Nano-biosensor for the in vitro lactate detection using bi-functionalized conducting polymer/N, S-doped carbon; the effect of αCHC inhibitor on lactate level in cancer cell lines

Hussain, Khalil K.; Gurudatt, N.G.; Akhtar, Mahmood Hassan; Seo, Kyeong‐Deok; Park, Deog-Su; Shim, Yoon‐Bo

doi:10.1016/j.bios.2020.112094

Cited by 29 publications

(15 citation statements)

References 30 publications

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“…While only lactate was monitored, the general principle can be extended to other metabolites to reach a deeper understanding of cancer evolution. Hussain et al developed an amperometric sensor for lactate and conducted measurements in the extracellular media of cancer and noncancerous cells (MCF-7 and HeLa, Vero cells, respectively) . The porous carbon electrode surface was functionalized by sequentially conjugating nicotinamide adenine dinucleotide (NAD + ) onto the carboxylic acid group and lactate dehydrogenase (LDH) onto the amine group of a bifunctionalized conducting polymer (poly-3-((2,2′:50,200-terthiophen)-30-yl)-5-aminobenzoic acid, pTTABA).…”

Section: Applicationsmentioning

confidence: 99%

Organic Bioelectronic Devices for Metabolite Sensing

et al. 2021

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Electrochemical detection of metabolites is essential for early diagnosis and continuous monitoring of a variety of health conditions. This review focuses on organic electronic material-based metabolite sensors and highlights their potential to tackle critical challenges associated with metabolite detection. We provide an overview of the distinct classes of organic electronic materials and biorecognition units used in metabolite sensors, explain the different detection strategies developed to date, and identify the advantages and drawbacks of each technology. We then benchmark state-of-the-art organic electronic metabolite sensors by categorizing them based on their application area (in vitro, bodyinterfaced, in vivo, and cell-interfaced). Finally, we share our perspective on using organic bioelectronic materials for metabolite sensing and address the current challenges for the devices and progress to come. CONTENTS 1. Introduction 4581 2. Metabolite Sensing in the Body at a Glance 4583 2.1. Metabolite Sensing and Signaling Mechanisms: Sensor−Transducer−Effector Model 4583 2.2. (Biological) Recognition Units 4584 3. Organic Electronic Materials in Metabolite Sensing 4588 3.1. Graphene 4588 3.2. Carbon Nanotubes 4590 3.3. Conjugated Polymers (CPs) 4590 3.4. Composite Materials 4591 4. Sensing Methods 4592 4.1. Electrodes 4593 4.1.1.

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Section: Applicationsmentioning

confidence: 99%

Organic Bioelectronic Devices for Metabolite Sensing

et al. 2021

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“…EDC/NHS (ethyl(dimethylaminopropyl) carbodiimide/ N -Hydroxysuccinimide), TTABA monomer ((poly 3-(((2,2′:5′,2″-terthiophen)-3′-yl)-5-aminobenzoic acid). Image reprinted with permission from [ 161 ] Copyrights (2020), Elsevier.…”

Section: Materials Considerations In Wearable Biosensorsmentioning

confidence: 99%

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

et al. 2021

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In the past decade, wearable biosensors have radically changed our outlook on contemporary medical healthcare monitoring systems. These smart, multiplexed devices allow us to quantify dynamic biological signals in real time through highly sensitive, miniaturized sensing platforms, thereby decentralizing the concept of regular clinical check-ups and diagnosis towards more versatile, remote, and personalized healthcare monitoring. This paradigm shift in healthcare delivery can be attributed to the development of nanomaterials and improvements made to non-invasive biosignal detection systems alongside integrated approaches for multifaceted data acquisition and interpretation. The discovery of new biomarkers and the use of bioaffinity recognition elements like aptamers and peptide arrays combined with the use of newly developed, flexible, and conductive materials that interact with skin surfaces has led to the widespread application of biosensors in the biomedical field. This review focuses on the recent advances made in wearable technology for remote healthcare monitoring. It classifies their development and application in terms of electrochemical, mechanical, and optical modes of transduction and type of material used and discusses the shortcomings accompanying their large-scale fabrication and commercialization. A brief note on the most widely used materials and their improvements in wearable sensor development is outlined along with instructions for the future of medical wearables.

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“…Its electrocatalytic properties can be further enhanced by doping carbon with heteroatoms like B (boron), N (nitrogen) or S (sulfur). The detection of neurotransmitters and lactic acid is feasible using the composites of N and S doped carbon with polymers like poly 3-((2,2 :5 ,2"-terthiophen)-3 -yl)-5-aminobenzoic acid (pTTABA)) and 2, 2 :5 ,5"-terthiophene-3 -p-benzoic acid (TBA) [99,100]. The core-shell nanocomposite of Pt-Pd with N-doped carbon shell acetylcholine biosensor is fabricated for organophosphate pesticide detection in "real-world" samples.…”

Section: Conducting Polymer Compositesmentioning

confidence: 99%

Recent Advances of Conducting Polymers and Their Composites for Electrochemical Biosensing Applications

Luong

Narayan

Solanki

et al. 2020

JFB

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Conducting polymers (CPs) have been at the center of research owing to their metal-like electrochemical properties and polymer-like dispersion nature. CPs and their composites serve as ideal functional materials for diversified biomedical applications like drug delivery, tissue engineering, and diagnostics. There have also been numerous biosensing platforms based on polyaniline (PANI), polypyrrole (PPY), polythiophene (PTP), and their composites. Based on their unique properties and extensive use in biosensing matrices, updated information on novel CPs and their role is appealing. This review focuses on the properties and performance of biosensing matrices based on CPs reported in the last three years. The salient features of CPs like PANI, PPY, PTP, and their composites with nanoparticles, carbon materials, etc. are outlined along with respective examples. A description of mediator conjugated biosensor designs and enzymeless CPs based glucose sensing has also been included. The future research trends with required improvements to improve the analytical performance of CP-biosensing devices have also been addressed.

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Nano-biosensor for the in vitro lactate detection using bi-functionalized conducting polymer/N, S-doped carbon; the effect of αCHC inhibitor on lactate level in cancer cell lines

Cited by 29 publications

References 30 publications

Organic Bioelectronic Devices for Metabolite Sensing

Organic Bioelectronic Devices for Metabolite Sensing

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

Recent Advances of Conducting Polymers and Their Composites for Electrochemical Biosensing Applications

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