Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin

Manconi, Maria; Manca, Maria Letizia; Caddeo, Carla; Valenti, Donatella; Cencetti, Claudia; Dı́ez-Sales, Octavio; Nácher, Amparo; Mir-Palomo, Silvia; Terencio, María Carmen; Demurtas, Davide; Gómez‐Fernández, Juan C.; Aranda, Francisco J.; Fadda, Anna Maria; Matricardi, Pietro

doi:10.1016/j.nano.2017.12.001

Cited by 53 publications

(17 citation statements)

References 47 publications

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“…The possibility of modulating the anti-inflammatory action by incorporating an active agent into liposomes is being established [43,44] and there are reports [45] describing the production of phospholipid vesicles containing bromelain or papain without impairing the proteolytic activity, thus we envision future studies to produce nanoparticles containing P1G10 for treatment of inflammatory symptoms.…”

Section: Discussionmentioning

confidence: 99%

P1G10, the Proteolytic Fraction from Vasconcellea cundinamarcensis, Stimulates Tissue Repair after Acute Exposure to Ultraviolet B Radiation

Freitas

Silva

Veloso

et al. 2019

IJMS

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Background: P1G10 is a cysteine proteolytic fraction from Vasconcellea cundinamarcensis latex, obtained by chromatographic separation on Sephadex-G10 and ultrafiltration. This fraction enhances healing in different models of skin lesions, and displays a protective/healing effect against gastric ulcers, where it was suggested an antioxidant role. Methods: We evaluated here the effect of topical treatment with P1G10, in mice lesions induced by UVB. Results: After single exposure to 2.4 J cm−2 UVB, P1G10 reduced erythema, increased cellularity of hypodermis, enhanced MPO activity and IL1β, and inhibited COX2 levels. These results point to an anti-inflammatory effect by P1G10. This fraction displayed antioxidant activity by reversing the depletion of glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and reducing the catalase activity increased by UVB. These changes may be related to a reduction in MDA observed in groups treated with P1G10. P1G10 also inhibited MMP-9, caspase-3 and pkat while increasing p53 levels.

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Section: Discussionmentioning

confidence: 99%

P1G10, the Proteolytic Fraction from Vasconcellea cundinamarcensis, Stimulates Tissue Repair after Acute Exposure to Ultraviolet B Radiation

Freitas

Silva

Veloso

et al. 2019

IJMS

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“…It was fully confirmed that the elastic liposomes cooperated with growth factor complex, synergistically exerting both rapid and prolonged effects on promoting chronic wound healing. A new self-assembling core–shell gellan-transfersome loading baicalin was designed by Manconi et al [48], they found out that novel transfersomes showed a relatively high skin drug deposition, about 11% of baicalin was retained in the whole skin, 8% of which was in the dermis, considered to be quite efficient. Daily application of baicalin transfersomes in mice model brought about complete skin restoration and inhibition of inflammatory markers such as oedema, TNF-α and IL-1β.…”

Section: Nano-drug Delivery System In Wound Treatment and Skin Regenementioning

confidence: 99%

Nano-drug delivery systems in wound treatment and skin regeneration

Wang¹,

Lu²,

Yu³

et al. 2019

J Nanobiotechnol

290

174

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Skin damages are defined as one of most common lesions people suffer from, some of wounds are notoriously difficult to eradicate such as chronic wounds and deep burns. Existing wound therapies have been proved to be inadequate and far from satisfactory. The cutting-edge nanotechnology offers an unprecedented opportunity to revolutionize and invent new therapies or boost the effectiveness of current medical treatments. In particular, the nano-drug delivery systems anchor bioactive molecules to applied area, sustain the drug release and explicitly enhance the therapeutic efficacies of drugs, thus making a fine figure in field relevant to skin regeneration. This review summarized and discussed the current nano-drug delivery systems holding pivotal potential for wound healing and skin regeneration, with a special emphasis on liposomes, polymeric nanoparticles, inorganic nanoparticles, lipid nanoparticles, nanofibrous structures and nanohydrogel.

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“…Baicalin and berberine were selected as curative agents due to their antioxidant, anti-inflammatory and proliferative effects. [76][77][78] In vitro studies showed that preparation enhanced permeation of drugs and antioxidants. Photoprotective effect evaluations showed that co-loaded vesicles increased melanin and tyrosinase activities.…”

Section: Nano-drug Delivery System In the Treatment Of Vitiligomentioning

confidence: 99%

<p>Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo</p>

Sun

Lou

et al. 2020

IJN

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Vitiligo is a depigmentation disease that seriously affects the physical health, mental health and quality of life of a patient. Therapeutic aim at control immunoreaction by relieving oxidative stress. Unfortunately, the cuticle barrier function and lack of specific accumulation lead to unsatisfactory therapeutic outcomes and side effects. The introduction and innovation of nanotechnology offers inspiration and clues for the development of new strategies to treat vitiligo. However, not many studies have been done to interrogate how nanotechnology can be used for vitiligo treatment. In this review, we summarize and analyze recent studies involving nano-drug delivery systems for the treatment of vitiligo, with a special emphasis on liposomes, niosomes, nanohydrogel and nanoparticles. These studies made significant progress by either increasing drug loading efficiency or enhancing penetration. Based on these studies, there are three proposed principles for topical nano-drug delivery systems treatment of vitiligo including the promotion of transdermal penetration, enhancement of drug retention and facilitation of melanin regeneration. The presentation of these ideas may provide inspirations for the future development of topical drug delivery systems that will conquer vitiligo.

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Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin

Cited by 53 publications

References 47 publications

P1G10, the Proteolytic Fraction from Vasconcellea cundinamarcensis, Stimulates Tissue Repair after Acute Exposure to Ultraviolet B Radiation

P1G10, the Proteolytic Fraction from Vasconcellea cundinamarcensis, Stimulates Tissue Repair after Acute Exposure to Ultraviolet B Radiation

Nano-drug delivery systems in wound treatment and skin regeneration

<p>Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo</p>

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