Nanoemulsion Based Vehicle for Effective Ocular Delivery of Moxifloxacin Using Experimental Design and Pharmacokinetic Study in Rabbits

Shah, Jigar; Nair, Anroop B.; Jacob, Shery; Patel, Rakesh; Shah, Hiral; Shehata, Tamer M.; Morsy, Mohamed A.

doi:10.3390/pharmaceutics11050230

Cited by 105 publications

(67 citation statements)

References 32 publications

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“…Analysis of variance (ANOVA) was used for the statistical analysis. Interaction between the independent variables was evaluated from the generated perturbation plots, contour plots and 3D surface plots [ 30 ]. The software generated quadratic Equation (1) is represented below: Y = b0 + b1 × A + b2 × B + b3 × C + b12 × AB + b13 × AC + b23 × BC + b11 × A2 + b22 × B2 + b33 × C2 where measured response is represented by Y, b0 is the intercept and the regression coefficients are represented by b0 to b3 for the model term of A, B and C, respectively.…”

Section: Methodsmentioning

confidence: 99%

Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy in Wound Healing

et al. 2020

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The potential role of naringenin (NAR), a natural flavonoid, in the treatment of chronic wound has prompted the present research to deliver the drug in nanoemulsion (NE) form, where synergistic role of chitosan was achieved through development of chitosan-coated NAR NE (CNNE). The NE consisted of Capryol 90, Tween 20 and Transcutol P, which was fabricated by low-energy emulsification method to encapsulate NAR within the oil core. The optimization of the formulated NEs was performed using Box–Behnken statistical design to obtain crucial variable parameters that influence globule size, size distribution and surface charge. Finally, the optimized formulation was coated with different concentrations of chitosan and subsequently characterized in vitro. The size of the CNNE was found to be increased when the drug-loaded formulation was coated with chitosan. Controlled release characteristics depicted 67–81% release of NAR from the CNNE, compared to 89% from the NE formulation. Cytotoxicity study of the formulation was performed in vitro using fibroblast cell line (NIH-3T3), where no inhibition in proliferation of the cells was observed with CNNE. Finally, the wound healing potential of the CNNE was evaluated in an abrasion-created wound model in experimental animals where the animals were treated and compared histologically at 0 and 14 days. Significant improvement in construction of the abrasion wound was observed when the animals were treated with formulated CNNE, whereas stimulation of skin regeneration was depicted in the histological examination. Therefore, it could be summarized that the chitosan coating of the developed NAR NE is a potential platform to accelerate healing of wounds.

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Section: Methodsmentioning

confidence: 99%

Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy in Wound Healing

et al. 2020

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“…This proves the ability of the polymer to retain intact in both acidic and basic simulated fluid. Results of in vitro release studies were then fit with various kinetic models [34]. The most studied models are the Higuchi, first-order, Hixon-Crowell, Baker-Lonsdale, and Peppas, and the best fit with R 2 = 0.9972 was seen in the Peppas model, with release exponent value n = 0.72.…”

Section: Xrdmentioning

confidence: 99%

HPMC- and PLGA-Based Nanoparticles for the Mucoadhesive Delivery of Sitagliptin: Optimization and In Vivo Evaluation in Rats

et al. 2019

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Mucoadhesive nanoparticles represent a potential drug delivery strategy to enhance the therapeutic efficacy in oral therapy. This study assessed the prospective of developing HPMC- and PLGA-based nanoparticles using a nanospray drier as a mucoadhesive extended release drug delivery system for sitagliptin and evaluated their potential in an animal model. Nanoparticles were prepared using a Buchi® B-90 nanospray drier. Optimization of particle size was performed using response surface methodology by examining the influence of spray-drying process variables (inlet temperature, feed flow, and polymer concentration) on the particle size. The prepared nanoparticles were characterized for various physicochemical characteristics (yield, drug content, morphology, particle size, thermal, and crystallographic properties) and assessed for drug release, stability, and mucoadhesive efficacy by ex vivo and in vivo studies in rats. A linear model was suggested by the design of the experiments to be the best fit for the generated design and values. The yield was 77 ± 4%, and the drug content was 90.5 ± 3.5%. Prepared nanoparticles showed an average particle size of 448.8 nm, with a narrow particle size distribution, and were wrinkled. Thermal and crystallographic characteristics showed that the drug present in the nanoparticles is in amorphous dispersion. Nanoparticles exhibited a biphasic drug release with an initial rapid release (24.9 ± 2.7% at 30 min) and a prolonged release (98.9 ± 1.8% up to 12 h). The ex vivo mucoadhesive studies confirmed the adherence of nanoparticles in stomach mucosa for a long period. Histopathological assessment showed that the formulation is safe for oral drug delivery. Nanoparticles showed a significantly higher (p < 0.05) amount of sitagliptin retention in the GIT (gastrointestinal tract) as compared to control. The data observed in this study indicate that the prepared mucoadhesive nanoparticles can be an effective alternative delivery system for the oral therapy of sitagliptin.

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“…Moxifloxacin was included at a concentration of 0.5% w/w. Reproduced by Shah et al 78 TEM, transmission electron microscope.…”

Section: Novel Ocular Microemulsions 347mentioning

confidence: 99%

“…(average size = 28.78 -10.34) was further evaluated for ex vivo permeation, antimicrobial activity, ocular irritation, and stability, indicating its safety, great aqueous humor concentration, and antimicrobial properties. 78 Vancomycin (VM)-loaded MEs for ocular applications were studied by Nair et al For their preparation, oleic acid, ethyl oleate, linseed oil, olive oil, castor oil, and soybean oil were chosen as oil phases and span and Tween 80 as surfactants. It was found out that that MEs showed acceptable physicochemical behavior mostly for pH value, refractive index, and viscosity.…”

Section: Novel Ocular Microemulsionsmentioning

confidence: 99%

Novel Ocular Drug Delivery Systems: An Update on Microemulsions

Okur

Çağlar

Sıafaka

2020

Journal of Ocular Pharmacology and Therapeutics

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Sufficient ophthalmic drug delivery is still challenging for pharmaceutical technologists, despite various scientific efforts. Several ocular drug carriers have been designed to enhance bioavailability by prolonging the drug retention time. One of the current encouraging approaches is the utilization of colloidal carriers with the characteristic submicron-nanometer size. Microemulsions (MEs) are such colloid systems that present sizes between 5 and 200 nm with significant thermodynamic stability and low surface tension. In addition, MEs as topical ocular carriers can lead to great ocular drug adsorption due to their enhanced retention time. Furthermore, considering that MEs are stable for long time and various temperatures, their ocular application is of great interest. The aim of this study is to cover basic physicochemical principals of ocular MEs such as their possible size, stability, and therapeutic efficacy against various eye disorders. Thus, a comprehensive review for ocular drug delivery systems in the form of MEs that show promising characteristics as their stability and therapeutic efficiency is performed.

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Nanoemulsion Based Vehicle for Effective Ocular Delivery of Moxifloxacin Using Experimental Design and Pharmacokinetic Study in Rabbits

Cited by 105 publications

References 32 publications

Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy in Wound Healing

Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy in Wound Healing

HPMC- and PLGA-Based Nanoparticles for the Mucoadhesive Delivery of Sitagliptin: Optimization and In Vivo Evaluation in Rats

Novel Ocular Drug Delivery Systems: An Update on Microemulsions

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