Nano-hydroxyapatite polymeric hydrogels for dye removal

Varaprasad, Kokkarachedu; Nunez, Dariela; Yallapu, Murali M.; Jayaramudu, Tippabattini; Elgueta, Elizabeth; Oyarzún, Patricio

doi:10.1039/c8ra01887a

Cited by 32 publications

(9 citation statements)

References 42 publications

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“…The small band at 1454 cm –1 may be attributed to the carboxylate group coordinated to the HA surface under different configurations . A sharp peak was observed at 1028 cm –1 , which may be credited to the asymmetric stretching of phosphate ions (PO 4 3– ) . The mixture of HA nanopowder, gelatin, and acrylic acid shows major peaks of HA nanopowder, gelatin, and acrylic acid.…”

Section: Resultsmentioning

confidence: 95%

Nanohydroxyapatite-, Gelatin-, and Acrylic Acid-Based Novel Dental Restorative Material

Sharma

Thapa³

et al. 2020

ACS Omega

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The aim of this study was to prepare a novel dental restorative material (NDRM) and to understand its cell viability behavior. The hydroxyapatite (HA) nanopowder was synthesized using a wet chemical precipitation method using calcium hydroxide and orthophosphoric acid as precursors. The as-prepared HA nanopowder was annealed at different temperatures to get a pure compound with a Ca/P ratio close to 1.67. The optimal temperature was found to be 600 °C, whereas at a higher temperature, HA starts decomposing into CaO. The preparation of NDRM was conducted in two steps. The first step comprises the preparation of HA nanopowder-and gelatin (G)-based film using microwave heating. In the second step, the homogenized mixture of the HA-G film was mixed with different amounts of acrylic acid to form a self-flowable NDRM paste. Further, both these materials (HA nanopowder and NDRM) were characterized using FTIR, XRD, and SEM−EDX analyses. The FTIR and XRD results show the peaks corresponding to natural bone apatite and therefore confirm the formation of HA. EDX results showed the presence of Ca and P in HA nanopowder and NDRM with Ca/P ratios of 1.79 and 1.63, respectively. Synthesized NDRM was also analyzed for its in vitro cytotoxic and reproductive viability potential against normal cells using MTT and clonogenic assay. The analysis showed significantly higher cellular viability on the treatment with NDRM when compared to HA nanopowder as well as no colony suppression by both materials was observed on the normal cell line (fR2) even after exposure for 24 h, indicating its nontoxicity. The synthesized NDRM therefore can be considered as a promising candidate for dental caries restoration applications.

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Section: Resultsmentioning

confidence: 95%

Nanohydroxyapatite-, Gelatin-, and Acrylic Acid-Based Novel Dental Restorative Material

Sharma

Thapa³

et al. 2020

ACS Omega

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“…Toxic dye removal from waste water is of great concern for environmental reasons during the last few decades. − Adsorption of fluorophores in the self-assemblies as observed by epifluorescence microscopy inspired us to investigate whether the porous self-assemblies of the flower and fibrillar network could be capable of removing the toxic dyes like rhodamine-B, methylene blue (MB), crystal violet (CV), and rhodamine-6G from their respective aqueous solution. For these studies, aqueous solutions of dyes were prepared by dissolving a weighed amount of dye in distilled water.…”

Section: Results and Discussionmentioning

confidence: 99%

Flower- and Grass-like Self-Assemblies of an Oleanane-Type Triterpenoid Erythrodiol: Application in the Removal of Toxic Dye from Water

Panja

Bag

2020

ACS Omega

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(C 30 H 50 O 2 ) 1 is a nanosized oleanane-type fused 6-6-6-6-6 pentacyclic triterpeneoid extractable from the dried leaves of olive (Olea europia). One step reduction of oleanolic acid extracted from Lantana camara also yields the same compound. The triterpenoid has one secondary −OH group attached at C3 of the "A" ring and one primary −OH group at C28 present at the junction of the "D" and "E" rings. Here, we report the spontaneous self-assembly of erythrodiol in different neat organic liquids and aqueous-organic liquid mixtures. The nanosized dihydroxy triterpenoid having an oleanane-type lipophilic rigid skeleton self-assembled in liquids, yielding nanosized fibrils, microsized flowers, and grass-like architectures via formation of densely assembled fibrils and petals or 2D sheets. The microstructures of the self-assemblies have been characterized by different techniques like optical microscopy, electron microscopy, atomic force microscopy, FTIR, and wide angle X-ray diffraction studies. The porous self-assemblies having a large surface area obtained from 1 were capable of adsorbing toxic fluorophores like rhodamine-B, rhodamine-6G, methylene blue, and crystal violet (CV). Moreover, removal of the aforementioned toxic pigments has also been demonstrated from their aqueous solutions by using UV−visible spectrophotometry and epifluorescence microscopy.

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“…The absorptive capacity of dressings was determined using gravimetric method. 30 The test dressings immersed in phosphate buffer (PBS) for 30 min at 37 °C. The water absorption capacity was calculated as follows: …”

Section: Methodsmentioning

confidence: 99%

Preparation of biocompatible wound dressings with dual release of antibiotic and platelet-rich plasma for enhancing infected wound healing

et al. 2021

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The ever-growing threats of bacterial infection and chronic wound healing have provoked an urgent need for novel antibacterial wound dressings. In this study, we developed a wound dressing for the treatment of infected wounds, which can reduce the inflammatory period (through the use of gentamycin sulfate (GS)) and enhance the granulation stage (through the addition of platelet-rich plasma (PRP)). Herein, the sustained antimicrobial CMC/GMs@GS/PRP wound dressings were developed by using gelatin microspheres (GMs) loading GS and PRP, covalent bonding to carboxymethyl chitosan (CMC). The prepared dressings exhibited high water uptake capability, appropriate porosity, excellent mechanical properties, sustain release of PRP and GS. Meanwhile, the wound dressing showed good biocompatibility and excellent antibacterial ability against Gram-negative and Gram-positive bacteria. Moreover, in vivo experiments further demonstrated that the prepared dressings could accelerate the healing process of E. coli and S. aureus-infected full-thickness wounds i n vivo, reepithelialization, collagen deposition and angiogenesis. In addition, the treatment of CMC/GMs@GS/PRP wound dressing could reduce bacterial count, inhibit pro-inflammatory factors (TNF-α, IL-1β and IL-6), and enhance anti-inflammatory factors (TGF-β1). The findings of this study suggested that biocompatible wound dressings with dual release of GS and PRP have great potential in the treatment of chronic and infected wounds.

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Nano-hydroxyapatite polymeric hydrogels for dye removal

Abstract: Schematic diagram of nHA and nHA based hydrogels development via wet chemical and free-radical polymerization process and absorbent process of nHA hydrogel.

Cited by 32 publications

References 42 publications

Nanohydroxyapatite-, Gelatin-, and Acrylic Acid-Based Novel Dental Restorative Material

Nanohydroxyapatite-, Gelatin-, and Acrylic Acid-Based Novel Dental Restorative Material

Flower- and Grass-like Self-Assemblies of an Oleanane-Type Triterpenoid Erythrodiol: Application in the Removal of Toxic Dye from Water

Preparation of biocompatible wound dressings with dual release of antibiotic and platelet-rich plasma for enhancing infected wound healing

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