Nanobody Engineering: Computational Modelling and Design for Biomedical and Therapeutic Applications
Nehad El Salamouni,
Jordan Cater,
Lisanne Spenkelink
et al.
Abstract:Nanobodies, the smallest functional antibody fragment derived from camelid heavy-chain-only antibodies, have emerged as powerful tools for diverse biomedical applications. In this comprehensive review, we discuss the structural characteristics, functional properties, and computational approaches driving the design and optimisation of synthetic nanobodies. We explore their unique antigen-binding domains, highlighting the critical role of complementarity-determining regions in target recognition and specificity.… Show more
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