Nano Copper Catalyzed Microwave Assisted Coupling of Benzene Boronic Acids with Thiophenols

Abstract

A proficient, microwave mediated methodology using CuFe2O4 nanoparticle as the catalyst for S-arylation of substituted benzene boronic acids with thiophenol has been developed. In this method, the substituted thioethers were easily obtained through a C-S bond formation using microwave irradiation technique as well as conventional heating in the presence of CuFe2O4 nanoparticles with modest to excellent yields with the less reaction time. The ligand free microwave technique helped in the preparation of substituted thioethers in measurable amount within 10 mins. The same results were obtained with conventional heating in 12h. The reported method is economically efficient and an alternative to the initial existing method for the preparation of substituted thioethers.

Nickel-Catalyzed Decarbonylative Thioetherification of Carboxylic Acids with Thiols

“…Transition-metal-catalyzed cross-couplings based on organohalides and pseudohalides, namely, Ullmann-type reactions, are also extensively used for thioether’s synthesis . New and efficient methods of forming thioethers are still highly desirable in organic synthetic community now …”

Metal-free photo-induced sulfidation of aryl iodide and other chalcogenation

“…( Ichiishi et al, 2018 ; Bie et al, 2021 ; Han Cao et al, 2021 ; Liu and Szostak, 2021 ) Reduction of sulfoxides also serves as a direct route to sulfides ( Shiri and Kazemi, 2017 ; Lin et al, 2021 ; Zhang 2022 ). The synthesis of aryl sulfides using phenylboronic acid as substrate requires the participation of magnetic nanoparticles or expensive transition metals ( Xu et al, 2012 ; Rostami et al, 2015a ; Rostami et al, 2015b ; Amiri et al, 2016a ; Amiri et al, 2016b ; Rostami et al, 2017 ; Wang et al, 2017 ; Cheng et al, 2018 ; Farzin et al, 2018 ; Atashkar et al, 2019 ; Gavhane et al, 2019 ; Khakyzadeh et al, 2019 ). With the development of photocatalytic reaction, photocatalytic synthesis of aryl sulfide has become an effective way.…”