Nanocrystals: A perspective on translational research and clinical studies

Jarvis, Maria; Krishnan, Vinu; Mitragotri, Samir

doi:10.1002/btm2.10122

Cited by 101 publications

(42 citation statements)

References 124 publications

(188 reference statements)

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“…Some poorly soluble drugs have been salvaged through formulating nanocrystal. Nanocrystals possess unique traits such as the increased surface area to volume ratio, steady dissolution rates, enhanced structural stability, and high drug-loading efficiency, due to nanocrystals consisting of entirely of the drug or payload, thereby eliminating the ancillary role of a carrier and resulting in satisfactory therapeutic concentrations at low dose [ 46 ]. Nanocrystals were originally used to enhance the oral bioavailability of low-soluble drugs.…”

Section: Development Of Nano-sized Delivery Systems For Solid Cancmentioning

confidence: 99%

“…The particle size, morphology, and surface modification of nanocrystals have a great influence on their distribution in vivo. The size, stability, solubility, and bioavailability of nanocrystals are often affected by the pH of the dispersed medium, impurities formed during manufacturing, as well as the crystallinity [ 46 ].…”

Section: Development Of Nano-sized Delivery Systems For Solid Cancmentioning

confidence: 99%

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Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Wei

Lau

2020

Cancers

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Conventional chemotherapy is still an important option of cancer treatment, but it has poor cell selectivity, severe side effects, and drug resistance. Utilizing nanoparticles (NPs) to improve the therapeutic effect of chemotherapeutic drugs has been highlighted in recent years. Nanotechnology dramatically changed the face of oncology by high loading capacity, less toxicity, targeted delivery of drugs, increased uptake to target sites, and optimized pharmacokinetic patterns of traditional drugs. At present, research is being envisaged in the field of novel nano-pharmaceutical design, such as liposome, polymer NPs, bio-NPs, and inorganic NPs, so as to make chemotherapy effective and long-lasting. Till now, a number of studies have been conducted using a wide range of nanocarriers for the treatment of solid tumors including lung, breast, pancreas, brain, and liver. To provide a reference for the further application of chemodrug-loaded nanoformulations, this review gives an overview of the recent development of nanocarriers, and the updated status of their use in the treatment of several solid tumors.

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Section: Development Of Nano-sized Delivery Systems For Solid Cancmentioning

confidence: 99%

Section: Development Of Nano-sized Delivery Systems For Solid Cancmentioning

confidence: 99%

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Wei

Lau

2020

Cancers

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“…Nanocrystals in other words crystalline NPs, composed of very stabilized drugs, are advantageous drug delivery systems that increase dissolution velocity, saturation solubility, and adhesiveness to surfaces/cell membranes by enlargement of surface area of poor soluble drug molecules. 155 Different types of materials such as hydroxyapatite, 156 lanthanide, 157 cellulose, 158 paclitaxel, 159 quantum dot, 160 or magnetite 161 can be used for producing nanocrystal formulation. Nanocrystal drug products such as Rapamune Ò , Cesamet Ò , Avinza Ò , Triglide Ò , and Invega Sustenna Ò are approved for the prophylaxis of organ rejection, in the treatment of hypercholesterolemia, depression, nausea, or chronic pain taken orally or parentally.…”

Section: Nanocrystalsmentioning

confidence: 99%

Targeted Alpha Therapy and Nanocarrier Approach

Silindir-Gunay

Karpuz

Özer

2020

Cancer Biotherapy and Radiopharmaceuticals

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The rates of cancer incidence and mortality are increasing day by day. Although several conventional methods including surgery, chemotherapy, and radiotherapy (RT) exist for cancer treatment, they are insufficient in the eradication of all tumor tissues and have some side-effects such as narrow therapeutic index and serious sideeffects to healthy tissues. Moreover, it may probably recur in time due to the survival and spreading of cancerous cells or any possible metastases. Targeted radionuclide therapy is a promising alternative. a particles are ideal for localized cell killing because of their high linear energy transfer and short ranges. However, upon emission of a particles, the daughter nuclides induce a recoil energy to lead decoupling from any chemical bond that may accumulate in normal tissues. Targeted a therapy can also be performed by targeted delivery systems apart from mAb, mAb fragments, peptides, and small molecules for selective tumor therapy. Targeted drug delivery systems have been developed to overcome the limitations of a therapy. Moreover, drug delivery systems are one of the most searched applications in cancer imaging and/or treatment due to their targeting ability to tumor or biocompatibility properties. The aim of this article is to summarize tumor therapy applications, targeted a RT approach, and to review the role of drug delivery systems in the delivery of a particles for cancer therapy and some instances of targeted a-emitting drug delivery systems from the literature.

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“…21 Along with original research articles, we also published reviews on some of the active current topics in translational medicine including ionic liquids for biomedical applications, 22 clinical landscape of nanomedicine, 23 and translational status of nanocrystals. 24 Thank you all for your strong support to the journal and look forward to your continued support in coming years.…”

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confidence: 98%

“…Papers on medical devices included control algorithms for artificial pancreas 21 . Along with original research articles, we also published reviews on some of the active current topics in translational medicine including ionic liquids for biomedical applications, 22 clinical landscape of nanomedicine, 23 and translational status of nanocrystals 24 . Reviews in BioTM are particularly focused on reporting translational advances and hurdles in the field.…”

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confidence: 99%

Bioengineering & Translational Medicine: Year 2020 in review

Mitragotri

2020

Bioengineering & Transla Med

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Huge thanks to all BioTM authors who trusted the journal with their precious manuscripts in the early, unproven days. Submission of high-quality manuscripts is the principal reason that led to an impressive launching impact factor. BioTM welcomes manuscripts in all aspects of bioengineering including drug delivery, drug discovery and development, tissue engineering, synthetic biology, biosensors, organoids and organ-mimetic systems, stem cell therapies, gene therapies, immunotherapies, patient-targeted therapies, medical devices, regenerative medicine, implant/patient interface, computational modeling, and bioinformatics. Areas including drug delivery, gene therapy, sirRNA delivery, regenerative medicine, nanomedicine, biomedical devices, and cell therapy have been particularly well represented in the manuscripts recently submitted to BioTM. This is expected because these fields represent some of the most active research areas at the interface of medicine and engineering, especially those that focus on developing/

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Nanocrystals: A perspective on translational research and clinical studies

Cited by 101 publications

References 124 publications

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Targeted Alpha Therapy and Nanocarrier Approach

Bioengineering & Translational Medicine: Year 2020 in review

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