Nanoflare Couple: Multiplexed mRNA Imaging and Logic-Controlled Combinational Therapy

Yang, Yanjing; Tong, L.; He, Yao; Deng, Zhiwei; Li, Jiacheng; Liu, Hui; Nie, Jing; De, Wang; Huang, Jin; Zhong, Shian

doi:10.1021/acs.analchem.2c02689

Cited by 8 publications

(3 citation statements)

References 36 publications

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“…MicroRNAs (miRNAs) are short noncoding nucleic acid fragments, typically comprising 21–23 nucleotides, that play crucial roles in gene expression regulation and cellular functions [ 60 ]. MiRNAs can bind to target mRNA, leading to its inhibition or degradation, thereby regulating the expression levels of genes [ 61 ]. This regulatory mechanism has important functions in various biological processes, including maintaining cellular homeostasis, developmental regulation, cell proliferation, and apoptosis [ 62 , 63 , 64 ].…”

Section: Two-photon Excited Fna Probes For Biosensingmentioning

confidence: 99%

Functional Nucleic Acid Probes Based on Two-Photon for Biosensing

Wu,

Ma,

Wang

2023

Biosensors

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Functional nucleic acid (FNA) probes have been widely used in environmental monitoring, food analysis, clinical diagnosis, and biological imaging because of their easy synthesis, functional modification, flexible design, and stable properties. However, most FNA probes are designed based on one-photon (OP) in the ultraviolet or visible regions, and the effectiveness of these OP-based FNA probes may be hindered by certain factors, such as their potential for photodamage and limited light tissue penetration. Two-photon (TP) is characterized by the nonlinear absorption of two relatively low-energy photons of near-infrared (NIR) light with the resulting emission of high-energy ultraviolet or visible light. TP-based FNA probes have excellent properties, including lower tissue self-absorption and autofluorescence, reduced photodamage and photobleaching, and higher spatial resolution, making them more advantageous than the conventional OP-based FNA probes in biomedical sensing. In this review, we summarize the recent advances of TP-excited and -activated FNA probes and detail their applications in biomolecular detection. In addition, we also share our views on the highlights and limitations of TP-based FNA probes. The ultimate goal is to provide design approaches for the development of high-performance TP-based FNA probes, thereby promoting their biological applications.

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Section: Two-photon Excited Fna Probes For Biosensingmentioning

confidence: 99%

Functional Nucleic Acid Probes Based on Two-Photon for Biosensing

Wu,

Ma,

Wang

2023

Biosensors

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“…This NF has been successfully used for combined PTT. [ 97 ] To detect non‐nucleic acid biomarkers, aptamer modified NF have been developed. In 2009, the Mirkin group first introduced ATP aptamer‐modified SNA for ATP sensing and cell imaging.…”

Section: Dna Composites For In Vivo Imagingmentioning

confidence: 99%

DNA Composites and Applications in Bioanalysis

Fang

Zuo

2023

Advanced Sensor Research

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DNA combined with other functional nanomaterials plays crucial roles in biomedical areas, including bio‐detection, bioimaging, as well as disease diagnosis and treatment. Rapid advances in DNA composites for biological applications have been achieved during the past few decades. In this review, it is first summarized the synthesis methods of DNA composites with inorganic core and organic core, as well as the applications of DNA composites in cancer diagnosis. The in vitro detection of various disease biomarkers and in vivo tumor imaging using DNA composites are introduced. Finally, main challenges and the new frontiers in the field of using DNA composites for cancer diagnosis are summarized.

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“…[16][17][18] The SNAs of DNA-AuNP conjugates not only possess the unique optical properties of AuNPs and the flexible programmability of oligonucleotides, but also show new properties, such as high level cellular uptake by various cells without the use of transfection agents, increased DNA stability against enzymatic degradation, and low cytotoxicity to cells. These characteristics have made them ideal for nucleic acid detection, [19][20][21][22] biological imaging, 23,24 drug delivery, 25,26 and disease treatment, 27,28 among other applications. 14,29 However, the construction of traditional SNAs is based on the Au-S chemical bond, 30 and it is challenging to precise control the density and orientation of DNA on the surface of AuNPs, thus limiting the performance of target recognition.…”

Section: Introductionmentioning

confidence: 99%