Nano-hydroxyapatite (nHAp) scaffolds for bone regeneration: Preparation, characterization and biological applications

Damiri, Fouad; Fatimi, Ahmed; Magdalena Musuc, Adina; Paiva Santos, Ana Cláudia; Paszkiewicz, Sandra; Igwe Idumah, Chistopher; Singh, Sudarshan; Varma, Rajender S.; Berrada, Mohammed

doi:10.1016/j.jddst.2024.105601

Cited by 15 publications

(3 citation statements)

References 171 publications

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“…The difference in dimensions between the crystallite size and particle length arises because the crystallite size pertains to the internal atomic structure of HA, determined via XRD, whereas the particle length, observed through SEM, measures the physical dimensions of the entire HA particle, influenced by their aggregation and surface characteristics. All conditions in this experiment resulted in crystallite sizes of nHA of less than 100 nm, which is consistent with the nanoscale size of the nHA crystals found in human bone [5,39]. nHA has a large specific surface area, promoting cell proliferation and alkaline phosphatase synthesis and increasing the calcium ion concentration in the extracellular matrix [40].…”

Section: Characteristics Of Nha Prepared Under Various Hydrothermal R...supporting

confidence: 85%

“…Hydroxyapatite (HA) is well regarded for its bioactivity, cell adhesion, cell proliferation [2], and osteoconductivity [3], making it a prominent material in biomedical applications. Due to its ability to form bonds with bone tissue, HA is extensively utilized as a bone replacement and graft material [4,5]. Additionally, HA is employed in bioactive coatings [6,7], protein delivery media [8], drug carriers [9], and for the purification of nucleic acids during chromatographic analysis [10].…”

Section: Introductionmentioning

confidence: 99%

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Enhancing Bioactivity and Mechanical Properties of Nano-Hydroxyapatite Derived from Oyster Shells through Hydrothermal Synthesis

Wu,

Hsu,

et al. 2024

Nanomaterials

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Nano-hydroxyapatite (nHA) demonstrates favorable biological activity, cell adhesion, cell proliferation, and osteoconductivity, making it highly valuable in biomedicine. It is extensively used as a bone substitute and in bone transplantation within the dental and orthopedic fields. This study employed oyster shells as a calcium source to synthesize nHA at 150 °C with various hydrothermal reaction durations (10 min, 1 h, 6 h, and 12 h). As a control, HA synthesized via a wet precipitation method for 1 h at room temperature was utilized. Subsequent material analyses, including XRD, FE-SEM, FTIR, and ICP-MS, were conducted, followed by comprehensive evaluations of the bioactivity, cell attachment, cell proliferation, and sintering properties of the synthesized nHA. The results indicated that nHA synthesized through the hydrothermal reaction produced nanoscale crystals, with the aspect ratio of nHA particles increasing with the duration of hydrothermal treatment. Notably, rod-like nHA particles became prominent with hydrothermal durations exceeding 6 h. nHA particles derived from oyster shells contained carbonate and trace elements (Na, Mg, K, and Sr), similar to constituents found in human hard tissue such as bone and teeth. The immersion of nHA synthesized at 150 °C for 1 h (HT2) in simulated body fluid (SBF) for 28 d led to the formation of a bone-like apatite layer on the surface, indicating the excellent bioactivity of the synthesized nHA. The cell culture results revealed superior cell attachment and proliferation for nHA (HT2). Following the sequential formation and sintering at 1200 °C for 4 h, HT2 ceramics exhibited enhanced microhardness (5.65 GPa) and fracture toughness (1.23 MPa·m0.5), surpassing those of human tooth enamel.

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Section: Characteristics Of Nha Prepared Under Various Hydrothermal R...supporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Enhancing Bioactivity and Mechanical Properties of Nano-Hydroxyapatite Derived from Oyster Shells through Hydrothermal Synthesis

Wu,

Hsu,

et al. 2024

Nanomaterials

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“…Ap exhibits thermodynamic stability in body fluids when crystallized and shares a compositional likeness with bone minerals, facilitating its integration into bone structures without eliciting inflammatory responses or local or systemic toxicity [13]. This compatibility underscores its significant potential in different biomedical applications and for bone tissue engineering (BTE) in particular [14], [15].…”

Section: Summary Of Relevant Literaturementioning

confidence: 99%

Ceramic Hydroxyapatite Derived from Fish Scales in Biomedical Applications: a Systematic Review

Ibrahim,

Abdelmonem,

Ismail

et al. 2024

Precision Nanomedicine

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<img src=” https://s3.amazonaws.com/production.scholastica/article/120415/medium/prnano_1362024ga.jpg?1719353187”> The production of fish waste is increasing dramatically, as more than 70% of captured fish require processing before being sold. These enormous amounts of fish by-products are mostly wasted, generating an undesirable environmental impact and a loss of value-added products. Recently, there has been a growing interest in utilizing fish scale waste as a low-cost source to produce natural nano-hydroxyapatite (HAp) ceramic growth and sustainability. On 1 April 2023, an electronic search was performed across four major databases (ScienceDirect, ProQuest, Scopus, and PubMed). Among the 1824 articles identified, only 27 met this review’s inclusion criteria. These studies not only extracted HAp from fish scales but conducted in vitro or in vivo assessments. The in vitro studies demonstrated the non-cytotoxic nature of the fish-scale derived HAp and its superior cell viability compared to control or synthetic HAp. Furthermore, histopathological evaluations revealed favorable bioavailability and biological responses. These findings indicate that HAp obtained from natural sources offers an environmentally friendly, sustainable, and cost-effective approach for manufacturing these materials and is fully utilized for commercial purposes. Such materials are promising for biomedical applications, contributing positively to the economy, environment, and overall community well-being.

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Biogenic metallic nanoparticles: from green synthesis to clinical translation

Shah,

Chorawala,

Mansuri

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Nano-hydroxyapatite (nHAp) scaffolds for bone regeneration: Preparation, characterization and biological applications

Cited by 15 publications

References 171 publications

Enhancing Bioactivity and Mechanical Properties of Nano-Hydroxyapatite Derived from Oyster Shells through Hydrothermal Synthesis

Enhancing Bioactivity and Mechanical Properties of Nano-Hydroxyapatite Derived from Oyster Shells through Hydrothermal Synthesis

Ceramic Hydroxyapatite Derived from Fish Scales in Biomedical Applications: a Systematic Review

Biogenic metallic nanoparticles: from green synthesis to clinical translation

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