Nanoemulsion-based film formulation for transdermal delivery of carvedilol

Alkilani, Ahlam Zaid; Hamed, Rania; Al-Marabeh, Sara; Kamal, Areej; Abu‐Huwaij, Rana; Hamad, Islam

doi:10.1016/j.jddst.2018.05.015

Cited by 41 publications

(17 citation statements)

References 36 publications

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“…The thermodynamic stability of C. acaulis EO NE was evaluated through a three phases (centrifugation, heating/cooling cycles, and freeze/thaw cycles) test, according to the protocol reported by Alkilani et al [ 74 ] with some modifications.…”

Section: Methodsmentioning

confidence: 99%

Developing a Highly Stable Carlina acaulis Essential Oil Nanoemulsion for Managing Lobesia botrana

et al. 2020

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The growing interest in the development of green pest management strategies is leading to the exploitation of essential oils (EOs) as promising botanical pesticides. In this respect, nanotechnology could efficiently support the use of EOs through their encapsulation into stable nanoformulations, such as nanoemulsions (NEs), to improve their stability and efficacy. This technology assures the improvement of the chemical stability, hydrophilicity, and environmental persistence of EOs, giving an added value for the fabrication of natural insecticides effective against a wide spectrum of insect vectors and pests of public and agronomical importance. Carlina acaulis (Asteraceae) root EO has been recently proposed as a promising ingredient of a new generation of botanical insecticides. In the present study, a highly stable C. acaulis-based NE was developed. Interestingly, such a nanosystem was able to encapsulate 6% (w/w) of C. acaulis EO, showing a mean diameter of around 140 nm and a SOR (surfactant-to-oil ratio) of 0.6. Its stability was evaluated in a storage period of six months and corroborated by an accelerated stability study. Therefore, the C. acaulis EO and C. acaulis-based NE were evaluated for their toxicity against 1st instar larvae of the European grapevine moth (EGVM), Lobesia botrana (Denis & Schiffermüller, 1775) (Lepidoptera: Tortricidae), a major vineyard pest. The chemical composition of C. acaulis EO was investigated by gas chromatography–mass spectrometry (GC–MS) revealing carlina oxide, a polyacetylene, as the main constituent. In toxicity assays, both the C. acaulis EO and the C. acaulis-based NE were highly toxic to L. botrana larvae, with LC50 values of 7.299 and 9.044 µL/mL for C. acaulis EO and NE, respectively. The C. acaulis-based NE represents a promising option to develop highly stable botanical insecticides for pest management. To date, this study represents the first evidence about the insecticidal toxicity of EOs and EO-based NEs against this major grapevine pest.

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Section: Methodsmentioning

confidence: 99%

Developing a Highly Stable Carlina acaulis Essential Oil Nanoemulsion for Managing Lobesia botrana

et al. 2020

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“…Upon conducting the in vitro and in vivo experimentation, good results were obtained, indicating a great potential for Carvedilol NE to be used in the future [156]. In another study, a significant increase in the Carvedilol permeability coefficient in the NE vehicle was obtained, compared to control film [157].…”

Section: Transdermal O/w Nes Containing Hydrophobic Drugsmentioning

confidence: 99%

“…Such results were mainly attributed to the optimum droplet size and low viscosity. [156,157] Meloxicam Caprylic acid Tween 80 PEG 400 -Water…”

