With the improvement of micromanufacturing technology and the further elucidation of the propulsion mechanism, the manufacture and application of micro/nanomotors have made great progress. However, the application of micro/nanomotors in translational medicine is still in its infancy, and the promise of its research remains to be fully realized. In this paper, the preparation status of micro/nanomotors and their application prospects in translational medicine were reviewed. The representative micro/nanomotors and their clinical application value were introduced. In addition, this paper also analyzes the possible reasons for the low clinical conversion rate of micro/nanomotors and proposes the current challenges and future prospects to indicate a direction for their translational application in medicine.