Nanomaterial-functionalized Cellulose: Design, Characterization and Analytical Applications

Kirk, Kevin A.; Othman, Ali; Andreescu, Silvana

doi:10.2116/analsci.34.19

Cited by 15 publications

(8 citation statements)

References 128 publications

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“…Cellulose, poly(1,4- D -glucose), is one of the most widespread natural renewable resources on Earth and represents a potential source of high-value products. Cellulose is abundant, can be produced inexpensively on a large scale from sustainable sources, is biocompatible and biodegradable, and can be modified for a variety of applications [ 3 ]. Nanocellulose is produced from cellulose by varying chemical and biological processes.…”

Section: Introductionmentioning

confidence: 99%

3D-Printable Nanocellulose-Based Functional Materials: Fundamentals and Applications

2021

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Nanomaterials obtained from sustainable and natural sources have seen tremendous growth in recent times due to increasing interest in utilizing readily and widely available resources. Nanocellulose materials extracted from renewable biomasses hold great promise for increasing the sustainability of conventional materials in various applications owing to their biocompatibility, mechanical properties, ease of functionalization, and high abundance. Nanocellulose can be used to reinforce mechanical strength, impart antimicrobial activity, provide lighter, biodegradable, and more robust materials for packaging, and produce photochromic and electrochromic devices. While the fabrication and properties of nanocellulose are generally well established, their implementation in novel products and applications requires surface modification, assembly, and manufacturability to enable rapid tooling and scalable production. Additive manufacturing techniques such as 3D printing can improve functionality and enhance the ability to customize products while reducing fabrication time and wastage of materials. This review article provides an overview of nanocellulose as a sustainable material, covering the different properties, preparation methods, printability and strategies to functionalize nanocellulose into 3D-printed constructs. The applications of 3D-printed nanocellulose composites in food, environmental, and energy devices are outlined, and an overview of challenges and opportunities is provided.

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Section: Introductionmentioning

confidence: 99%

3D-Printable Nanocellulose-Based Functional Materials: Fundamentals and Applications

2021

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“…More importantly, cellulose paper is a common biodegradable and biocompatible material [ 4 ], and all these features allow researchers to conduct new research and innovative applications, especially in the development of paper-based sensors with facile fabrication and operation strategies. As such, paper-based platforms can be applied in large areas such as nucleic acid detection, food quality control or clinical and environmental monitoring [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Designing Efficient Low-Cost Paper-Based Sensing Plasmonic Nanoplatforms

Susu

Campu

Craciun

et al. 2018

Sensors

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Paper-based platforms can be a promising choice as portable sensors due to their low-cost and facile fabrication, ease of use, high sensitivity, specificity and flexibility. By combining the qualities of these 3D platforms with the optical properties of gold nanoparticles, it is possible to create efficient nanodevices with desired biosensing functionalities. In this work, we propose a new plasmonic paper-based dual localized surface plasmon resonance–surface-enhanced Raman scattering (LSPR-SERS) nanoplatform with improved detection abilities in terms of high sensitivity, uniformity and reproducibility. Specifically, colloidal gold nanorods (GNRs) with a well-controlled plasmonic response were firstly synthesized and validated as efficient dual LSPR-SERS nanosensors in solution using the p-aminothiophenol (p-ATP) analyte. GNRs were then efficiently immobilized onto the paper via the immersion approach, thus obtaining plasmonic nanoplatforms with a modulated LSPR response. The successful deposition of the nanoparticles onto the cellulose fibers was confirmed by LSPR measurements, which demonstrate the preserved plasmonic response after immobilization, as well as by dark-field microscopy and scanning electron microscopy investigations, which confirm their uniform distribution. Finally, a limit of detection for p-ATP as low as 10−12 M has been achieved by our developed SERS-based paper nanoplatform, proving that our optimized plasmonic paper-based biosensing design could be further considered as an excellent candidate for miniaturized biomedical applications.

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“…[13][14][15][16] To address the diagnostics hurdles, and to enhance the sensitivity of the assay, nanoparticles-based immunoassays have been reported, which rely on the unique properties of nanoparticles and have improved detection limit up to 1000 times. [17][18][19][20]…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-based Point of Care Immunoassays for in vitro Biomedical Diagnostics

2018

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In resource-limited settings, the availability of medical practitioners and early diagnostic facilities are inadequate relative to the population size and disease burden. To address cost and delayed time issues in diagnostics, strip-based immunoassays, e.g. dipstick, lateral flow assay (LFA) and microfluidic paper-based analytical devices (microPADs), have emerged as promising alternatives to conventional diagnostic approaches. These assays rely on chromogenic agents to detect disease biomarkers. However, limited specificity and sensitivity have motivated scientists to improve the efficiency of these assays by conjugating chromogenic agents with nanoparticles for enhanced qualitative and quantitative output. Various nanomaterials, which include metallic, magnetic and luminescent nanoparticles, are being used in the fabrication of biosensors to detect and quantify biomolecules and disease biomarkers. This review discusses some of the principles and applications of such nanoparticle-based point of care biosensors in biomedical diagnosis.

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Nanomaterial-functionalized Cellulose: Design, Characterization and Analytical Applications

Cited by 15 publications

References 128 publications

3D-Printable Nanocellulose-Based Functional Materials: Fundamentals and Applications

3D-Printable Nanocellulose-Based Functional Materials: Fundamentals and Applications

Designing Efficient Low-Cost Paper-Based Sensing Plasmonic Nanoplatforms

Nanoparticle-based Point of Care Immunoassays for in vitro Biomedical Diagnostics

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