Section: Peg -Watermentioning

confidence: 99%

Nanoemulsion: A Review on Mechanisms for the Transdermal Delivery of Hydrophobic and Hydrophilic Drugs

et al. 2019

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Nanoemulsions (NEs) are colloidal dispersions of two immiscible liquids, oil and water, in which one is dispersed in the other with the aid of a surfactant/co-surfactant mixture, either forming oil-in-water (o/w) or water-in-oil (w/o) nanodroplets systems, with droplets 20–200 nm in size. NEs are easy to prepare and upscale, and they show high variability in their components. They have proven to be very viable, non-invasive, and cost-effective nanocarriers for the enhanced transdermal delivery of a wide range of active compounds that tend to metabolize heavily or suffer from undesirable side effects when taken orally. In addition, the anti-microbial and anti-viral properties of NE components, leading to preservative-free formulations, make NE a very attractive approach for transdermal drug delivery. This review focuses on how NEs mechanistically deliver both lipophilic and hydrophilic drugs through skin layers to reach the blood stream, exerting the desired therapeutic effect. It highlights the mechanisms and strategies executed to effectively deliver drugs, both with o/w and w/o NE types, through the transdermal way. However, the mechanisms reported in the literature are highly diverse, to the extent that a definite mechanism is not conclusive.

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“…It has already been demonstrated that nanoencapsulation of lipophilic molecules can increase their concentration in a gel while keeping its pH, rheological or sensory properties unchanged [12,13]. Moreover, nanosystems have also been used to disperse homogeneously an active molecule in films for transdermal or dermal delivery [6,10,[14][15][16][17]. In the present study, a nanodispersion of Punica granatum seed oil hydroxyphenethyl ester (PHE) was prepared by an ultrasound-mediated emulsion-evaporation method.…”

Section: Introductionmentioning

confidence: 96%

“…Therefore, it is very difficult to include large amounts of lipid-based active ingredients in these hydrophilic polymers. To address the issue of solubility, current strategy is to add to the preparation some water-miscible organic solvent, most commonly ethanol [9] or isopropanol [6,10]. However, the organic solvents do not ensure a homogeneous distribution of the active molecules within the resulting film [11] although they can affect the skin integrity.…”

Section: Introductionmentioning

confidence: 99%

Homogeneous distribution of fatty ester‐based active cosmetic ingredients in hydrophilic thin films by means of nanodispersion

Munnier

Assaad

David

et al. 2020

Intern J of Cosmetic Sci

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Objective Cosmetic films and patches are interesting forms to promote skin penetration of active ingredients as they ensure their long stay on the treated zone of the skin. Nevertheless, currently developed films and patches are most of all hydrophilic and are not adapted to the hydrophobic molecules. The aim of this study was to establish whether nanodispersion of fatty acid‐based active cosmetic ingredients (ACI) could be a manner to introduce high concentrations of those ACI in hydrophilic films. Methods Punica granatum seed oil hydroxyphenethyl esters (PHE) constitute a commercialized lipolytic cosmetic ingredient obtained by enzymatic conjugation of tyrosol to long‐chain fatty acids and to enhance its skin diffusion. Nanodispersions of PHE were prepared by a green emulsion‐solvent evaporation process and dispersed in polyvinyl alcohol films. Raman imaging coupled to multivariate analysis was used to study the distribution of PHE in the films. Results Nanodispersions of PHE combined with antioxidant vitamin E and stabilized by Pluronic® F127 were successfully prepared. The nanodispersions show a spherical shape and a hydrodynamic diameter close to 100 nm. Raman images analysis with multivariate approaches showed a very homogeneous distribution of PHE nanodispersions in the films compared to free PHE introduced as an ethanol solution. Conclusion Nanodispersions of hydrophobic fatty acid‐based ingredients seem to be relevant method to introduce this type of ingredient in hydrophilic film matrix. The co‐suspension with vitamin E limits their degradation in time.

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Nanoemulsion-based film formulation for transdermal delivery of carvedilol

Cited by 41 publications

References 36 publications

Developing a Highly Stable Carlina acaulis Essential Oil Nanoemulsion for Managing Lobesia botrana

Developing a Highly Stable Carlina acaulis Essential Oil Nanoemulsion for Managing Lobesia botrana

Nanoemulsion: A Review on Mechanisms for the Transdermal Delivery of Hydrophobic and Hydrophilic Drugs

Homogeneous distribution of fatty ester‐based active cosmetic ingredients in hydrophilic thin films by means of nanodispersion

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