Nano-structured nickel oxide based DNA biosensor for detection of visceral leishmaniasis (Kala-azar)

Mohan, Swati; Srivastava, Pankaj; Maheshwari, Sonam; Sundar, Shyam; Prakash, Rajiv

doi:10.1039/c1an15031f

Cited by 78 publications

(54 citation statements)

References 51 publications

(87 reference statements)

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“…anti-leishmanial therapy [14][15][16][17]. Although glucantime is commonly used for the treatment of leishmaniasis, it has some side effects including increased liver enzymes and electrocardiogram changes [17].…”

Section: Methodsmentioning

confidence: 99%

“…Although glucantime is commonly used for the treatment of leishmaniasis, it has some side effects including increased liver enzymes and electrocardiogram changes [17]. In addition, the drug is expensive, the injection is painful, and research shows that resistance of parasite to glucantime is growing in different parts of the world [17][18][19][20].…”

Section: Methodsmentioning

confidence: 99%

“…Artemisinin has been traditionally used for the treatment of malaria and has been reported to exhibit anti leishmanial and antitumor activities [2,[38][39][40]. Earlier, it has been proved that formulation of artemisinin-loaded nanoparticles improved its activity against L. donovani amastigotes ex vivo [17].…”

Section: Application Of Nano Drugs In Treatment Of Leishmaniasismentioning

confidence: 99%

“…This formulation may have a good safety profile, and if production costs are low, it may prove to be a feasible alternative to conventional amphotericin B in the treatment of VL [17,[25][26][27][28][29].…”

Section: Application Of Nano Drugs In Treatment Of Leishmaniasismentioning

confidence: 99%

“…If nanoparticles are systemically administered, they will be agglomerated after exposure to plasma, and their efficacy will be decreased [17]. Anti-leishmanial nanoparticles must be conjugated with biological compounds such as antibody or lectin, which bind to specific targets, in order to exert more toxicity for parasites and less toxicity for normal cells [21][22][23][24][25][26][27][28][29][30][31][32].…”

Section: Application Of Nano Drugs In Treatment Of Leishmaniasismentioning

confidence: 99%

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Application of Nano Drugs in Treatment of Leishmaniasis

Shahcheraghi¹

2016

Glob J Infect Dis Clin Res

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Objective: Leishmaniasis is endemic in 88 countries with incidence rate of 1.5-2 million; the most common form of leishmaniasis is cutaneous leishmaniasis (CL) with 1.5 million new cases per year. Correct diagnosis and characterization of the particular parasite is important for evaluating prognosis and prescribing appropriate treatment. The current management of leishmaniasis is drug treatment of patients, to alleviate disease and vector control to reduce its transmission. Also, current treatments for visceral leishmaniasis are unsatisfactory because of their toxicity, resistance and high cost. The purpose of the present study was to review the application of nano drugs in treatment of leishmaniasis. Materials and Methods:it was used as source of research the following databases: MEDLINE, Cochrane Library, Scielo, PubMed and the database of CAPES.Results: It has been proved nanosilver particles with highly small sizes, have a good penetration into the cutaneous lesions and a good efficacy on leishmaniasis.anti-leishmanial therapy [14][15][16][17]. Although glucantime is commonly used for the treatment of leishmaniasis, it has some side effects including increased liver enzymes and electrocardiogram changes [17]. In addition, the drug is expensive, the injection is painful, and research shows that resistance of parasite to glucantime is growing in different parts of the world [17][18][19][20]. The use of nanotechnology is ever-expanding in today's technologically advanced world. This form of technology has many advantages over existing ones in many fields and medicine is one of them [20]. There are numerous devices and mechanisms developed with the aid of nanotechnology that can help cure diseases/disorders in a much better and more efficient manner [21]. The usefulness of nanotechnology can especially be seen in the treatment of infectious diseases [21,22]. This review has investigated the treatment of leishmaniasis by nano drugs. Nano drugs against leishmaniasisNanotechnology must be applied for curing infectious disease like leishmaniasis [22]. Many drugs have been made and are still being discovered, but the protozoan re-emerges showing drug resistance to the effective medications [23]. Nanotechnology has just managed to show its promise in developing a liposomal formulation called amphotericin B for leishmaniasis but has serious side effects and is not cost effective in developing countries [23][24][25]. Initial, nanodelivery systems for delivering chemotherapeutics were nanodisks impregnanted with amphotericin B, polymericnanoparticle loaded with pentamidine, primaquine, and niosomes, which still need validation at the clinical level [25][26][27][28]. There is an urgent need to take up assignments to use effective nanotechnology devices in combating this infectious disease [25][26][27][28].Different mechanisms were proposed for antimicrobial property of nanoparticles [28]. One mechanism is binding of nanoparticle to sulfur/ phosphorus-containing biomolecules such as proteins and DNA, which leads to...

