Nanobiocatalysis: Nanostructured materials – a minireview

Rostro-Alanís, Magdalena; Mancera-Andrade, Elena I.; Patiño, Mayra Beatriz Gómez; Arrieta-Báez, Daniel; Cardenas, Braulio; Martínez-Chapa, Sergio O.; Parra‐Saldívar, Roberto

doi:10.1515/boca-2016-0001

Cited by 48 publications

(20 citation statements)

References 161 publications

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“…New materials, with unexpected properties, are rapidly developing from nanotechnological techniques. One of the most promising areas is the design and production of biocatalytic nanoreactors based on the combination of the catalytic properties of enzymes and the unique characteristics of nano‐sized materials . This is, certainly, an opportunity to solve different challenges in industrial, environmental processes, and especially in biomedical treatments.…”

Section: Introductionmentioning

confidence: 99%

Biocatalytic virus capsid as nanovehicle for enzymatic activation of Tamoxifen in tumor cells

Tapia-Moreno

Juárez-Moreno

González-Davis

et al. 2017

Biotechnology Journal

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Most of the drugs used in chemotherapy should be activated by a transformation catalyzed by cytochrome P450 (CYP) enzymes. In this work, bacteriophage P22 virus-like particles (VLPs) containing CYP activity, immunologically inert and functionalized in order to be recognized by human cervix carcinoma cells and human breast adenocarcinoma cells were designed. The CYP was encapsulated inside the virus capsid obtained from the bacteriophage P22. CYP and coat protein were both heterologously expressed in E. coli. The VLPs with enzymatic activity were covered with polyethylene glycol that was functionalized in its distal end with folic acid in order to be recognized by folate receptors exhibited on tumor cells. The capacity of biocatalytic VLPs to be recognized and internalized into tumor cells is demonstrated. The VLP-treated cells showed enhanced capacity for the transformation of the pro-drug tamoxifen, which resulted in an increase of the cell sensitivity to this oncological drug. In this work, the potential use of biocatalytic VLPs vehicles as a delivery system of medical relevant enzymes is clearly demonstrated. In addition to cancer treatment, this technology also offers an interesting platform as nano-bioreactors for intracellular delivery of enzymatic activity for other diseases originated by the lack of enzymatic activity.

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Section: Introductionmentioning

confidence: 99%

Biocatalytic virus capsid as nanovehicle for enzymatic activation of Tamoxifen in tumor cells

Tapia-Moreno

Juárez-Moreno

González-Davis

et al. 2017

Biotechnology Journal

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“…Recently, the use of nanoparticles for transporting therapeutic enzymes has been reviewed. [143][144][145] These advancements, together with the improvement of catalytic activity of enzymes by molecular tools, seem to be a potential solution to contending with the large number of lethal OPP intoxications.…”

Section: Discussionmentioning

confidence: 99%

Enzymatic detoxification of organophosphorus pesticides and related toxicants

Alejo-González

Hanson-Viana

Vázquez-Duhalt

2018

Journal of Pesticide Science

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Millions of cases of pesticide intoxication occur yearly and represent a public health problem. In addition, pesticide poisoning is the preferred suicidal method in rural areas. The use of enzymes for the treatment of intoxication due to organophosphorus pesticides was proposed decades ago. Several enzymes are able to transform organophosphorus compounds such as pesticides and nerve agents. Some specific enzymatic treatments have been proposed, including direct enzyme injection, liposome and erythrocytes carriers, PEGylated preparations and extracorporeal enzymatic treatments. Nevertheless, no enzymatic treatments are currently available. In this work, the use of enzymes for treating of organophosphorus pesticide intoxication is critically reviewed and the remaining challenges are discussed.

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“…These macromolecules can attach to one particular molecule or analyte, but not others to ensure the analyte selectivity. Due to their high specificity, simplicity, and scalability, enzyme-based biosensors represent a fast, precise, and continuous monitoring of analytes [ 24 ]. Additionally, the high specificity of enzymes enhances the ability to detect lower analyte concentration limits [ 18 ].…”

Section: Enzyme Based Biosensorsmentioning

confidence: 99%

Enzyme (Single and Multiple) and Nanozyme Biosensors: Recent Developments and Their Novel Applications in the Water-Food-Health Nexus

et al. 2021

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The use of sensors in critical areas for human development such as water, food, and health has increased in recent decades. When the sensor uses biological recognition, it is known as a biosensor. Nowadays, the development of biosensors has been increased due to the need for reliable, fast, and sensitive techniques for the detection of multiple analytes. In recent years, with the advancement in nanotechnology within biocatalysis, enzyme-based biosensors have been emerging as reliable, sensitive, and selectively tools. A wide variety of enzyme biosensors has been developed by detecting multiple analytes. In this way, together with technological advances in areas such as biotechnology and materials sciences, different modalities of biosensors have been developed, such as bi-enzymatic biosensors and nanozyme biosensors. Furthermore, the use of more than one enzyme within the same detection system leads to bi-enzymatic biosensors or multi-enzyme sensors. The development and synthesis of new materials with enzyme-like properties have been growing, giving rise to nanozymes, considered a promising tool in the biosensor field due to their multiple advantages. In this review, general views and a comparison describing the advantages and disadvantages of each enzyme-based biosensor modality, their possible trends and the principal reported applications will be presented.

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Nanobiocatalysis: Nanostructured materials – a minireview

Cited by 48 publications

References 161 publications

Biocatalytic virus capsid as nanovehicle for enzymatic activation of Tamoxifen in tumor cells

Biocatalytic virus capsid as nanovehicle for enzymatic activation of Tamoxifen in tumor cells

Enzymatic detoxification of organophosphorus pesticides and related toxicants

Enzyme (Single and Multiple) and Nanozyme Biosensors: Recent Developments and Their Novel Applications in the Water-Food-Health Nexus

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