Nanoliposomes containing three essential oils from the Artemisia genus as effective larvicides against Aedes aegypti and Anopheles stephensi

Sanei-Dehkordi, Alireza; Ghasemian, Abdolmajid; Zarenezhad, Elham; Qasemi, Hajar; Nasiri, Mahdi; Osanloo, Mahmoud

doi:10.1038/s41598-023-38284-6

Cited by 6 publications

(3 citation statements)

References 57 publications

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“…ATR-FTIR analysis was used to confirm the successful loading of the E. cardamomum EO in nanoliposomes. ATR-FTIR analysis can detect the characteristic absorption bands of the EO in the nanoliposomes, which indicates that the EO has been successfully incorporated into the nanoliposome structure ( 37 ). Interestingly, the obtained LC 50 in the current study was comparable with previous findings.…”

Section: Discussionmentioning

confidence: 99%

Comparative Effects of Elettaria cardamomum Essential Oil and Its Nanoliposomal State on Mortality of Anopheles stephensi Larvae

Djaefar Moemenbellah-Fard,

Hosseinizadeh,

Alipour

et al. 2024

JAD

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Background: Malaria has remained the most dreadful vector-borne disease; hence, vector control is the most affordable and achievable approach to mitigate the disease burden. Due to the emergence of resistance and environmental pollution, herbal larvicides are considered an alternative to chemical types. Also, nanotechnology has been proposed as a promising solution to improve the efficiency of plant larvicides. This study aimed to develop an effective herbal larvicide. Methods: The chemical composition of Elettaria cardamomum essential oil (EO) was first investigated. Nanoliposomes containing the EO were then prepared using the ethanol injection method. After that, the larvicidal efficacy of the EO and its liposomal state were compared against Anopheles stephensi in laboratory conditions. Results: Alpha-terpinyl acetate (77.59%), eucalyptol (4.38%), nerolidol (2.96%), linalool (1.77%), and limonene (1.69%) were the five major compounds of the EO. Nanoliposomes containing the EO with a particle size of 73±5 nm and a zeta potential of -16.3±0.8 mV were prepared. Additionally, the ATR-FTIR analysis verified the successful loading of the EO into nanoliposomes. The larvicidal activity of nanoliposomes exhibited remarkable potency, with an LC50 value of 14.35 (10–18) µg/mL, significantly more potent than the non-formulated EO, which had an LC50 value of 33.47 (28–39) µg/mL against Anopheles stephensi larvae. Conclusion: The nanoliposomes containing E. cardamomum EO showed promising efficacy against An. stephensi larvae. It could thus be considered for further application against other species of mosquitoes.

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Section: Discussionmentioning

confidence: 99%

Comparative Effects of Elettaria cardamomum Essential Oil and Its Nanoliposomal State on Mortality of Anopheles stephensi Larvae

Djaefar Moemenbellah-Fard,

Hosseinizadeh,

Alipour

et al. 2024

JAD

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“…Nanoliposomes containing A. dracunculus essential oil showed more significant larvicidal effect against A. stephensi when compared to other Artemisia species, such as A. annua and A. sieberi, even though all three presented toxic effects to larvae. A. dracunculus essential oil nanoliposomes caused 100% mortality at 50, 100 and 200 μg/mL, while A. annua reached this rate only at 200 μg/mL, and A. sieberi caused 77% [ 156 ]. On the other hand, Acroptilon repens essential oil nanoemulsion showed low larvicidal activity against A. stephensi because LC50 and LC90 values were 7 and 35 ppm, respectively [ 157 ].…”

Section: Antimalarial Effects Of Green Npsmentioning

confidence: 99%

Tiny Green Army: Fighting Malaria with Plants and Nanotechnology

Moraes-de-Souza,

de Moraes,

Silva

et al. 2024

Pharmaceutics

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Malaria poses a global threat to human health, with millions of cases and thousands of deaths each year, mainly affecting developing countries in tropical and subtropical regions. Malaria’s causative agent is Plasmodium species, generally transmitted in the hematophagous act of female Anopheles sp. mosquitoes. The main approaches to fighting malaria are eliminating the parasite through drug treatments and preventing transmission with vector control. However, vector and parasite resistance to current strategies set a challenge. In response to the loss of drug efficacy and the environmental impact of pesticides, the focus shifted to the search for biocompatible products that could be antimalarial. Plant derivatives have a millennial application in traditional medicine, including the treatment of malaria, and show toxic effects towards the parasite and the mosquito, aside from being accessible and affordable. Its disadvantage lies in the type of administration because green chemical compounds rapidly degrade. The nanoformulation of these compounds can improve bioavailability, solubility, and efficacy. Thus, the nanotechnology-based development of plant products represents a relevant tool in the fight against malaria. We aim to review the effects of nanoparticles synthesized with plant extracts on Anopheles and Plasmodium while outlining the nanotechnology green synthesis and current malaria prevention strategies.

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“…Due to their pharmacokinetic and pharmacodynamic properties, they are involved in treating various diseases from cancer to inflammatory diseases [17]. The liposome comprises an aqueous compartment surrounded by one or more lipid bilayers [18]. They protect the drug from degradation, reduce drug-related nonspecific toxicity, and can be produced and formulated easily for target-specific delivery [19].…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Role of Nano-Formulated Red Algae Extract in Cancer Management

Janani,

Girigoswami,

Deepika

et al. 2024

Molecules

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Cancer is one of the major causes of death, and its negative impact continues to rise globally. Chemotherapy, which is the most common therapy, has several limitations due to its tremendous side effects. Therefore, developing an alternate therapeutic agent with high biocompatibility is indeed needed. The anti-oxidative effects and bioactivities of several different crude extracts of marine algae have been evaluated both in vitro and in vivo. In the present study, we synthesized the aqueous extract (HA) from the marine algae Amphiroa anceps, and then, a liposome was formulated for that extract (NHA). The extracts were characterized using different photophysical tools like dynamic light scattering, UV–visible spectroscopy, FTIR, scanning electron microscopy, and GC-MS analysis. The SEM image revealed a size range of 112–185 nm for NHA and the GC-MS results showed the presence of octadecanoic acid and n-Hexadecanoic acid in the majority. The anticancer activity was studied using A549 cells, and the NHA inhibited the cancer cells dose-dependently, with the highest killing of 92% at 100 μg/mL. The in vivo studies in the zebrafish model showed that neither the HA nor NHA of Amphiroa anceps showed any teratogenic effect. The outcome of our study showed that NHA can be a potential drug candidate for inhibiting cancer with good biocompatibility up to a dose of 100 μg/mL.

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Nanoliposomes containing three essential oils from the Artemisia genus as effective larvicides against Aedes aegypti and Anopheles stephensi

Cited by 6 publications

References 57 publications

Comparative Effects of Elettaria cardamomum Essential Oil and Its Nanoliposomal State on Mortality of Anopheles stephensi Larvae

Comparative Effects of Elettaria cardamomum Essential Oil and Its Nanoliposomal State on Mortality of Anopheles stephensi Larvae

Tiny Green Army: Fighting Malaria with Plants and Nanotechnology

Unveiling the Role of Nano-Formulated Red Algae Extract in Cancer Management

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