Nanobody-functionalized conduit with built-in static mixer for specific elimination of cytokines in hemoperfusion

Yao, Guangshuai; Ji, Fangling; Chen, Jiewen; Dai, Bingbing; Jia, Lingyun

doi:10.1016/j.actbio.2023.09.050

Acta Biomaterialia

2023

DOI: 10.1016/j.actbio.2023.09.050

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Nanobody-functionalized conduit with built-in static mixer for specific elimination of cytokines in hemoperfusion

Guangshuai Yao,

Fangling Ji,

Jiewen Chen

et al.

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Discovery of nanobodies: a comprehensive review of their applications and potential over the past five years

Alexander,

Leong

2024

J Nanobiotechnol

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Nanobodies (Nbs) are antibody fragments derived from heavy-chain-only IgG antibodies found in the Camelidae family as well as cartilaginous fish. Their unique structural and functional properties, such as their small size, the ability to be engineered for high antigen-binding affinity, stability under extreme conditions, and ease of production, have made them promising tools for diagnostics and therapeutics. This potential was realized in 2018 with the approval of caplacizumab, the world’s first Nb-based drug. Currently, Nbs are being investigated in clinical trials for a broad range of treatments, including targeted therapies against PDL1 and Epidermal Growth Factor Receptor (EGFR), cardiovascular diseases, inflammatory conditions, and neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. They are also being studied for their potential for detecting and imaging autoimmune conditions and infectious diseases such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A variety of methods are now available to generate target-specific Nbs quickly and efficiently at low costs, increasing their accessibility. This article examines these diverse applications of Nbs and their promising roles. Only the most recent articles published in the last five years have been used to summarize the most advanced developments in the field. Graphical Abstract

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Discovery of nanobodies: a comprehensive review of their applications and potential over the past five years

Alexander,

Leong

2024

J Nanobiotechnol

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show abstract

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Nanobody-functionalized conduit with built-in static mixer for specific elimination of cytokines in hemoperfusion

Cited by 1 publication

References 57 publications

Discovery of nanobodies: a comprehensive review of their applications and potential over the past five years

Discovery of nanobodies: a comprehensive review of their applications and potential over the past five years

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