2022
DOI: 10.1371/journal.pone.0268067
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Nano-hydroxyapatite improves intestinal absorption of acetazolamide (BCS Class IV drug)–but how?

Abstract: We earlier reported that coating poorly water-soluble drugs with nano-hydroxyapatite (nano-HAP) improves bioavailability after oral administration. In the present study, we coated BCS Class IV drug acetazolamide (AZ) with nano-HAP (AZ/HAP formulation), and investigated its bioavailability and nano-HAP’s role in promoting it. We tested AZ bioavailability after a single oral dose of the AZ/HAP formulation in rats, followed by a series of in vitro, ex vivo and in vivo testing. The binding state of AZ and nano-HAP… Show more

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Cited by 3 publications
(2 citation statements)
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“…Group 3: (Arthritic + Nano-HAP/Vit B12): CFA-induced arthritic rats were given a safe oral dose of nano-HAP/Vit B12 at a daily dose of 30 mg/kg body weight [81] for 21 days.…”
Section: Induction Of Arthritis and Animal Groupingmentioning
confidence: 99%
See 1 more Smart Citation
“…Group 3: (Arthritic + Nano-HAP/Vit B12): CFA-induced arthritic rats were given a safe oral dose of nano-HAP/Vit B12 at a daily dose of 30 mg/kg body weight [81] for 21 days.…”
Section: Induction Of Arthritis and Animal Groupingmentioning
confidence: 99%
“…Group 2: (Arthritic positive control group): CFA-induced arthritic rats were treated for 21 days with equivalent amounts of vehicle (saline) taken orally every day. Group 3: (Arthritic + Nano-HAP/Vit B 12 ): CFA-induced arthritic rats were given a safe oral dose of nano-HAP/Vit B 12 at a daily dose of 30 mg/kg body weight [81] for 21 days.…”
Section: Collection Of Blood and Tissuementioning
confidence: 99%