Nanocarriers with ultrahigh chromophore loading for fluorescence bio-imaging and photodynamic therapy

Navarro, Julien R. G.; Lerouge, Frédéric; Cepraga, Cristina; Micouin, Guillaume; Favier, Arnaud; Château, Denis; Charreyre, Marie‐Thérèse; Lanoë, Pierre‐Henri; Monnereau, Cyrille; Chaput, Frédéric; Marotte, Sophie; Leverrier, Yann; Marvel, Jacqueline; Kamada, Kei; Andraud, Chantal; Baldeck, Patrice L.; Parola, Stéphane

doi:10.1016/j.biomaterials.2013.07.032

Cited by 60 publications

(41 citation statements)

References 49 publications

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“…[443] The optimized nanostructures were successfully used for cell imaging and photodynamic therapy of cancer cells. [443] Interestingly, it was also shown that the use of anisotropic gold core, such as nanobipyramids, allowed enhancement of the fluorescence while this was not observed in the case of the spherical nanoparticles. [444] The distances of interactions can be also tuned by using charged spacers such as polyelectrolytes for surface modifi- Figure 36.…”

Section: Q15mentioning

confidence: 99%

“…The synthesis of block copolymers bearing chromophores along the chains showed efficient control over the distance by playing with the polymer structure. [443,444] The copolymer functionalized with Lucifer Yellow (LY) allowed preparation of luminescent gold hybrid nanostructure ( Figure 36). [443] The optimized nanostructures were successfully used for cell imaging and photodynamic therapy of cancer cells.…”

Section: Q15mentioning

confidence: 99%

“…[443,444] The copolymer functionalized with Lucifer Yellow (LY) allowed preparation of luminescent gold hybrid nanostructure ( Figure 36). [443] The optimized nanostructures were successfully used for cell imaging and photodynamic therapy of cancer cells. [443] Interestingly, it was also shown that the use of anisotropic gold core, such as nanobipyramids, allowed enhancement of the fluorescence while this was not observed in the case of the spherical nanoparticles.…”

Section: Q15mentioning

confidence: 99%

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Optical Properties of Hybrid Organic‐Inorganic Materials and their Applications

Parola

Julián‐López

Carlos

et al. 2016

Adv Funct Materials

Self Cite

251

116

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Research on hybrid inorganic‐organic materials has experienced an explosive growth since the 1980s, with the expansion of soft inorganic chemistry based processes. Indeed, mild synthetic conditions, low processing temperatures provided by “chimie douce” and the versatility of the colloidal state allow for the mixing of the organic and inorganic components at the nanometer scale in virtually any ratio to produce the so called hybrid materials. Today a high degree of control over both composition and nanostructure of these hybrids can be achieved allowing tunable structure‐property relationships. This, in turn, makes it possible to tailor and fine‐tune many properties (mechanical, optical, electronic, thermal, chemical…) in very broad ranges, and to design specific multifunctional systems for applications. In particular, the field of “Hybrid‐Optics” has been very productive not only scientifically but also in terms of applications. Indeed, numerous optical devices based on hybrids are already in, or very close, to the market. This review describes most of the recent advances performed in this field. Emphasis will be given to luminescent, photochromic, NLO and plasmonic properties. As an outlook we show that the controlled coupling between plasmonics and luminescence is opening a land of opportunities in the field of “Hybrid‐Optics”.

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Section: Q15mentioning

confidence: 99%

Section: Q15mentioning

confidence: 99%

Section: Q15mentioning

confidence: 99%

See 1 more Smart Citation

Optical Properties of Hybrid Organic‐Inorganic Materials and their Applications

Parola

Julián‐López

Carlos

et al. 2016

Adv Funct Materials

Self Cite

251

116

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“…Although researches on the delivery system of photosensitizers have flourished in recent years, low enriching efficiency of photosensitizers still severely hamper the therapeutic effect of PDT. 15,16 In these researches, photosensitizer dose is always too large to guarantee the therapeutic effect in clinics, which increases potential phototoxicity to the normal tissues. Specificity and controllability of some photpsensitizers at the tumor site have been performed to improve retention; herein, we fabricated a novel magnetic mesoporous silica nanoparticle (MMSN) to deliver photosensitizer to the target site using the magnetic targeting technology.…”

mentioning

confidence: 99%

Magnetic and pH dual-responsive mesoporous silica nanocomposites for effective and low-toxic photodynamic therapy

