Nano-Sized MIL-100(Fe) as a Carrier Material for Nitidine Chloride Reduces Toxicity and Enhances Anticancer Effects In Vitro

Bi, JiaRui; Zheng, Yu; Fang, Liqing; Guan, Yucheng; Ma, Aiqing; Wu, Jian

doi:10.1007/s10904-020-01548-z

Cited by 11 publications

(3 citation statements)

References 29 publications

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“…This NDDS notably enhanced solubility in aqueous environments and achieved a high drug-loading capacity of up to 33.43 wt%, significantly improving nitidine chloride's bioavailability. Furthermore, the release profile of nitidine chloride demonstrated a controlled, progressive drug release, with 68% of the drug being released within 4 days, indicating high stability in a biological medium (Bi et al, 2020). Furthermore, Li et al engineered folic acid-modified D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS-FA) nanocarriers for the controlled delivery of nitidine chloride.…”

Section: Other Alkaloid Compoundsmentioning

confidence: 99%

The development of nanocarriers for natural products

Huang,

Luo,

Tong

et al. 2024

WIREs Nanomed Nanobiotechnol

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Natural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant bioactive compounds is hindered by low solubility and instability. Conventional pharmaceutical forms, such as tablets and capsules, only partially overcome these limitations, restricting their efficacy. With the recent development of nanotechnology, nanocarriers can enhance the bioavailability, stability, and precise intracellular transport of plant bioactive compounds. Researchers are increasingly integrating nanocarrier‐based drug delivery systems (NDDS) into the development of natural plant compounds with significant success. Moreover, natural products benefit from nanotechnological enhancement and contribute to the innovation and optimization of nanocarriers via self‐assembly, grafting modifications, and biomimetic designs. This review aims to elucidate the collaborative and reciprocal advancement achieved by integrating nanocarriers with botanical products, such as bioactive compounds, polysaccharides, proteins, and extracellular vesicles. This review underscores the salient challenges in nanomedicine, encompassing long‐term safety evaluations of nanomedicine formulations, precise targeting mechanisms, biodistribution complexities, and hurdles in clinical translation. Further, this study provides new perspectives to leverage nanotechnology in promoting the development and optimization of natural plant products for nanomedical applications and guiding the progression of NDDS toward enhanced efficiency, precision, and safety.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Section: Other Alkaloid Compoundsmentioning

confidence: 99%

The development of nanocarriers for natural products

Huang,

Luo,

Tong

et al. 2024

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

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“…Whereas, its clinic practice is restricted due to the aspecific toxicity and poor bioavailability. In the research of Bi et al (2020) , they prepared nanoscale metal-organic frameworks MIL-100(Fe), which was adopted as a nanocarrier to deliver nitidine chloride. The results showed that MIL-100(Fe) had a high drug capacity (33.43 wt%) for nitidine chloride by the impregnation method.…”

Section: Formulation Of Nitidine Chloridementioning

confidence: 99%

Nitidine chloride, a benzophenanthridine alkaloid from Zanthoxylum nitidum (Roxb.) DC., exerts multiple beneficial properties, especially in tumors and inflammation-related diseases

Lü

Luo

et al. 2022

Front. Pharmacol.

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Plant-derived alkaloids are a kind of very important natural organic compounds. Nitidine chloride is one of the main active ingredients in Zanthoxylum nitidum (Roxb.) DC. which is a frequently-used Chinese herbal medicine. Z. nitidum has many kinds of efficacy, such as activating blood circulation and removing stasis, promoting qi circulation and relieving pain, and detoxication and detumescence. In China, Z. nitidum is usually used for the treatment of gastrointestinal diseases, toothache, and traumatic injury. At present, there are numerous studies of nitidine chloride with regard to its pharmacology, pharmacokinetics, toxicology, etc. However, a systematic, cutting-edge review of nitidine-related studies is extremely lacking. The present paper aimed at comprehensively summarizing the information on the extraction, separation and purification, pharmacology, pharmacokinetics, toxicology and formulation of nitidine chloride. The knowledge included in the present study were searched from the following academic databases involving Web of Science, PubMed, Google scholar, Elsevier, CNKI and Wanfang Data, till July 2022. In terms of nitidine chloride extraction, enzymatic method and ultrasonic method are recommended. Resin adsorption and chromatography were usually used for the separation and purification of nitidine chloride. Nitidine chloride possesses diversified therapeutical effects, such as anti-tumor, anti-inflammation, anti-colitis, anti-malaria, anti-osteoporosis, anti-rheumatoid and so on. According to pharmacokinetics, the intestinal absorption of nitidine chloride is passive diffusion, and it is rarely excreted with urine and feces in the form of prototype drug. Nitidine chloride has a moderate binding to plasma protein, which is independent of the drug concentration. As to toxicology, nitidine chloride showed certain toxicity on liver, kidney and heart. Certain new formulations, such as nanoparticle, microsphere and nano-micelle, could increase the therapeutic effect and decrease the toxicity of nitidine chloride. Despite limitations such as poor solubility, low bioavailability and certain toxicity, nitidine chloride is still a promising natural alkaloid for drug candidates. Extensive and intensive exploration on nitidine chloride is essential to promote the usage of nitidine-based drugs in the clinic practice.

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“…The existence of nitidine and other benzophenanthridine alkaloids as quaternary salts is a major problem in their study for cancer chemotherapy and other diseases, especially in vivo studies, because of their poor absorption and hence bioavailability. In attempts to find possible drug delivery systems to enhance their cancer chemotherapeutic profiles, the pharmacodynamics of nitidine chloride on various types of nanoparticles have been studied and found to reduce toxicity and enhance anticancer effects [ 120 ].…”

Section: Heterocyclic Compoundsmentioning

confidence: 99%

Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targets

et al. 2021

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Cancer is a complex group of diseases initiated by abnormal cell division with the potential of spreading to other parts of the body. The advancement in the discoveries of omics and bio- and cheminformatics has led to the identification of drugs inhibiting putative targets including vascular endothelial growth factor (VEGF) family receptors, fibroblast growth factors (FGF), platelet derived growth factors (PDGF), epidermal growth factor (EGF), thymidine phosphorylase (TP), and neuropeptide Y4 (NY4), amongst others. Drug resistance, systemic toxicity, and drug ineffectiveness for various cancer chemo-treatments are widespread. Due to this, efficient therapeutic agents targeting two or more of the putative targets in different cancer cells are proposed as cutting edge treatments. Heterocyclic compounds, both synthetic and natural products, have, however, contributed immensely to chemotherapeutics for treatments of various diseases, but little is known about such compounds and their multimodal anticancer properties. A compendium of heterocyclic synthetic and natural product multitarget anticancer compounds, their IC50, and biological targets of inhibition are therefore presented in this review.

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Nano-Sized MIL-100(Fe) as a Carrier Material for Nitidine Chloride Reduces Toxicity and Enhances Anticancer Effects In Vitro

Cited by 11 publications

References 29 publications

The development of nanocarriers for natural products

The development of nanocarriers for natural products

Nitidine chloride, a benzophenanthridine alkaloid from Zanthoxylum nitidum (Roxb.) DC., exerts multiple beneficial properties, especially in tumors and inflammation-related diseases

Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targets

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