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Application Of Nano Drugs In Treatment Of Leishmaniasismentioning

confidence: 99%

Section: Application Of Nano Drugs In Treatment Of Leishmaniasismentioning

confidence: 99%

Section: Application Of Nano Drugs In Treatment Of Leishmaniasismentioning

confidence: 99%

See 3 more Smart Citations

Application of Nano Drugs in Treatment of Leishmaniasis

Shahcheraghi¹

2016

Glob J Infect Dis Clin Res

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A comparison between two Pd‐Ni catalysts supported on two different supports toward Suzuki‐Miyaura coupling reaction

Taheri

Ghiaci

Shchukarev

2018

Applied Organom Chemis

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When a single metal fails to promote an efficient Suzuki-Miyaura coupling reaction at ambient temperature, the synergistic cooperation of two distinct metals might improve the reaction. To examine the synergistic effect of palladium and nickel for catalyzing Suzuki coupling reaction, g-C 3 N 4 supported metal nanoparticles of PdO, NiO and Pd-PdO-NiO were prepared, characterized and their catalytic activities evaluated over different aryl halides at room temperature and 78°C.The morphological characterization of Pd-PdO-NiO/g-C 3 N 4 demonstrated that the bimetallic particles were uniformly dispersed over the g-C 3 N 4 layers with diameters ranging from 3.5-7.7 nm. XPS analysis showed that nanoparticles of Pd-PdO-NiO consisted of Pd(II), Pd(0) and Ni(II) sites. The experiments performed on the catalytic activity of Pd-PdO-NiO/g-C 3 N 4 showed that the prepared catalyst demonstrated an efficient activity without using toxic solvents.

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Green synthesis and physiochemical characterization of nickel oxide nanoparticles: Interaction studies with Calf thymus DNA

2019

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One of the most promising applications of nanomaterials is that of nanobiosensors, using biomolecules such as nucleic acids as receptors. This study aimed to synthesize nickel oxide nanoparticles (NiO NPs) by an environmentally friendly green synthesis, using the extract of the herb Coriandrum sativum (coriander). The synthesized NPs were characterized using UV–Visible spectroscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, X‐ray photon spectroscopy, field emission scanning electron microscopy coupled with energy dispersive spectroscopy, dynamic light scattering, zeta potential and transmission electron microscopy. All results confirmed the synthesis of pure, spherical, positively charged NiO NPs of around 95 nm in diameter with prominent hydroxyl groups attached to the surface. Furthermore, interaction studies of synthesized NiO NPs with calf thymus DNA (CT DNA) were performed using UV–Visible spectroscopy, UV–thermal melting, circular dichroism, and fluorescence spectroscopy. CT DNA served as a substitute for nucleic acid biosensors. All experimental studies indicated that the NiO NPs bound electrostatically with CT DNA. These studies may facilitate exploring the potential of NiO NP–nucleic acid conjugated materials to be used as nanobiosensors for various applications, especially in pharmacological, epidemiological, and environmental diagnostic applications, and in detection.

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Nano-structured nickel oxide based DNA biosensor for detection of visceral leishmaniasis (Kala-azar)

Cited by 78 publications

References 51 publications

Application of Nano Drugs in Treatment of Leishmaniasis

Application of Nano Drugs in Treatment of Leishmaniasis

A comparison between two Pd‐Ni catalysts supported on two different supports toward Suzuki‐Miyaura coupling reaction

Green synthesis and physiochemical characterization of nickel oxide nanoparticles: Interaction studies with Calf thymus DNA

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