2022
DOI: 10.3390/cryst12111565
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Nanocrystal-Based Topical Gels for Improving Wound Healing Efficacy of Curcumin

Abstract: Topical curcumin shows poor local availability because of its low aqueous solubility and inadequate tissue absorption. Curcumin nanocrystals were prepared by sonoprecipitation followed by lyophilization to improve surface area and solubility. The formulation was optimized by the Design of Experiment (DoE) approach. The nanocrystals were characterized for particle size, zeta potential, polydispersity index, scanning electron microscopy (SEM), powder x-ray diffraction (PXRD), practical yield and in vitro drug re… Show more

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Cited by 10 publications
(5 citation statements)
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“…The research has also highlighted curcumin’s promise in wound healing applications [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 100 , 101 , 102 , 119 ]. Various formulations have shown positive effects in wound healing, making curcumin gel a valuable option for managing oral aphthous ulcers.…”
Section: Discussionmentioning
confidence: 99%
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“…The research has also highlighted curcumin’s promise in wound healing applications [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 100 , 101 , 102 , 119 ]. Various formulations have shown positive effects in wound healing, making curcumin gel a valuable option for managing oral aphthous ulcers.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, advancements in formulation techniques have facilitated the development of curcumin-based delivery systems with improved efficacy. Kotian et al prepared curcumin nanocrystals and incorporated them into a gel, resulting in enhanced drug release, skin permeation, and wound healing activity compared to unprocessed curcumin without causing skin irritation [ 49 ]. Pisitsak and Ruktanonchai embedded curcumin in a sol–gel coating on cotton textiles, which exhibited controlled release and antibacterial properties, suggesting their potential as wound dressing materials [ 50 ].…”
Section: Curcumin Delivery Systemsmentioning
confidence: 99%
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“…To get around these several limitations, nanotechnological systems such as nanoemulsions [ 17 ], microemulsions [ 18 ], self-nanoemulsifying systems [ 19 ], nanoparticles [ 20 ], nanoliposomes [ 21 ], micelles [ 22 ], and nanocrystals [ 23 ] have been utilized. These systems can promote (i) protection of the drug against degradation in physiological media, (ii) increase in drug solubility, and (iii) modification/targeting of the drug enabling transport through biological membranes [ 13 , 24 ].…”
Section: Introductionmentioning
confidence: 99%