Nanoenzyme–chitosan hydrogel complex with cascade catalytic and self-reinforced antibacterial performance for accelerated healing of diabetic wounds

Abstract

The significant disability and fatality rate of diabetes chronic wounds necessitates the development of efficient diabetic wound healing techniques. Present oxygen treatment for wound healing is restricted by issues such...

Recent Advances in Nanozyme‐Based Materials for Inflammatory Bowel Disease

“…Different from SOD, CAT-like nanomaterials exert the function of ROS reliving through change of H 2 O 2 into O 2 which is beneficial to cell proliferation and can also be used to mitigate inflammation. [59,61,62] In the study constructed by Chen et al [43] Mn-MOF played CAT mimetic roles due to Mn 3+ in the transition state (Figure 2b). More importantly, this ion strategy not only inherit the admirable properties of MOF, such as large internal surface and adjustability, [63][64][65] but also provided effective encapsulation in dietary-fiber shells, making the Mn-MOF with CAT-like activity which shields the contents from gastric juice for effective operation in the intestine.…”

Advances in Gas Therapeutics for Wound Healing: Mechanisms, Delivery Materials, and Prospects

“…[ 83 ] However, both HBOT and TOT cannot achieve significant and effective wound healing because of their low O 2 solubility, poor tissue permeability, and difficulty in maintaining effective O 2 concentrations. [ 46 ]…”

“…However, gas therapy (GT) applied alone is usually limited by its low tissue permeability, poor solubility, and bioavailability. [ 46,47 ] Thus, as an emerging therapeutic strategy, gas therapeutic material platforms were introduced into tissue engineering in the last decade, offering a tremendous opportunity for significantly improving the efficacy of GT. Nanoparticles can achieve controlled release of gas through external stimulation such as magnetic/electric fields, X‐rays, and UV/near‐infrared (NIR) light.…”

“…[4] These molecules not only play a role in physiopathological processes but are also crucial in wound repair, performing various functions such as antimicrobial (NO, [5][6][7] H 2 S, [8,9] CO, [10][11][12][13][14][15][16] SO 2 , [17][18][19] and plasma), [20][21][22] anti-inflammatory (NO, [23] H 2 S, [24][25][26] CO, [27] SO 2 , [28] and H 2 ), [29,30] immunomodulatory (O 2 , [31] CO, [27] NO, [32] and H 2 S), [33] provascular (O 2 , [34][35][36][37][38] NO, [39] H 2 S, [40] CO, [41] and CO), 2 [42] extracellular matrix (ECM) formation, and remodeling (O 2 [37,[43][44][45] and NO).[39] However, gas therapy (GT) applied alone is usually limited by its low tissue permeability, poor solubility, and bioavailability. [46,47] Thus, as an emerging therapeutic strategy, gas...…”

“…[39] However, gas therapy (GT) applied alone is usually limited by its low tissue permeability, poor solubility, and bioavailability. [46,47] Thus, as an emerging therapeutic strategy, gas…”