Nano-Modified Titanium Implant Materials: A Way Toward Improved Antibacterial Properties

Liu, Jianqiao; Liu, Jia; Attarilar, Shokouh; Wang, Chong; Tamaddon, Maryam; Yang, Chengliang; Xie, Kegong; Yao, Jin-Guang; Wang, Liqiang; Liu, Chaozong; Tang, Yue

doi:10.3389/fbioe.2020.576969

Cited by 91 publications

(64 citation statements)

References 396 publications

(348 reference statements)

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“…Compared with nanoparticles of other metals such as Ag, Cu, and Zn, Au nanoparticles have higher biological safety and relatively weak antibacterial ability. Possible mechanisms include direct contact with the outer membrane of bacteria causing membrane disruption, the production of ROS, photothermal effects, and photocatalysis (Liu et al, 2020). Among them, the membrane damage caused by direct contact plays a major role (Liu et al, 2020).…”

Section: Aumentioning

confidence: 99%

“…Possible mechanisms include direct contact with the outer membrane of bacteria causing membrane disruption, the production of ROS, photothermal effects, and photocatalysis (Liu et al, 2020). Among them, the membrane damage caused by direct contact plays a major role (Liu et al, 2020). Au is mainly used as a coating in tooth restoration, and there is no report on the application of Au alloys in orthopedics.…”

Section: Aumentioning

confidence: 99%

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Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Jiao

Zhang

et al. 2021

Front. Cell. Infect. Microbiol.

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Implants are widely used in orthopedic surgery and are gaining attention of late. However, their use is restricted by implant-associated infections (IAI), which represent one of the most serious and dangerous complications of implant surgeries. Various strategies have been developed to prevent and treat IAI, among which the closest to clinical translation is designing metal materials with antibacterial functions by alloying methods based on existing materials, including titanium, cobalt, tantalum, and biodegradable metals. This review first discusses the complex interaction between bacteria, host cells, and materials in IAI and the mechanisms underlying the antibacterial effects of biomedical metals and alloys. Then, their applications for the prevention and treatment of IAI are highlighted. Finally, new insights into their clinical translation are provided. This review also provides suggestions for further development of antibacterial metals and alloys.

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Section: Aumentioning

confidence: 99%

Section: Aumentioning

confidence: 99%

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Jiao

Zhang

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Among them, the localized release of antibiotics, organic or inorganic antibacterial agents, such as metal ions or nanoparticles, can be cited [9][10][11][12]. Finally, topographical modifications should be synergistically designed to be suitable for both the optimization of tissue integration and infection passive prevention, such as through surface nanotextures [13][14][15][16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Contact Guidance Effect and Prevention of Microfouling on a Beta Titanium Alloy Surface Structured by Electron-Beam Technology

et al. 2021

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Nano- and micro-structuring of implantable materials constitute a promising approach to introduce mechanical contact guidance effect, drive cells colonization, as well as to prevent bacteria adhesion and biofilm aggregation, through antifouling topography. Accordingly, this paper aims to extend the application of e-beam surface texturing and nano-structuring to the beta titanium alloys, which are of great interest for biomedical implants because of the low Young modulus and the reduction of the stress shielding effect. The paper shows that surface texturing on the micro-scale (micro-grooves) is functional to a contact guidance effect on gingival fibroblasts. Moreover, nano-structuring, derived from the e-beam surface treatment, is effective to prevent microfouling. In fact, human fibroblasts were cultivated directly onto grooved specimens showing to sense the surface micro-structure thus spreading following the grooves’ orientation. Moreover, Staphylococcus aureus colonies adhesion was prevented by the nano-topographies in comparison to the mirror-polished control, thus demonstrating promising antifouling properties. Furthermore, the research goes into detail to understand the mechanism of microfouling prevention due to nano-topography and microstructure.

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“…Bacterial infection is one of the major concerns in tissue regeneration and wound healing, and inhibition of bacteria growth plays a key role in the wound healing process. [ 21 ] In addition to the application of antibiotics, different antibacterial approaches have been investigated including metal ions, [ 22 ] nanoeffect, [ 23 ] nitric oxide, [ 24 ] photocatalysis [ 25 ] and photothermal treatment. [ 21a ] Previous studied have shown that both photothermal and photocatalytic effect are able to inhibit bacteria growth.…”

Section: Discussionmentioning

confidence: 99%

Multi‐Functional Black Bioactive Glasses Prepared via Containerless Melting Process for Tumor Therapy and Tissue Regeneration

Wang

et al. 2021

Adv Funct Materials

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Tissue regeneration in complex lesions such as the site of tumors, bacterial infection, and sites lacking blood vessels, has been a huge challenge. Therefore, developing bioactive implantable materials with multi‐functional properties such as tumor destruction, bacteria growth inhibition, and angiogenesis promotion is of great significance. In this study, black CaO‐SiO2‐TiO2 (CST) glasses are prepared through the containerless melting approach, by which heterogeneous nucleation can be avoided and thereby glass formation becomes possible via fast quenching. This approach enables the formation of trivalent titanium (Ti3+) without using a reducing atmosphere or reducing agents. The black CST glasses are found in this study to possess a strong ability to inhibit bacteria and tumors by their excellent photothermal and photocatalytic effects. Strikingly, these glasses also promote the formation of blood vessels and accelerate the healing of chronic wounds by the synergistic effects of the photothermal effect and Si ions. Thus, this glass system can be a promising multi‐functional material for tissue regeneration in complex lesions.

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Nano-Modified Titanium Implant Materials: A Way Toward Improved Antibacterial Properties

Abstract: Graphical Abstract

Cited by 91 publications

References 396 publications

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Contact Guidance Effect and Prevention of Microfouling on a Beta Titanium Alloy Surface Structured by Electron-Beam Technology

Multi‐Functional Black Bioactive Glasses Prepared via Containerless Melting Process for Tumor Therapy and Tissue Regeneration

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