Nano Silver-Induced Toxicity and Associated Mechanisms

Zhang, Jing; Wang, Fang; Yalamarty, Satya Siva Kishan; Filipczak, Nina; Jin, Y.; Li, Xiang

doi:10.2147/ijn.s355131

Cited by 68 publications

(26 citation statements)

References 92 publications

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“…The different effects exerted by AgNO 3 and AgNPs suggested that silver in the form of nanoparticles might solely enter the mitochondria or nucleus and induce the expression of TFAM and PGC-1α, leading to protective effects on myocardial cells. It is of interest that many published articles stated that exposure of cells to AgNPs can cause mitochondrial damage such as mitochondrial swelling, disrupting mitochondrial membrane potentials and leading to mitochondrial pathway-induced apoptosis ( 53 ) but we found the opposite effects in our study. We speculate that the green synthesized method of our AgNPs formulation by using alginate may contribute to its beneficial effects ( 54 ).…”

Section: Discussioncontrasting

confidence: 61%

Protective effects of silver nanoparticles in isoproterenol-induced myocardial infarction in rats

et al. 2022

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BackgroundSilver nanoparticles (AgNPs) are widely used in the medical field, including cardiovascular. However, limited research has investigated the effect of AgNPs on the protection of myocardial infarction (MI).ObjectivesIsoproterenol (Iso)-induced MI and the cardiac protection offered by AgNPs were investigated in the present study. Additionally, we characterized the profile of Ag in the form of nanoparticles.MethodsTwenty-four male Wistar rats were randomly divided into four groups as follows: normal, Iso, Iso + AgNO3, and Iso + AgNP groups. AgNPs and silver ion (AgNO3) were administered intraperitoneally at 2.5 mg/kg BW for 14 days. Iso induction was performed using two doses of 85 mg/kg BW given subcutaneously on days 13 and 14. Blood and cardiac tissue samples were taken 24 h after the last dose of Iso and checked for Creatine Kinase-MB (CK-MB), lactate dehydrogenase in plasma along with oxidative stress parameters, mitochondria biogenesis markers, and inflammation representative genes in cardiac tissue. Additionally, we analyzed the histopathological features in cardiac tissue.ResultsThe silver was confirmed in the form of nanoparticles by its size at intervals of 8.72–37.84 nm. Both AgNO3 and AgNPs showed similar cardioprotective effects, as shown by the decrease in biochemical markers of cardiac toxicity, namely, CK-MB. Additionally, AgNPs group have better efficacy compared with AgNO3 group in ameliorating Iso-mediated oxidative stress production, as evidenced by the significant decrease in malondialdehyde level and increased superoxide dismutase activity (P < 0.0001 and P < 0.01, respectively) in cardiac tissue compared with the Iso group. Mechanistically, AgNPs, but not AgNO3, enhanced the expression levels of mitochondrial transcription factor A and peroxisome proliferator-activated receptor-gamma coactivator 1-alpha in post-MI heart and reduced the protein expression of nuclear factor-kappa B (NF-κB) assessed by western blot analysis. Furthermore, these results were confirmed with the histopathological evaluation of cardiac tissue. Nevertheless, pretreatment with either AgNO3 or AgNPs improved the aspartate aminotransferase level.ConclusionThese results suggested that AgNPs have more superior cardioprotective effect compared with AgNO3 against Iso-induced MI, at least in part through amelioration of NF-κB expression level induced by oxidative stress overproduction.

