Nanoemulsion Gel Formulation Optimization for Burn Wounds: Analysis of Rheological and Sensory Properties

Abstract

Background: Despite the variety of treatment methods for wounds and scars after burns, there are still few effective preparations that can be used in a non-invasive therapy. Recent years have seen significant development of nanomedicine and nanotechnology in the treatment of infection in burn wounds. Proposal: The aim of this work was to develop a formula of a nanoemulsion gel for skin regeneration after burns, and to compare its rheological and sensory properties, as well as the effectiveness of post-burn skin regeneration with preparations available on the market. Methods: At the first stage of studies the composition and parameters of the preparation of sea buckthorn oil-based O/W (oil-in-water) nanoemulsion containing hyaluronic acid and aloe vera gel, as the active ingredients were optimized. Then, the nanoemulsion was added to the gel matrix composed of carbomer (1%) and water which resulted in receiving nanoemulgel. The physicochemical parameters of the obtained samples were characterized by means of dynamic light scattering method and scanning electron microscope. Rheological, sensory and influence on skin condition analysis was conducted for selected market products and developed nanoemulgel. Results: Nanoemulsion gel (d = 211 ± 1.4 nm, polydispersity index (PDI) = 0.205 ± 0.01) was characterized by semi-solid, non-sticky consistency, porous structure, law viscosity, good “primary” and “secondary” skin feelings and pleasant sensorical properties. It improves the condition of burned skin by creating a protective layer on the skin and increasing the hydration level. Conclusion: Due to the fact that the obtained nanoemulsion gel combines the advantages of an emulsion and a gel formulation, it can be a promising alternative to medical cosmetics available on the market, as a form of formulation used in skin care after burns.

Thiolated Silicone Oils as New Components of Protective Creams in the Prevention of Skin Diseases

“…The consistency is also a feature that makes the products attractive to consumers. It is worth adding that it affects the effectiveness of the action of creams applied to the skin [ 46 , 49 ]. Due to their intended purpose, protective preparations used in wet environments contain hydrophobic compounds.…”

To compare the effect of sea buckthorn and silver sulfadiazine dressing on period of wound healing in patients with second‐degree burns: A randomized triple‐blind clinical trial

“…Consistent with the present study, Kaur and Kapoor 41 in their study stated that in addition to having antibacterial and antifungal properties, the compounds produced from sea buckthorn oil facilitate the wound healing process. The results of the research of Miastkowska et al 42 also showed that the gel made from sea buckthorn by forming a coating layer on the wound, keeping it moist, and also preventing the penetration of external factors into it, facilitates the wound healing process. Goudarzi et al 43 in their study reported that in addition to its anti‐inflammatory properties, sea buckthorn facilitates the wound healing process due to its analgesic and anti‐hypersensitivity effects, moreover.…”

Nanoemulsion delivery systems for enhanced efficacy of antimicrobials and essential oils

“…16,17 The o/w or w/o NE can be prepared as liquid (typically less than 20–30% fatty substances) or semi-solid such as creams that maintain the portion of the internal phase between 30–70%. 53 NE can also be prepared as a 3-dimensional network gel using a mucoadhesive polymer such as chitosan. 34 Antimicrobial creams and gel semi-solids can be applied topically to provide an effective means of delivery of the active ingredient directly on the surface of infected areas such as skin or certain mucous membranes.…”