Nanoengineered Drug Delivery Systems for Enhancing Antibiotic Therapy

Kalhapure, Rahul S.; Suleman, Nadia; Mocktar, Chunderika; Seedat, Nasreen; Govender, Thirumala

doi:10.1002/jps.24298

Cited by 176 publications

(112 citation statements)

References 315 publications

(461 reference statements)

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“…Very importantly, this type of carrier was also shown to facilitate the transport of the drug through cellular and tissue barriers. An excellent recent review about this topic can be found in the literature, where the relevant works in the field, along with their main findings are presented [175,180,181]. In a very recent and interesting contribution, Li et al [13] prepared polymer vesicles from poly(ethylene glycol) (PEG) and hydrophobic blocks containing enzyme-cleavable self-immolative side linkages.…”

Section: Biocide-releasing Polymersmentioning

confidence: 99%

“…Dendritic structures have also proven useful in the delivery of antibiotics as described in the recent review by Kalhapure et al [181]. In recent years, although less explored than the strategies presented above, antibiotic delivery systems based on hydrogels [182,183,184] and nanofibers or nanofibrous mats [160,185,186,187] have been also used.…”

Section: Biocide-releasing Polymersmentioning

confidence: 99%

See 1 more Smart Citation

Recent Developments in Antimicrobial Polymers: A Review

et al. 2016

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Antimicrobial polymers represent a very promising class of therapeutics with unique characteristics for fighting microbial infections. As the classic antibiotics exhibit an increasingly low capacity to effectively act on microorganisms, new solutions must be developed. The importance of this class of materials emerged from the uncontrolled use of antibiotics, which led to the advent of multidrug-resistant microbes, being nowadays one of the most serious public health problems. This review presents a critical discussion of the latest developments involving the use of different classes of antimicrobial polymers. The synthesis pathways used to afford macromolecules with antimicrobial properties, as well as the relationship between the structure and performance of these materials are discussed.

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Section: Biocide-releasing Polymersmentioning

confidence: 99%

Section: Biocide-releasing Polymersmentioning

confidence: 99%

Recent Developments in Antimicrobial Polymers: A Review

et al. 2016

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“…Nanostructured drug delivery carriers are known for their ability to enhance the antibiotic therapies 50 and their role is expected to be especially prominent against intracellular pathogens 51 . Vancomycin-loaded composite pastes were effective in reducing the concentration of all five types of bacteria analyzed in this study: S. aureus, S. enteritidis, S. liquefaciens, P. aeruginosa, and E.coli .…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial hydroxyapatite–gelatin–silica composite pastes with tunable setting properties

Uskoković

Ghosh

2017

J. Mater. Chem. B

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Bone grafting is one of the commonest surgical procedures, yet all bone substitutes developed so far suffer from specific weaknesses and the search for a bone graft material with ideal physical and biological properties is still ongoing. Calcium phosphate pastes are the most frequently used synthetic bone grafts, yet they (a) often take an impractically long time to set, (b) release the drug content too fast, and (c) do not form pores large enough to accommodate host cells and foster osseointegration. To make up for these deficiencies, we introduced gelatin and silica to pastes composed of 5–15 nm sized hydroxyapatite nanoparticles and yielded a bioresorbable composite that is compact, yet flowing upon injection; that prevents setting at room temperature, but sets promptly, in minutes, at 37 °C; that displays an increase in surface porosity following immersion in physiological fluids; that allows for sustained release of antibiotics; and that sets in a tunable manner and in clinically relevant time windows: 1–3 minutes at its fastest. Timelapse, in situ X-ray diffraction analysis demonstrated that the setting process is accompanied by an increase in crystallinity of the initially amorphous hydroxyapatite, involving no polymorphic phase transitions in its course. Setting time can be tuned by controlling the weight content of gelatin or powder-to-liquid ratio. The release of vancomycin was slow, ~ 8 % after 2 weeks, and unaffected by the gelatin content. While vancomycin-loaded pastes were effective in reducing the concentration of all bacterial species analyzed, the bacteriostatic effects of the antibiotic-free pastes were pronounced against S. liquefaciens and E. coli. S. liquefaciens bacilli underwent beading and filamentation during the treatment, suggesting that the antimicrobial effects are attributable to cell wall disruption by hydroxyapatite nanoparticles. Vancomycin-loaded pastes augmented the activity of the antibiotic against P. aeruginosa and S. liquefaciens, while exhibiting no negative effects against human mesenchymal stem cells. They were also uptaken three times more abundantly than pure hydroxyapatite, indicating the theoretical favorability of their use for intracellular delivery of therapeutics. This selectivity, toxic for bacteria and harmless for primary stem cells, is promising for application as bone grafts for osteomyelitis.

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“…Nano drug delivery systems are an outstanding strategy for ameliorating and solving many drug‐related problems (Ammar, Badawi, Mostafa, & Abou‐Taleb, ; El‐Ridy, Yehia, Mohsen, El‐Awdan, & Darwish, ). Nanosponges have been used to overcome the main dilemma of the microbial resistance to certain drugs, and likewise causing a noticeable improvement of both the pharmacodynamics and pharmacokinetic characteristics of drugs with antibacterial effectiveness (Forier et al, ; Kalhapure, Suleman, Mocktar, Seedat, & Govender, ). Nanosponges are small mesh‐like assemblies with a nanosize scaffold structure.…”

Section: Introductionmentioning

confidence: 99%

Investigation of a new horizon antifungal activity with enhancing the antimicrobial efficacy of ciprofloxacin and its binary mixture via their encapsulation in nanoassemblies: in vitro and in vivo evaluation

Taleb

Darwish

Abood

et al. 2019

Drug Development Research

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The main goal of this study was to prepare and evaluate nanosponges containing ciprofloxacin (CIP) or its binary mixture with N-acetyl carnosine (NAC). Nanosponges were prepared by ultrasound-assisted synthesis technique using hydroxypropyl βetacyclodextrin (HPβ-CD), as the polymer and diphenyl carbonate (DPC) as the crosslinker. Entrapment efficiency (EE%) of CIP or its binary mixture with NAC in nanosponges was deduced spectrophotometrically. Nanosponges were characterized using several methods. EE% of CIP or its binary mixture with NAC inside nanosponges ranged from 98.63 ± 3.1 to 100 ± 0.07%. Particle size of nanosponges ranged from 66.7 to 90.1 nm. Release of drugs from nanosponges was biphasic and the release pattern followed Korsmeyer-Peppas model. Ex vivo and in vivo studies results showed that the antibacterial effect was enhanced with encapsulation of drugs in the nanosponge system. Furthermore, a potent antifungal activity was obtained from all examined formulae against Candida albicans (10231). The study revealed that successful encapsulation of CIP or its binary mixture with NAC in nanosponge formulations has innovated a new promising therapeutic activity for both drugs. K E Y W O R D S antibacterial efficacy, antifungal activity, ciprofloxacin, N-acetyl carnosine, nanosponge, ocular

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Nanoengineered Drug Delivery Systems for Enhancing Antibiotic Therapy

Cited by 176 publications

References 315 publications

Recent Developments in Antimicrobial Polymers: A Review

Recent Developments in Antimicrobial Polymers: A Review

Antimicrobial hydroxyapatite–gelatin–silica composite pastes with tunable setting properties

Investigation of a new horizon antifungal activity with enhancing the antimicrobial efficacy of ciprofloxacin and its binary mixture via their encapsulation in nanoassemblies: in vitro and in vivo evaluation

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