Nanofiber Membrane for Chiral Detection of Tyrosine Enantiomer

Abstract

Chiral recognition has significant research value for understanding the specific bio-functions and capacity for exploiting the utility of each enantiomer. A homochiral membrane by incorporating metal-organic frameworks nanofibers into the chitosan matrix (MOF@CS) is synthesized. MOF@CS displays highly sensitive and quantitative detection of D/L-Tyr.L-Tyrosine (Tyr) and D-Tyr have different physiological activities. Both deficiency and excess of L-Tyr can put health at risk, while D-Tyr inhibits the nutritional balance in the body. Tyr enantiomer detection has significant research value for making clear the relation with diseases. In this work, we innovatively synthesized a homochiral membrane by incorporating metal-organic frameworks nanofibers into the chitosan matrix (MOF@CS). MOF@CS displays highly sensitive and quantitative detection of D/L-Tyr. The proposed chiral membrane could be considered for practical applications of Tyr related recognition.Chirality, taking the vastness of influence on different biochemical processes, is an essential property of asymmetric structures. [1] Chiral recognition has significant research value for knowing the specific bio-functions and capacity for exploiting the utility of each enantiomer. [2] Tyrosine (Tyr) as a non-essential amino acid, plays an important role in the life system. [3] Lack of L-Tyr can lead to depression and other psychological diseases, while excess may result in the generation of hereditary diseases. D-Tyr, as the enantiomer of L-Tyr, does not exist naturally, which inhibits the nutritional balance in the body. [4] Therefore, a faster and costeffective analytical approach of recognition and detection of Tyr enantiomers should be established.Electrochemical devices gradually common in chiral recognition due to the advantages of high sensitivity, good selectivity, convenient operation, and low price. [5] The majority of chiral

Enantioseparation Membranes: Research Status, Challenges, and Trends

“…At present, common chiral separation membranes can be divided into different types such as MMMs, carrier composite membranes, and molecularly imprinted membranes (MIM). [90][91][92][93] The preparation methods of chiral separation membranes mainly include precipitation phase transformation, interfacial polymerization, vacuum-assisted filtration, molecular imprinting, and electrostatic spinning. [94][95][96][97][98]…”