Nano-biosensors based on dynamic light scattering

Levin, A. D.; Nikitin, Maxim P.; Alenichev, M. K.; Drozhzhennikova, E. B.; Grigorenko, G.M.; Ringaci, A.; Андреева, И. П.

doi:10.1117/12.2526055

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…• Based on the dimension: The nanobiosensor products can be classified into three categories based on the dimensions which are pushed to the nanometer scale: a. [63], [64] Optical absorption-based nanobiosensors [65] Fluorescent nanobiosensors [66], [67] Light scattering nanobiosensors [68], [69] Surface plasmon resonance (SPR) based nanobiosensors [70], [71] Surface-enhanced Raman scattering (SERS) nanobiosensors [72], [73] Inductively coupled plasma mass spectroscopy (ICP-MS) nanobiosensors [74], [75] • Ultrahigh sensitivity: Use of nanotechnology has made biosensors more adept in terms of detection capability and sensitivity.…”

Section: ) Classifications Of Nanobiosensorsmentioning

confidence: 99%

Advancing Modern Healthcare With Nanotechnology, Nanobiosensors, and Internet of Nano Things: Taxonomies, Applications, Architecture, and Challenges

Pramanik

Solanki

Debnath³

et al. 2020

IEEE Access

122

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Healthcare sector is probably the most benefited from the applications of nanotechnology. The nanotechnology, in the forms of nanomedicine, nanoimplants, nanobiosensors along with the internet of nano things (IoNT), has the potential to bring a revolutionizing advancement in the field of medicine and healthcare services. The primary aim of this paper is to explore the clinical and medical possibilities of these different implementations of nanotechnology. This paper provides a comprehensive overview of nanotechnology, biosensors, nanobiosensors, and IoNT. Furthermore, multilevel taxonomies of nanotechnology, nanoparticles, biosensors, nanobiosensors, and nanozymes are presented. The potential medical and clinical applications of these technologies are discussed in details with several examples. This paper specifically focuses on IoNT and its role in healthcare. In addition to describing a general architecture of IoNT for healthcare, the communication architecture of the IoNT is also explained. The challenges in the successful realization of IoNT are also discussed critically, along with a special discussion on internet of bio-nano things (IoBNT) and its potential in making IoNT more compatible to human body.

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Section: ) Classifications Of Nanobiosensorsmentioning

confidence: 99%

Advancing Modern Healthcare With Nanotechnology, Nanobiosensors, and Internet of Nano Things: Taxonomies, Applications, Architecture, and Challenges

Pramanik

Solanki

Debnath³

et al. 2020

IEEE Access

122

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“…The depolarized dynamic light scattering (DDLS) method is often used for the nanoparticle rotational diffusion study [22][23][24][25]. DDLS technique supposes the measurement of two components of the scattered light intensity-VV and VH that linear polarization directions are correspondingly coincide and perpendicular to the linear polarization direction of the incidence light.…”

Section: Observation Of Nanoparticles Rotational Diffusion Evolutionmentioning

confidence: 99%

Depolarized dynamic light scattering nanosensing based on aggregation-induced slowing-down of nanoparticles rotational diffusion

Levin¹,

Alenichev²,

Nagaev³

et al. 2019

Laser Phys. Lett.

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The intensity fluctuations of the depolarized component of laser light scattered by the optically anisotropic nanoparticles contain significant information on the rotational diffusion of particles. A high size-sensitivity of nanoparticle rotational diffusion in solution has a potential for monitoring of the biospecific aggregation of functionalized nanoparticles for biosensing applications. Here we demonstrate a new approach for determination of the target analytes such as proteins and other biomolecules using optical nanosensors based on dynamic light scattering (DLS). The proposed detection principle is based on the significant decrease of the rotation diffusion coefficient due to the nanoparticle aggregation. The decrease of the rotational diffusion is measured using intensity autocorrelation functions (IACF) from partially depolarized DLS. The criteria of the relative decrease of the rotational diffusion using the difference of IACF integrals from blank and analyte are proposed. The nanosensor prototypes based on gold nanospheres functionalized by antibodies to cancer markers were designed and validated using the proposed principle. Significant improvement of the sensor sensitivity as compared with the conventional hydrodynamic diameter determination was demonstrated.

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Development of optical nanosensors based on dynamic light scattering and fluorescence and detection devices for them

Sadagov

Alenichev

Drozhzhennikova

et al. 2019

J. Phys.: Conf. Ser.

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Nano-biosensors based on dynamic light scattering

Cited by 4 publications

References 26 publications

Advancing Modern Healthcare With Nanotechnology, Nanobiosensors, and Internet of Nano Things: Taxonomies, Applications, Architecture, and Challenges

Advancing Modern Healthcare With Nanotechnology, Nanobiosensors, and Internet of Nano Things: Taxonomies, Applications, Architecture, and Challenges

Depolarized dynamic light scattering nanosensing based on aggregation-induced slowing-down of nanoparticles rotational diffusion

Development of optical nanosensors based on dynamic light scattering and fluorescence and detection devices for them

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