Nano Propolis, Zinc Oxide Nanoparticles, and Their Composites: A Novel Green Synthesis with Synergistic Antioxidant and Anticancer Properties

Salama, Shaimaa A.; Atta, Ramadan R.; Khalil, Ensaf M.; Abdelaleim, Yasser F.; Abd-Eltawab, Samah; Farghali, Ahmed A.; Essam, Doaa; Alkhalifah, Dalal Hussien M.; Hozzein, Wael N.; Mahmoud, Rehab

doi:10.3390/jcs7110480

Cited by 3 publications

(2 citation statements)

References 80 publications

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“…The composite of ZnO and propolis (ZnO-P NCs) exhibited strong cytotoxic effects on breast cancer cells, displaying an IC50 value of 18 µg/mL, indicating its potential for the treatment of breast cancer [106] Cervical ZnO-P NCs shows cytotoxicity against cervical cancer with an IC50 value of 23 µg/mL Liver Ethanol…”

Section: Indonesia Propolis Breast Ethanolmentioning

confidence: 99%

“…Zinc Oxide-Propolis NanocompositePropolis nanoparticle prepared by ball mill method and Zinc oxide nanoparticle obtained by coprecipitated using zinc nitrate and propolis aqueous extract. Then, ZnO-Propolis Nanocomposite synthesize by green synthesis approach by mixing both propolis and ZnO nanoparticle and centrifuged in 4 times zinc nitrate, milli-Q water, propolis 9.70[106] …”

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confidence: 99%

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New insights of propolis nanoformulation and its therapeutic potential in human diseases

Kustiawan,

Syaifie,

Siregar

et al. 2024

ADMET DMPK

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Background and purpose: Scientific research is crucial to develop therapies for various disease severity levels, as modern drugs cause side effects and are difficult to predict. Researchers are exploring herbal alternatives with fewer side effects, particularly propolis, which has been validated through in vitro, in vivo, and clinical studies. This will focus on scientific evidence and its supporting technology for developing new bioactive compounds for chronic diseases. Nanotechnology can improve the delivery and absorption of herbal medicines, which often have poor bioavailability due to their high molecular weight and solubility in water, particularly in oral medicines. This technology can enhance propolis's effects through multi-target therapy and reduce side effects. Experimental approach: All publications related to each section of this review were discovered using the search engines Google Scholar, Scopus, and Pubmed. This was only available for publication between 2013 and 2023. The selected publications were used as references in this review after being thoroughly studied. Key results: Evaluation of propolis active compounds, the classification of propolis nano formulations, design concepts, and mechanisms of action of propolis nano formulation. Additionally, the challenges and prospects for how these insights can be translated into clinical benefits are discussed. Conclusion: In the last ten years, a list of nanoformulation propolis has been reported. This review concludes the difficulties encountered in developing large-scale nanoformulations. To commercialize them, improvements in nano carrier synthesis, standardized evaluation methodology within the framework of strategy process improvement, and Good Manufacturing Practices would be required.

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Section: Indonesia Propolis Breast Ethanolmentioning

confidence: 99%

mentioning

confidence: 99%

New insights of propolis nanoformulation and its therapeutic potential in human diseases

Kustiawan,

Syaifie,

Siregar

et al. 2024

ADMET DMPK

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Green synthesis of silver and gold-doped zinc oxide nanocomposite with propolis extract for enhanced anticancer activity

Abdelsattar,

Yakoup,

Kamel

et al. 2024

Sci Rep

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Metal and metal oxide nanocomposites have unique properties and are promising for antibacterial and anticancer applications. In this work, we aimed to highlight the relationship between the biosynthesis ways of silver and gold-doped zinc oxide nanocomposites and their functions as anticancer on cell lines (MCF-7 and HepG2). The propolis was used to biosynthesize four different nanoparticles with the same components, including zinc, gold and silver. The nanocomposites were characterized using various techniques, including ultraviolet–visible spectroscopy (UV–Vis), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Energy Dispersive X-ray analysis (EDX) and cytotoxicity assays. The result of this study showed that formed nanocomposites have a similar level of Zn, Au, and Ag, ranging from 23–34%, 2–6%, and 2–3%, respectively. In addition, adding the components simultaneously produces the fastest color change, and the fabricated nanoparticles have spherical shapes with different layers. In addition, the prepared nanoparticles influenced the cell viability of the cancer cell lines, with the most effective one when Zn, Au, and Ag were added spontaneously to form a nanocomposite called (All) with IC50 of 24.5 µg/mL for MCF7 cells and 29.1 µg/mL for HepG2 cells. Thus, the study illustrates that the preparation of nanocomposite generated through green synthesis with different methods significantly affects the structure and function and may improve the synthesis of nanocomposite to be developed into an efficacious therapeutic agent for cancers. In addition, this study opens the door toward a novel track in the field of nanocomposites as it links the synthesis with structure and function. Further anti-cancer properties, as well as animal testing are needed for those nanocomposites.

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Chemical Synthesis and Characterization of Fatty Acid-Capped ZnO Nanoparticles

Matei,

Stoian,

Crăciun

et al. 2024

J. Compos. Sci.

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In the current study, ZnO nanoparticles were obtained using a chemical process employing zinc acetate as the precursor, followed by thermal processing in air. To prevent agglomeration and increase the stability of ZnO nanoparticles, two unsaturated acids (e.g., elaidic acid and linoleic acid) and two saturated acids (e.g., stearic acid and lauric acid) were selected as capping agents. ZnO nanoparticles were investigated before and after surface modification with different fatty acids. Structural and morphological analyses of the samples were performed using FTIR and RAMAN spectroscopy, X-ray diffraction, SEM microscopy, and wetting capacity. Characterization studies revealed that the synthesized ZnO nanoparticles present well-defined crystalline structures, with crystallite sizes varying between 26 and 28 nm, and the average particle size was in the range of 10–55 nm (depending on the type of fatty acids used). The goniometric analysis followed the wetting capacity of the sample surface. The study results reveal that the capping agents have a considerable impact on the surface modification of the nanoparticles by increasing the contact angle. By producing nanoparticles with hydrophobic behavior, there is the possibility of opening up future research for their use in various applications across many industrial fields.

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Nano Propolis, Zinc Oxide Nanoparticles, and Their Composites: A Novel Green Synthesis with Synergistic Antioxidant and Anticancer Properties

Cited by 3 publications

References 80 publications

New insights of propolis nanoformulation and its therapeutic potential in human diseases

New insights of propolis nanoformulation and its therapeutic potential in human diseases

Green synthesis of silver and gold-doped zinc oxide nanocomposite with propolis extract for enhanced anticancer activity

Chemical Synthesis and Characterization of Fatty Acid-Capped ZnO Nanoparticles

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