radiographically. However, ND groups showed greater area (P=0.0258) and BMC (P=0.0140) in the densitometric evaluation. Histologically, the placebo group showed a predominance of primary bone tissue. Whereas, lamellary organizations of secondary bone and the presence of fibrocartilage were found in the ND group (P =0.006). In conclusion, ND promoted bone regeneration after the creation of a large defect in the radius of rabbits.

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Section: Discussionmentioning

confidence: 99%

Effect of nandrolone decanoate on healing of experimentally induced radial nonunion in rabbits (Oryctolagus cuniculus)

Dissenha

Minto²,

Calciolari

et al. 2021

Preprint

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“…AAS and androgens are generally involved in bone growth and maintenance of bone homeostasis [ 108 ]. Studies show that anabolics do not affect bone quality, but speed up the strengthening process and increase bone callus formation after injury [ 124 ]. Souza et al [ 125 ] described that after administration of nandrolone decanolate, there was no increase in femoral weight or length and there was no difference in relation to the diameter of the epiphysis and the diaphysis.…”

Section: Effect Of Anabolic Steroids On Tissuesmentioning

confidence: 99%

Anabolic Steroids in Fattening Food-Producing Animals—A Review

Skoupá

Šťastný

Sládek

2022

Animals

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Anabolic steroids are chemically synthetic derivatives of the male sex hormone testosterone. They are used in medicine for their ability to support muscle growth and healing and by athletes for esthetic purposes and to increase sports performance, but another major use is in fattening animals to increase meat production. The more people there are on Earth, the greater the need for meat production and anabolic steroids accelerate the growth of animals and, most importantly, increase the amount of muscle mass. Anabolic steroids also have proven side effects that affect all organs and tissues, such as liver and kidney parenchymal damage, heart muscle degeneration, organ growth, coagulation disorders, and increased risk of muscle and tendon rupture. Anabolic steroids also have a number of harmful effects on the developing brain, such as brain atrophy and changes in gene expression with consequent changes in the neural circuits involved in cognitive functions. Behavioral changes such as aggression, irritability, anxiety and depression are related to changes in the brain. In terms of long-term toxicity, the greatest impact is on the reproductive system, i.e., testicular shrinkage and infertility. Therefore, their abuse can be considered a public health problem. In many countries around the world, such as the United States, Canada, China, Argentina, Australia, and other large meat producers, the use of steroids is permitted but in all countries of the European Union there is a strict ban on the use of anabolic steroids in fattening animals. Meat from a lot of countries must be carefully inspected and monitored for steroids before export to Europe. Gas or liquid chromatography methods in combination with mass spectrometry detectors and immunochemical methods are most often used for the analysis of these substances. These methods have been considered the most modern for decades, but can be completely ineffective if they face new synthetic steroid derivatives and want to meet meat safety requirements. The problem of last years is the application of “cocktails” of anabolic substances with very low concentrations, which are difficult to detect and are difficult to quantify using conventional detection methods. This is the reason why scientists are trying to find new methods of detection, mainly based on changes in the structure of tissues and cells and their metabolism. This review gathered this knowledge into a coherent form and its findings could help in finding such a combination of changes in tissues that would form a typical picture for evidence of anabolic misuse.

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“…It increased the concentration of serum alkaline phosphatase, raised the serum level of phosphorus, and reduced the serum cholesterol level (Komrakova et al 2020). Unlike Ostarine, the commonly used anabolic-androgenic steroid nandrolone decanoate induced femoral fracture in rats after an intake of twenty-seven days, stimulated to a less extent the formation of callus and had no effect on the intact part of the bone (Guimarães et al 2017). On the other hand, the selective androgen receptor modulator S-4 reduced the expected loss of bone substance in an osteoporosis model in rats maintaining bone mineral density and enhancing bone strength (Kearbey et al 2007).…”

Section: Effects On Bonesmentioning

confidence: 99%

Untitled

2021

AJSPO

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ATINER is an Athens-based World Association of Academics and Researchers based in Athens.ATINER is an independent and non-profit Association with a Mission to become a forum where Academics and Researchers from all over the world can meet in Athens, exchange ideas on their research and discuss future developments in their disciplines, as well as engage with professionals from other fields. Athens was chosen because of its long history of academic gatherings, which go back thousands of years to Plato"s Academy and Aristotle"s Lyceum. Both these historic places are within walking distance from ATINER"s downtown offices. Since antiquity, Athens was an open city. In the words of Pericles, Athens"…is open to the world, we never expel a foreigner from learning or seeing". ("Pericles" Funeral Oration", in Thucydides, The History of the Peloponnesian War). It is ATINER"s mission to revive the glory of Ancient Athens by inviting the World Academic Community to the city, to learn from each other in an environment of freedom and respect for other people"s opinions and beliefs. After all, the free expression of one"s opinion formed the basis for the development of democracy, and Athens was its cradle. As it turned out, the Golden Age of Athens was in fact, the Golden Age of the Western Civilization. Education and (Re)searching for the "truth" are the pillars of any free (democratic) society. This is the reason why Education and Research are the two core words in ATINER"s name.

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Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture

Cited by 8 publications

References 35 publications

Effect of nandrolone decanoate on healing of experimentally induced radial nonunion in rabbits (Oryctolagus cuniculus)

Effect of nandrolone decanoate on healing of experimentally induced radial nonunion in rabbits (Oryctolagus cuniculus)

Anabolic Steroids in Fattening Food-Producing Animals—A Review

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