Nanocarrier system: An emerging strategy for bioactive peptide delivery

Abstract

Compared with small-molecule synthetic drugs, bioactive peptides have desirable advantages in efficiency, selectivity, safety, tolerance, and side effects, which are accepted by attracting extensive attention from researchers in food, medicine, and other fields. However, unacceptable barriers, including mucus barrier, digestive enzyme barrier, and epithelial barrier, cause the weakening or the loss of bioavailability and biostability of bioactive peptides. The nanocarrier system for bioactive peptide delivery needs to be further probed. We provide a comprehensive update on the application of versatile delivery systems for embedding bioactive peptides, including liposomes, polymer nanoparticles, polysaccharides, hydrogels, and self-emulsifying delivery systems, and further clarify their structural characterization, advantages, and disadvantages as delivery systems. It aims to provide a reference for the maximum utilization of bioactive peptides. It is expected to be an effective strategy for improving the bioavailability and biostability of bioactive peptides.

Bioactive-Based Nanocarriers for Targeting and Treating Cancer

“…41 • Overcoming biological barriers: Nanocarriers can overcome biological barriers, such as the cell membrane and the extracellular matrix, allowing for efficient drug delivery to the tumor site. [42][43][44]…”

A critical review of a typical research system for food‐derived metal‐chelating peptides: Production, characterization, identification, digestion, and absorption

“…Consequently, the ions are rapidly converted into metal salt precipitates, which may lead to relatively inferior ion retention in the alkaline environment of the digestive tract (Wang, Zhang, et al., 2023; Zhang, Ding, et al., 2021). Thus, to improve the availabilities of metals under these conditions, numerous alternatives, including liposomes, polymer nanoparticles, polysaccharides, hydrogels, and self‐emulsifying delivery systems, to protect minerals have gradually evolved (Zhang et al., 2022). Among these delivery systems, although hydrogels demonstrate strong local drug penetrations, their mechanical strengths and specificities are inferior.…”

Thermodynamic and Kinetic Stability of Cosmetic Nanoemulsions

“…For example, due to their specific amino acid sequences, peptides exhibit the potential to stimulate collagen production and cellular regeneration, thereby offering promising anti-aging and skin-repair properties. Nanotechnology has been shown to be an effective strategy for improving the bioavailability and biostability of peptides [12].…”