Nano hydroxyapatite toothpaste as a treatment for dentine hypersensitivity

Abstract

Introduction: Dentin hypersensitivity (DH) is a common and painful clinical occurrence that can negatively impact patients' quality of life. An arsenal of different desensitizing molecules is available on the market, but no gold standard has yet to be set. Aim: The aim of this study was to perform a review on the potential of nano-hydroxyapatite (n-HA) as a desensitizing toothpaste agent as opposed to placebo or other desensitizing molecules. Materials and Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, an electronic search of the PubMed database was conducted from inception up until May 2021. Seven English written randomized controlled trials about the use of n-HA toothpaste in treating adults with DH were assessed for quality via the modified Jadad scale, and included in the review. Non-English studies, publications involving lasers, and studies researching the effect of n-HA on gingival inflammation or postwhitening sensitivity were all excluded. Results and Discussion: Available evidence suggests that n-HA is a promising addition to the growing arsenal of desensitizing treatments available on the market. Conclusion: n-HA remains a viable everyday option that dentists should strongly consider for their patients' pain relief. However, due to the heterogeneity of pain studies and the lack of standardization in trial protocols, no evidence of superiority to other desensitizing agents can be ascertained, thus far.

Nanotechnology in toothpaste: Fundamentals, trends, and safety

“…F has been considered the most effective caries-inhibiting agent for several decades; however, due to some side effect issues in children and lower public acceptance, another effective alternative is required [ 35 ]. Therefore, some researchers introduced HAP in toothpaste as a substitute for The F. In addition, HAP also acts as a source of calcium and phosphate ions, has a whitening effect, and reduces dental hypersensitization [ 36 , 37 ].…”

Nanohydroxyapatite in dentistry: A comprehensive review

“…In a comparative study showed that 2.5% Arginine and nHA are equally effective for the management of post-bleaching dentin sensitivity ( Moharam et al, 2022 ). Studies report that there is enhanced clinical performance and dentine hypersensitivity relief using nHA containing agents ( de Melo Alencar et al, 2019 , Oubenyahya, 2021 ). Clinically toothpaste containing either 10% or 15% nHA (10 or 15%) solely or supplemented with potassium nitrate was as effective as calcium sodium phosphosilicate for relief of dentine hypersensitivity symptoms when applied at least twice daily.…”

Clinical Evidence of Biomimetic Hydroxyapatite in Oral Care Products for Reducing Dentin Hypersensitivity: An Updated Systematic Review and Meta-Analysis

“…There are several agents that have been investigated in the past to conservatively treat DH [ 7 , 8 ]. There have been 8 systematic reviews of therapeutic treatment of dentin hypersensitivity published in the recent past that included studies on hydroxyapatite (HAP) as an active desensitization agent [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ] ( Supplementary Materials : Table S1 ). They included studies on HAP that ranged in number from just one to as many as 20 studies.…”