Nanodiamonds and gold nanoparticles to obtain a hybrid nanostructure with potential applications in biomedicine

Abstract

Using detonation nanodiamonds and fluorescent nitrogen-vacancy center nanodiamonds, linked to gold nanoparticles, we synthesized two hybrid nanostructures (HGDs) that were subsequently conjugated with a fluorophore. An amplification effect induced by the gold nanoparticles increased the emission spectrum of the fluorophore, maximizing the possibilities for imaging applications of these HGDs. The incubation of the nanostructures with HeLa cells produced no alteration of cell viability after 3 h and showed the presence of nanostructures in the cell cytoplasm at 24 h. These observations also indicate the potential biomedical use of the proposed HGDs.

The Use of Capping Agents in the Stabilization and Functionalization of Metallic Nanoparticles for Biomedical Applications

“…In addition, AuNPs are excellent transducers of absorbed radiation into heat, favoring their application in thermal phototherapy of cancer. [36] Also, the AuNP surface interact with active groups, such as thiols what makes possible a high level of biofunctionalization, [8,37] useful for drug release applications. Other studied metal ion particles, include copper, nickel, and platinum.…”