Nano-embedded microparticles based dry powder inhaler for lung cancer treatment

Chishti, Nazimuddin; Dehghan, Mohamed Hassan

doi:10.35333/jrp.2020.165

Cited by 5 publications

(4 citation statements)

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“…In some cases, the approach invented for SLNas aims to be transferred to other materials. For example, Chishti and Dehghan [ 141 ] used the same strategy to obtain PLGA NPs of around 200 nm diameters by single emulsification assisted by sonification. Then they created their assemblies to the right size for alveolar accumulation by spray drying ( Fig.…”

Section: Novel Approachesmentioning

confidence: 99%

“… SEM images of inhalable composite NPs embedded within MPs: ( A ) Azi/NAC, ( B ) Cipro/NAC, ( C ) Tobr/NAC [ 143 ]; ( D ) lactose monohydrate based Trojan NPs, ( E ) trehalose-based Trojan NPs, ( F ) raffinose-based Trojan NPs [ 144 ]; ( G ) chitosan NPs/lactose-PEG3000 [ 145 ]; (H) PLGA/PLGA [ 141 ]; and (I) PLGA/mannitol [ 142 ]. All the pictures adapted with permission.…”

Section: Novel Approachesmentioning

confidence: 99%

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Inhalable microparticles as drug delivery systems to the lungs in a dry powder formulations

Knap

Kwiecień

Reczyńska-Kolman

et al. 2022

Regenerative Biomaterials

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Inhalation-administrated drugs remain an interesting possibility of addressing pulmonary diseases. Direct drug delivery to the lungs allows one to obtain high concentration in the site of action with limited systemic distribution, leading to a more effective therapy with reduced required doses and side effects. On the other hand, there are several difficulties in obtaining a formulation that would meet all the criteria related to physicochemical, aerodynamic, and biological properties, which is the reason why only very few of the investigated systems can reach the clinical trial phase and proceed to everyday use as a result. Therefore, we focused on powders consisting of polysaccharides, lipids, proteins, or natural and synthetic polymers in the form of microparticles that are delivered by inhalation to the lungs as drug carriers. We summarized the most common trends in research today to provide the best dry powders in the right fraction for inhalation that would be able to release the drug before being removed by natural mechanisms. This review paper addresses the most common manufacturing methods with novel modifications, pros and cons of different materials, drug loading capacities with release profiles, and biological properties such as cytocompatibility, bactericidal, or anticancer properties.

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Section: Novel Approachesmentioning

confidence: 99%

Section: Novel Approachesmentioning

confidence: 99%

Inhalable microparticles as drug delivery systems to the lungs in a dry powder formulations

Knap

Kwiecień

Reczyńska-Kolman

et al. 2022

Regenerative Biomaterials

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“…Therefore, the preparation of inhalable IBU nanoparticles with increased dissolution may be used as an alternative formulation approach for the targeted delivery of IBU to the lungs. [ 20 , 21 , 22 ]. Literature exists about the micronization and nanonization of IBU, but mostly to enhance its water-solubility and basically for oral application [ 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Ibuprofen Containing Nano-Embedded-Microparticles for Pulmonary Delivery

et al. 2023

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A fatal hereditary condition, cystic fibrosis (CF) causes severe lung problems. Ibuprofen (IBU), a non-steroidal anti-inflammatory drug, slows the progression of disease without causing significant side effects. Considering the poor water-solubility of the drug, IBU nanoparticles are beneficial for local pulmonary administration. We aimed to formulate a carrier-free dry powder inhaler containing nanosized IBU. We combined high-performance ultra-sonication and nano spray-drying. IBU was dissolved in ethyl acetate; after that, it was sonicated into a polyvinyl alcohol solution, where it precipitated as nanoparticles. Mannitol and leucine were added when producing dry particles using nano-spray drying. The following investigations were implemented: dynamic light scattering, laser diffraction, surface tension measurement, scanning electron microscopy, X-ray powder diffraction, differential scanning calorimetry, Fourier-transform infrared spectroscopy, in vitro dissolution test, and in vitro aerodynamic assessment (Andersen Cascade Impactor). The particle diameter of the IBU was in the nano range. The spray-dried particles showed a spherical morphology. The drug release was rapid in artificial lung media. The products represented large fine particle fractions and proper aerodynamic diameters. We successfully created an inhalable powder, containing nano-sized IBU. Along with the exceptional aerodynamic performance, the ideal particle size, shape, and drug-release profile might offer a ground-breaking local therapy for CF.

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“…Unwanted particle deposition in the upper area might have regional negative effects, such as localized discomfort, coughing, dysphonia, and infections [ 10 ]. Controlling the theoretical aerodynamic diameter at 1–5 µm is required for the successful transport of particles via the pulmonary route to the desired area in the lungs [ 11 ]. In the lower parts, regional deposition is also critical for effective drug delivery [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Physico-Chemical Stability and Aerodynamic Properties of Novel “Nano-in-Micro” Structured Dry Powder Inhaler System

Party

Ambrus

2023

Micromachines

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Pulmonary drug transport has numerous benefits. Large surface areas for absorption and limited drug degradation of the gastrointestinal system are provided through the respiratory tract. The administration is painless and easy for the patient. Due to their better stability when compared to liquid formulations, powders have gained popularity among pulmonary formulations. In the pharmaceutical sector, quality assurance and product stability have drawn a lot of attention. Due to this, it was decided to perform a long-term stability study on a previously developed, nanosized dry powder inhaler (DPI) formulation that contained meloxicam. Wet milling was implemented to reduce the particle size, and nano spray-drying was used to produce the extra-fine inhalable particles. The particle diameter was determined using dynamic light scattering and laser diffraction. Scanning electron microscopy was utilized to describe the morphology. X-ray powder diffraction and differential scanning calorimetry were applied to determine the crystallinity. In an artificial lung medium, the in vitro dissolution was studied. The Andersen Cascade Impactor was used to investigate the in vitro aerodynamic characteristics. The stability test results demonstrated that the DPI formulation maintained its essential qualities after 6 and 12 months of storage. Consequently, the product might be promising for further studies and development.

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Nano-embedded microparticles based dry powder inhaler for lung cancer treatment

Cited by 5 publications

References 0 publications

Inhalable microparticles as drug delivery systems to the lungs in a dry powder formulations

Inhalable microparticles as drug delivery systems to the lungs in a dry powder formulations

Preparation and Characterization of Ibuprofen Containing Nano-Embedded-Microparticles for Pulmonary Delivery

Investigation of Physico-Chemical Stability and Aerodynamic Properties of Novel “Nano-in-Micro” Structured Dry Powder Inhaler System

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