Nanogold probe enhanced Surface Plasmon Resonance immunosensor for improved detection of antibiotic residues

Fernández, Fátima; Sánchez‐Baeza, Francisco; Marco, M.‐Pilar

doi:10.1016/j.bios.2012.01.036

Cited by 71 publications

(30 citation statements)

References 36 publications

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“…Generally, sandwich [76] and competitive or inhibition assay [77] are two major detection approaches in SPR biosensor. In 2012, Fernandez et al [78] demonstrated that AuNMs combined with sandwich assays could improve detection sensitivity and selectivity of protein detection. Jung et al [79] introduced a strategy for enhancement of SPR signals by adopting AuNPs and a SiO 2 layer on an Au surface.…”

Section: Biomoleculesmentioning

confidence: 99%

Advanced AuNMs as nanomedicine’s central goals capable of active targeting in both imaging and therapy in biomolecules

Lh¹

2017

Glob Drugs Therap

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Section: Biomoleculesmentioning

confidence: 99%

Advanced AuNMs as nanomedicine’s central goals capable of active targeting in both imaging and therapy in biomolecules

Lh¹

2017

Glob Drugs Therap

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“…AuNPs are one of the most widely-used nanomaterials in the fabrication of electrochemical immunosensor for their excellent physicochemical properties including good conductivity and biocompatibility [15,16]. They can provide more active sites for the binding of antibodies and can accelerate the electron transfer process for signal enhancement.…”

Section: Introductionmentioning

confidence: 99%

Sensitive electrochemical determination of α-fetoprotein using a glassy carbon electrode modified with in-situ grown gold nanoparticles, graphene oxide and MWCNTs acting as signal amplifiers

et al. 2015

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The authors describe an electrochemical immunoassay for α-fetoprotein (α-FP) using a glassy carbon electrode (GCE) modified with a nanocomposite made from gold nanoparticles, graphene oxide and multi-walled carbon nanotubes (AuNPs/GO-MWCNTs) and acting as a signal amplification matrix. The nanocomposite was synthesized in a one-pot redox reaction between GO and HAuCl 4 without using an additional reductant. The stepwise assembly of the immunoelectrode was characterized by means of cyclic voltammetry and electrochemical impedance spectroscopy. The interaction of antigen and antibody on the surface of the electrode creates a barrier for electrons and causes retarded electron transfer, this resulting in decreased signals in differential pulse voltammetry of hexacyanoferrate which is added as an electrochemical probe. Using this strategy and by working at a potential of 0.2 V (vs. SCE), a wide analytical range (0.01 -100 ng mL‾ 1 ) is covered. The correlation coefficient is 0.9929, and the limit of detection is as low as 3 pg mL‾ 1 at a signal-to-noise ratio of 3. This electrochemical immunoassay combines the specificity of an immunological detection scheme with the sensitivity of an electrode modified with AuNPs and GO-MWCNTs.

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“…81 Generally, sandwich 82 and competitive or inhibition assay 83 are two major detection approaches in SPR biosensor. In 2012, Fernandez et al 84 demonstrated that AuNMs combined with sandwich assays could improve detection sensitivity and selectivity of protein detection. 84 Jung et al 85 introduced a strategy for enhancement of SPR signals by adopting AuNPs and a SiO 2 layer on a Au surface.…”

Section: Biomolecules (Dna Protein and Cell)mentioning

confidence: 99%

“…In 2012, Fernandez et al 84 demonstrated that AuNMs combined with sandwich assays could improve detection sensitivity and selectivity of protein detection. 84 Jung et al 85 introduced a strategy for enhancement of SPR signals by adopting AuNPs and a SiO 2 layer on a Au surface. The modified surfaces showed significant changes in SPR signal when biomolecules were attached to the surface as compared with an unmodified Au surface.…”

Section: Biomolecules (Dna Protein and Cell)mentioning

confidence: 99%

Applications of gold nanoparticles in medicine and therapy

Madkour¹

2018

PPIJ

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The stability and dispersity of AuNMs in solution play a key role for the many applications. Most inorganic nanomaterials are not well dispersed in physiological buffers and require function-alization by thiols or surfactants to offer the stabilization forces. Furthermore, sufficient blood circulation time is critical for both imaging and in vivo drug delivery. Localized surface Plasmon resonance (LSPR) is one of the most significant features of AuNMs. The AuNMs as reporters have been broadly applied into lateral flow immunechromatographicalassay (LFICA) and enzyme-linked immunosorbent assay (ELISA), which is a well-established technology for analysis of the target analytes in food safety, clinical diagnosis, environmental monitoring, and medical science and so on. Au based nanomaterials (AuNMs) are known to possess many attractive features such as unique electrical, optical and catalytic properties as well as excellent biocompatibility. In this review, we summarize the current advancement on application of AuNMs in analytical sciences based on their local surface plasmon resonance, fluorescence and electrochemistry properties. AuNMs based imaging and therapy in biomolecules is explained. As one of the most reliable imaging modes, computed tomography (CT), X-ray and SERS imaging has been widely used owing to its high spatial and density resolution. We end the review by a discussion of the conjugation between gold nanoparticles with other kinds of nanoparticles such as other metals and carbon nano structures. Finally, future development in this research area is also prospected.

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Nanogold probe enhanced Surface Plasmon Resonance immunosensor for improved detection of antibiotic residues

Cited by 71 publications

References 36 publications

Advanced AuNMs as nanomedicine’s central goals capable of active targeting in both imaging and therapy in biomolecules

Advanced AuNMs as nanomedicine’s central goals capable of active targeting in both imaging and therapy in biomolecules

Sensitive electrochemical determination of α-fetoprotein using a glassy carbon electrode modified with in-situ grown gold nanoparticles, graphene oxide and MWCNTs acting as signal amplifiers

Applications of gold nanoparticles in medicine and therapy

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