Nanofiber-based scaffolds for tissue engineering

Ashammakhi, Nureddin; Ndreu, Albana; Yang, Ying; Ylikauppila, Hanna; Nikkola, L.

doi:10.1007/s00238-008-0217-3

Cited by 81 publications

(48 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Scaffolds suitable for tissue engineering should mimic the structural and biological function of native ECM as much as possible (Ma et al, 2005;Ashammakhi et al, 2008;Ma, 2004;Smith and Ma, 2004). Collagen is a major natural ECM component and has a fibrous structure with fibre bundles varying in diameter (50-500 nm) (Ma et al, 2005;Ashammakhi et al, 2008;Ma, 2004;Smith and Ma, 2004).…”

Section: Electrospun Conductive Polymers For Nerve Tissue Engineeringmentioning

confidence: 99%

“…Collagen is a major natural ECM component and has a fibrous structure with fibre bundles varying in diameter (50-500 nm) (Ma et al, 2005;Ashammakhi et al, 2008;Ma, 2004;Smith and Ma, 2004). Nanoscale dimensions have been shown by various researchers to influence cell behaviour.…”

Section: Electrospun Conductive Polymers For Nerve Tissue Engineeringmentioning

confidence: 99%

“…Nanoscale features have the potential to improve the specificity and accuracy of the materials for a number of neural engineering applications, ranging from neural probes to guidance channels for nerve regeneration (Seidlits et al, 2008). Nanofibrous scaffolds having fibres in the nanometer scale can therefore serve as a potential substrate for cell attachment, function and proliferation rather than the traditional scaffolds (Ma et al, 2005;Ashammakhi et al, 2008;Ma, 2004;Smith and Ma, 2004). Polymeric nanofibres can be processed by a number of techniques, such as drawing, template synthesis, phase separation, self-assembly and electrospinning (Ashammakhi et al, 2008;Smith and Ma, 2004).…”

Section: Electrospun Conductive Polymers For Nerve Tissue Engineeringmentioning

confidence: 99%

See 2 more Smart Citations

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

616

389

View full text Add to dashboard Cite

Among the numerous attempts to integrate tissue engineering concepts into strategies to repair nearly all parts of the body, neuronal repair stands out. This is partially due to the complexity of the nervous anatomical system, its functioning and the inefficiency of conventional repair approaches, which are based on single components of either biomaterials or cells alone. Electrical stimulation has been shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering. In this review, by taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, we discuss the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering. Other electrospun, composite, conductive scaffolds, such as PANI/gelatin and PPy/poly(ε-caprolactone), with or without electrical stimulation, are also discussed. Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed.

show abstract

Section: Electrospun Conductive Polymers For Nerve Tissue Engineeringmentioning

confidence: 99%

Section: Electrospun Conductive Polymers For Nerve Tissue Engineeringmentioning

confidence: 99%

Section: Electrospun Conductive Polymers For Nerve Tissue Engineeringmentioning

confidence: 99%

See 1 more Smart Citation

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

616

389

View full text Add to dashboard Cite

show abstract

“…have been used in biomedical applications. Biomaterials are used in dental implants, bone replacements, cartilages, heart valves, cosmetic surgeries, and vascular grafts [5,[13][14][15]. Electrospinning could be used to fabricate biocompatible thin film coating design and texture that can be deposited on implantable devices to facilitate the unification of these devices with the body.…”

Section: Medical Applications Of Nanofibersmentioning

confidence: 99%

Melt blown Polymeric Nanofibers for Medical Applications- An Overview

Bhat¹

2015

NSTOA

View full text Add to dashboard Cite

“…3 The three most important methods that can be used for the fabrication of nanofibers are phase separation, self-assembly, and electrospinning. 4 Phase separation can be used to obtain nanofibrous foams; however, it has many processing variables, such as the solvent, type of polymer, polymer concentration, and solvent exchange. Self-assembly has similar disadvantages, such as material limitations, and is a time-consuming process.…”

Section: Introductionmentioning

confidence: 99%

Effect of nanofiber content on bone regeneration of silk fibroin/poly(ε-caprolactone) nano/microfibrous composite scaffolds

Kim¹,

Park²,

Kim³

et al. 2015

IJN

View full text Add to dashboard Cite

The broad application of electrospun nanofibrous scaffolds in tissue engineering is limited by their small pore size, which has a negative influence on cell migration. This disadvantage could be significantly improved through the combination of nano- and microfibrous structure. To accomplish this, different nano/microfibrous scaffolds were produced by hybrid electrospinning, combining solution electrospinning with melt electrospinning, while varying the content of the nanofiber. The morphology of the silk fibroin (SF)/poly(ε-caprolactone) (PCL) nano/microfibrous composite scaffolds was investigated with field-emission scanning electron microscopy, while the mechanical and pore properties were assessed by measurement of tensile strength and mercury porosimetry. To assay cell proliferation, cell viability, and infiltration ability, human mesenchymal stem cells were seeded on the SF/PCL nano/microfibrous composite scaffolds. From in vivo tests, it was found that the bone-regenerating ability of SF/PCL nano/microfibrous composite scaffolds was closely associated with the nanofiber content in the composite scaffolds. In conclusion, this approach of controlling the nanofiber content in SF/PCL nano/microfibrous composite scaffolds could be useful in the design of novel scaffolds for tissue engineering.

show abstract

Nanofiber-based scaffolds for tissue engineering

Cited by 81 publications

References 103 publications

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Melt blown Polymeric Nanofibers for Medical Applications- An Overview

Effect of nanofiber content on bone regeneration of silk fibroin/poly(ε-caprolactone) nano/microfibrous composite scaffolds

Contact Info

Product

Resources

About

Nanofiber-based scaffolds for tissue engineering

Cited by 81 publications

References 103 publications

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Melt blown Polymeric Nanofibers for Medical Applications- An Overview

Effect of nanofiber content on bone regeneration of silk fibroin/poly(&epsilon;-caprolactone) nano/microfibrous composite scaffolds

Contact Info

Product

Resources

About

Effect of nanofiber content on bone regeneration of silk fibroin/poly(ε-caprolactone) nano/microfibrous composite scaffolds