Zhan¹,

Ma²,

Wang³

et al. 2017

IJN

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Nonspecific targeting, large doses and phototoxicity severely hamper the clinical effect of photodynamic therapy (PDT). In this work, superparamagnetic Fe 3 O 4 mesoporous silica nanoparticles grafted by pH-responsive block polymer polyethylene glycol- b -poly(aspartic acid) (PEG- b -PAsp) were fabricated to load the model photosensitizer rose bengal (RB) in the aim of enhancing the efficiency of PDT. Compared to free RB, the nanocomposites (polyethylene glycol- b -polyaspartate-modified rose bengal-loaded magnetic mesoporous silica [RB−MMSNs]) could greatly enhance the cellular uptake due to their effective endocytosis by mouse melanoma B16 cell and exhibited higher induced apoptosis although with little dark toxicity. RB−MMSNs had little dark toxicity and even much could be facilitated by magnetic field in vitro. RB−MMSNs demonstrated 10 times induced apoptosis efficiency than that of free RB at the same RB concentration, both by cell counting kit-8 (CCK-8) result and apoptosis detection. Furthermore, RB−MMSNs-mediated PDT in vivo on tumor-bearing mice showed steady physical targeting of RB−MMSNs to the tumor site; tumor volumes were significantly reduced in the magnetic field with green light irradiation. More importantly, the survival time of tumor-bearing mice treated with RB−MMSNs was much prolonged. Henceforth, polyethylene glycol- b -polyaspartate-modified magnetic mesoporous silica (MMSNs) probably have great potential in clinical cancer photodynamic treatment because of their effective and low-toxic performance as photosensitizers’ vesicles.

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“…The synthesis of block copolymers bearing chromophores along the chains showed efficient control over the distance by playing with the polymer structure. 181,182 The copolymer functionalized with Lucifer Yellow (LY) allowed preparation of luminescent gold hybrid nanostructure (Fig. 11).…”

Section: Technology Driven Exploration Of Hybrid Materialsmentioning

confidence: 99%

Review—Organic-Inorganic Hybrid Functional Materials: An Integrated Platform for Applied Technologies

Mir

Nagahara

Thundat

et al. 2018

J. Electrochem. Soc.

317

156

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Hybrid functional materials, constituting both inorganic and organic components, are considered potential platforms for applications in extremely diverse fields such as optics, micro-electronics, transportation, health, energy, energy storage, diagnosis, housing, environment and the highly relevant area is Internet of Things (IoT). Material properties of hybrid materials can be tuned by modification of the composition on the molecular scale to produce smart materials. Cross-cutting approaches, to synergistically couple molecular engineering and processing allows to tailor complex hybrid systems of various shapes with perfect control over size, composition, functionality, and morphology. The detailed description and discussion of variety of hybrid functional organicinorganic materials and their contribution in the designing of specific modern technologies is the prime focus of this review. There is an enormous demand for hybrid materials to provide technological breakthroughs with the most sought after being the enabling of the IoT. Interest in the field of IoT will witness exponential growth over the next decade as markets realize the true potential of realtime data acquisition for various entertainment, knowledge dissemination, defense, environmental, and healthcare applications. Many of the well-established materials, such as metals, 1 ceramics, 2-4 or plastics 5,6 cannot fulfill all technological desires for the various new applications. In addition to the early interest in structural hybrid materials based on carbon-silicon networks, many recent efforts have centered on the design of functional hybrid materials which harness the chemical activity of their components. This approach has been successfully used in recent years in the design of hybrid polymers 7 with special emphasis on structural hybrid materials based on mixed silicon-carbon networks prepared by sol-gel methods [8][9][10][11][12] which can also entrap additional active species. 13 In this field the stakes are high and scientists aim at producing structural materials with properties between those of inorganic glasses and organic polymers.8 But the expectations go beyond mechanical strength and thermal and chemical stability. These new materials are also sought for improved optical, 14-17 and electrical 18,19 properties, luminescence, 12,20-25 ionic conductivity, [26][27][28] and selectivity, 29-32 as well as chemical [33][34][35] or biochemical 36-38 activity. Chemical activity is of core importance in functional materials. Sensors, selective membranes, all sorts of electrochemical devices, from actuators to batteries or supercapacitors, supported catalysts or photoelectrochemical energy conversion cells are some important devices based on hybrid functional materials.Hybridization is a multifaceted strategy. In some cases, conducting organic polymers act just as a solid polymeric support for active species, whereas in other hybrid systems the activity of organic and inorganic species combines to reinforce or modify each other. But in every case ...

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Nanocarriers with ultrahigh chromophore loading for fluorescence bio-imaging and photodynamic therapy

Cited by 60 publications

References 49 publications

Optical Properties of Hybrid Organic‐Inorganic Materials and their Applications

Optical Properties of Hybrid Organic‐Inorganic Materials and their Applications

Magnetic and pH dual-responsive mesoporous silica nanocomposites for effective and low-toxic photodynamic therapy

Review—Organic-Inorganic Hybrid Functional Materials: An Integrated Platform for Applied Technologies

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