Nanodelivery Systems for Topical Management of Skin Disorders

Cui, Mingyue; Wiraja, Christian; Chew, Sharon Wan Ting; Xu, Chen

doi:10.1021/acs.molpharmaceut.0c00154

Cited by 39 publications

(24 citation statements)

References 152 publications

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“…The skin structure comprises three main layers; epidermis, dermis, and hypodermis [83]. The epidermis mainly consists of keratinocytes and is where the binding of pharmaceutical compounds, metabolism, and active transport occurs [116]. Below the epidermis is a layer of connective tissue composed of fibroblasts, namely the dermis, responsible for the structure and elasticity of the skin [117].…”

Section: Challenges Of Antimicrobial Treatment and Delivery To The Skinmentioning

confidence: 99%

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

2021

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Chitosan is one of the most studied natural origin polymers for biomedical applications. This review focuses on the potential of chitosan in localized antimicrobial therapy to address the challenges of current rising antimicrobial resistance. Due to its mucoadhesiveness, chitosan offers the opportunity to prolong the formulation residence time at mucosal sites; its wound healing properties open possibilities to utilize chitosan as wound dressings with multitargeted activities and more. We provide an unbiased overview of the state-of-the-art chitosan-based delivery systems categorized by the administration site, addressing the site-related challenges and evaluating the representative formulations. Specifically, we offer an in-depth analysis of the current challenges of the chitosan-based novel delivery systems for skin and vaginal infections, including its formulations optimizations and limitations. A brief overview of chitosan’s potential in treating ocular, buccal and dental, and nasal infections is included. We close the review with remarks on toxicity issues and remaining challenges and perspectives.

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Section: Challenges Of Antimicrobial Treatment and Delivery To The Skinmentioning

confidence: 99%

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

2021

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“…Topical delivery of antifungal agents has been the traditional approach for fungal infections of the nails/toenails, corneas, mucous membranes, and skin. It has advantages such as low systemic toxicity, site-specific drug delivery, and better patient compliance. − Therefore, we next examined the in vivo antifungal efficacy of 22h for treating cutaneous or subcutaneous fungal infections using in vivo murine model. , When C. albicans was injected subcutaneously at the back of the shaved thigh, inflammation was induced within a day, which resulted in the sloughing off of the epidermal keratin layer (Figure A).…”

Section: Resultsmentioning

confidence: 99%

Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection

et al. 2021

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Due to the increased morbidity and mortality by fungal infections and the emergence of severe antifungal resistance, there is an urgent need for new antifungal agents. Here, we screened for antifungal activity in our in-house library through the minimum inhibitory concentration test and derived two hit compounds with moderate antifungal activities. The hit compounds’ antifungal activities and drug-like properties were optimized by substituting various aryl ring, alkyl chain, and methyl groups. Among the optimized compounds, 22h was the most promising candidate with good drug-like properties and exhibited potent fast-acting fungicidal antifungal effects against various fungal pathogens and synergistic antifungal activities with some known antifungal drugs. Additionally, 22h was further confirmed to disturb fungal cell wall integrity by activating multiple cell wall integrity pathways. Furthermore, 22h exerted significant antifungal efficacy in both the subcutaneous infection mouse model and ex vivo human nail infection model.

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“…Moreover, the alliance of 3D printing and nanotechnology has been widely explored in the biomedical area in the last years and can improve pharmaceutical dosage forms [8]. Nanotechnology plays a prominent role in developing more complex drug release profiles, and in targeting specific pharmacological therapy [165]. Wang et al (2020) explored 3D printed hydrogel loaded with cryptotanshinone (CPT) niosomes for topical therapy of acne.…”

Section: Drugsmentioning

confidence: 99%

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

et al. 2021

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3D printing has been widely used for the personalization of therapies and on-demand production of complex pharmaceutical forms. Recently, 3D printing has been explored as a tool for the development of topical dosage forms and wound dressings. Thus, this review aims to present advances related to the use of 3D printing for the development of pharmaceutical and biomedical products for topical skin applications, covering plain dressing and products for the delivery of active ingredients to the skin. Based on the data acquired, the important growth in the number of publications over the last years confirms its interest. The semisolid extrusion technique has been the most reported one, probably because it allows the use of a broad range of polymers, creating the most diverse therapeutic approaches. 3D printing has been an excellent field for customizing dressings, according to individual needs. Studies discussed here imply the use of metals, nanoparticles, drugs, natural compounds and proteins and peptides for the treatment of wound healing, acne, pain relief, and anti-wrinkle, among others. The confluence of 3D printing and topical applications has undeniable advantages, and we would like to encourage the research groups to explore this field to improve the patient’s life quality, adherence and treatment efficacy.

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Nanodelivery Systems for Topical Management of Skin Disorders

Cited by 39 publications

References 152 publications

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

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