Nanocellulose based hydrogel or aerogel scaffolds for tissue engineering

Wei, Zhenke; Wu, Chaojun; Li, Ronggang; Yu, Dunji; Ding, Qijun

doi:10.1007/s10570-021-04021-3

Cited by 41 publications

(18 citation statements)

References 125 publications

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“…In general, hydrogels represent hydrophilic 3D networks composed of water-soluble natural (e.g., polysaccharides and proteins) and/or synthetic polymers crosslinked by chemical or physical methods to form a water-insoluble matrix [ 13 , 14 ]. Different from hydrogels, aerogels are porous materials obtained when the liquid phase of a hydrogel is replaced by a gas, while preserving the internal structure and the surface area of the initial hydrogel [ 15 , 16 , 17 ]. They have been proven to provide highly desirable 3D environments for the regeneration of the cartilaginous tissue, as shown by in vitro and in vivo studies [ 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

RGD-Functionalized Hydrogel Supports the Chondrogenic Commitment of Adipose Mesenchymal Stromal Cells

Manferdini

Trucco

Saleh

et al. 2022

Gels

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Articular cartilage is known to have limited intrinsic self-healing capacity when a defect or a degeneration process occurs. Hydrogels represent promising biomaterials for cell encapsulation and injection in cartilage defects by creating an environment that mimics the cartilage extracellular matrix. The aim of this study is the analysis of two different concentrations (1:1 and 1:2) of VitroGel® (VG) hydrogels without (VG-3D) and with arginine-glycine-aspartic acid (RGD) motifs, (VG-RGD), verifying their ability to support chondrogenic differentiation of encapsulated human adipose mesenchymal stromal cells (hASCs). We analyzed the hydrogel properties in terms of rheometric measurements, cell viability, cytotoxicity, and the expression of chondrogenic markers using gene expression, histology, and immunohistochemical tests. We highlighted a shear-thinning behavior of both hydrogels, which showed good injectability. We demonstrated a good morphology and high viability of hASCs in both hydrogels. VG-RGD 1:2 hydrogels were the most effective, both at the gene and protein levels, to support the expression of the typical chondrogenic markers, including collagen type 2, SOX9, aggrecan, glycosaminoglycan, and cartilage oligomeric matrix protein and to decrease the proliferation marker MKI67 and the fibrotic marker collagen type 1. This study demonstrated that both hydrogels, at different concentrations, and the presence of RGD motifs, significantly contributed to the chondrogenic commitment of the laden hASCs.

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Section: Introductionmentioning

confidence: 99%

RGD-Functionalized Hydrogel Supports the Chondrogenic Commitment of Adipose Mesenchymal Stromal Cells

Manferdini

Trucco

Saleh

et al. 2022

Gels

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“…Therefore, mechanically strong material is the requirement to be used in biomaterials applications such as scaffolds for tissue engineering. Various studies have been reported to improve the mechanical properties of soft tissue scaffolds, and they achieve modulus ranging from KPa to MPa [ 52 ]. In a study, silk fibers were used as reinforcement to improve the mechanical properties of gellan gum hydrogel, but could achieve a maximum of 0.4 MPa modulus [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Alginate Hydrogel Fibers Reinforced by Cotton for Biomedical Applications

Azam

Ahmad

et al. 2022

Polymers

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In this study, cotton-reinforced alginate hydrogel fibers were successfully synthesized using the wet spinning technique to improve hydrogel fibers’ mechanical strength and durability. Structural, chemical, and mechanical properties of the prepared fibers were characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray Diffraction, differential scanning calorimeter, and single fiber strength tester. Based on the results obtained from fourier transform infrared spectroscopy and x-ray Diffraction, cotton fibers have been successfully incorporated into the structure of the hydrogel fibers. It was seen from the differential scanning calorimeter results that the incorporation of fibers in the structure even enhanced the thermal stability of the fiber and is viable to be implanted in the human body. Cotton reinforcement in alginate hydrogel fibers increases the modulus up to 56.45 MPa providing significant stiffness and toughness for the hydrogel composite fiber. The tenacity of the fibers increased by increasing the concentration of alginate from 2.1 cN/Tex (1% w/v) to 8.16 cN/Tex (1.5% w/v). Fiber strength increased by 26.75% and water absorbance increased by 120% by incorporating (10% w/w) cotton fibers into the fibrous structure. It was concluded that these cotton-reinforced alginate hydrogel fibers have improved mechanical properties and liquid absorption properties suitable for use in various biomedical applications.

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“…Nanocellulose are used for the adsorption of residual antibiotics present in the industrial effluents, aquaculture system and in medical discharge wastes. The following are the various modifications that contribute to the bio adsorbent property of nanocellulose [ 32 , 43 ].…”

Section: Mechanism Of Nanocellulose In Bioremediationmentioning

confidence: 99%