Nano- and Microsized Forms of Silymarin and Silybin

Silybin and its congeners: from traditional medicine to molecular effects

“…Various technological approaches are used to improve the solubility and oral bioavailability of silymarin components. [54][55][56][57][58][59][60][61][62] For example, using a nanostructured lipid carriers silymarin form, signicantly higher (12.46 fold) brain silybin concentration was achieved. 62 A linear relationship between oral silymarin dose and maximum silybin plasma concentration (C max ) was found in human volunteers, but not in animal models (rat, rabbit, and dog).…”