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Section: Discussioncontrasting

confidence: 61%

Protective effects of silver nanoparticles in isoproterenol-induced myocardial infarction in rats

et al. 2022

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“…Various bone-filling materials containing antimicrobial components were also proposed in the literature, with the purpose being to prevent perioperative infections. Silver nanoparticles are one of the choices [ 19 ]; however, their long-term safety is still a matter of debate [ 20 ]. Chitosan [ 4 ] and its quaternized derivative [ 21 ] were also reported to exhibit antibacterial properties and thus may serve as a bioactive component of the scaffold.…”

Section: Introductionmentioning

confidence: 99%

Clindamycin-Loaded Halloysite Nanotubes as the Antibacterial Component of Composite Hydrogel for Bone Repair

et al. 2022

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A new drug delivery system consisting of clindamycin phosphate entrapped in acid-etched halloysite nanotubes was successfully prepared and characterized. It was then used as an antibacterial component of the multicomponent hydrogel designed as a material for bone regeneration. First, halloysite (HNT) was etched and clindamycin phosphate (CP) was entrapped in both raw and modified nanotubes, resulting in HNT-CP and EHNT-CP systems. They were characterized using SEM, TEM, TGA and FTIR; the entrapment efficiency and release of CP from both systems were also studied. EHNT-CP was then used as an antibacterial component of the two hydrogels composed of alginate, collagen and β-TCP. The hydrogels were prepared using different crosslinking procedures but had the same composition. The morphology, porosity, degradation rate, CP release profile, cytocompatibility, antibacterial activity and ability to induce biomineralization were studied for both materials. The hydrogel obtained by a chemical crosslinking with EDC followed by the physical crosslinking with calcium ions had better properties and was shown to have potential as a bone repair material.

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“…The biocompatibility of implants is a crucial criterion for their biomedical application. In the case of silver-containing implants, the release of Ag may cause cytotoxicity, which is attributed to the generation of ROS, destabilization of the cell membrane, and inactivation of essential enzymes. , The cell viability of pure PICN and Ag@PL NPs/PICN samples was assessed in vitro employing two different cell models, HaCaT and BJ5ta, which are immortalized cell lines from adult human skin with keratinocyte and fibroblast-like morphology, respectively. The culture media previously pre-incubated with Ag@PL NPs/PICN and PICN samples for 24 h or 7 days were used to grow the cells for 24 h, while a fresh medium that has not been in contact with the samples was used to grow control cells.…”

Section: Resultsmentioning

confidence: 99%

3D-Printed Polymer-Infiltrated Ceramic Network with Antibacterial Biobased Silver Nanoparticles

Hodásová

Morena

Tzanov

et al. 2022

ACS Appl. Bio Mater.

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This work aimed at the antimicrobial functionalization of 3D-printed polymer-infiltrated biomimetic ceramic networks (PICN). The antimicrobial properties of the polymer-ceramic composites were achieved by coating them with human- and environmentally safe silver nanoparticles trapped in a phenolated lignin matrix (Ag@PL NPs). Lignin was enzymatically phenolated and used as a biobased reducing agent to obtain stable Ag@PL NPs, which were then formulated in a silane (γ-MPS) solution and deposited to the PICN surface. The presence of the NPs and their proper attachment to the surface were analyzed with spectroscopic methods (FTIR and Raman) and X-ray photoelectron spectroscopy (XPS). Homogeneous distribution of 13.4 ± 3.2 nm NPs was observed in the transmission electron microscopy (TEM) images. The functionalized samples were tested against Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria, validating their antimicrobial efficiency in 24 h. The bacterial reduction of S. aureus was 90% in comparison with the pristine surface of PICN. To confirm that the Ag-functionalized PICN scaffold is a safe material to be used in the biomedical field, its biocompatibility was demonstrated with human fibroblast (BJ-5ta) and keratinocyte (HaCaT) cells, which was higher than 80% in both cell lines.

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Nano Silver-Induced Toxicity and Associated Mechanisms

Cited by 68 publications

References 92 publications

Protective effects of silver nanoparticles in isoproterenol-induced myocardial infarction in rats

Protective effects of silver nanoparticles in isoproterenol-induced myocardial infarction in rats

Clindamycin-Loaded Halloysite Nanotubes as the Antibacterial Component of Composite Hydrogel for Bone Repair

3D-Printed Polymer-Infiltrated Ceramic Network with Antibacterial Biobased Silver Nanoparticles

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