Nanomaterial-induced mesenchymal stem cell differentiation into osteoblast for counteracting bone resorption in the osteoporotic rats

Mahmoud, Nadia S.; Mohamed, Mohamed R.; Ali, Mohamed A.; Aglan, Hadeer A.; Amr, Khalda; Ahmed, Hanaa H.

doi:10.1016/j.tice.2021.101645

Cited by 6 publications

(4 citation statements)

References 46 publications

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“…Research conducted by Li et al 16 showed that nanoparticles can accelerate surrounding stem cells to differentiate into osteoblasts. Research conducted by Mahmoud et al 17 also proves that surface modification of titanium using nanotubes can increase and accelerate the differentiation of osteoblast cells. Furthermore, research conducted by Wu et al 18 found a significant osteoblast proliferation acceleration by using titanium nanomaterials.…”

Section: Discussionmentioning

confidence: 92%

The effect of nanoparticle tooth grafts on osteoblast stimulation in the first stages of the bone healing process in Wistar rats compared to the micro-tooth graft technique

Kumala,

Fauzia,

Junivianti

2023

Dent. J.

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Background: The use of a bone graft in bone regeneration is challenging. Tooth graft material has been used as a bone graft alternative due to its similar composition of organic and inorganic materials close to the bone. Recently, nanotechnology has been used to improve bone graft quality. The osteoconduction rate in the defect area represents the bone graft quality. Purpose: This study aimed to compare the number of osteoblasts using nano-tooth grafts and micro-tooth grafts in Wistar rats. Methods: Wistar rats were divided into six groups: the negative control groups (examined on days 7 and 14), the micro-tooth graft groups (examined on days 7 and 14), and the nano-tooth graft groups (examined on days 7 and 14). The control group received nothing, the micro-tooth group received a micro-size tooth graft, and the nano-tooth graft group received a nano-size tooth graft on the injured femur. Histological observations of osteoblasts were carried out using a light microscope with 1000x magnification. Data were analyzed using one-way analysis of variance and least significant difference tests. Results: On day 7, the nano-tooth graft group showed a higher osteoblast number (11.75) than the micro-tooth graft group (7.5) (p = 0.039). There was no significant difference in the micro-tooth graft group compared to the control (p > 0.05). On day 14, the nano-tooth graft group showed a decrease in osteoblast number close to normal (control) (p > 0.05), while the micro-tooth graft group still experienced significant elevation. Conclusion: Nano-tooth grafts accelerate the stimulation of osteoblasts in the first stages of the healing process compared to micro-tooth grafts.

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Section: Discussionmentioning

confidence: 92%

The effect of nanoparticle tooth grafts on osteoblast stimulation in the first stages of the bone healing process in Wistar rats compared to the micro-tooth graft technique

Kumala,

Fauzia,

Junivianti

2023

Dent. J.

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“…After adhesion and proliferation comes the differentiation of cells. MSCs are multiprogenitor cells that can be differentiated into the desired lineage of cells under conditions that stimulate the transition [144,145]. In the case of BTE, these progenitor cells are being used to treat bone defects by differentiating them into osteoblasts and affiliated cells that will aid in the regeneration process.…”

Section: Cell Differentiationmentioning

confidence: 99%

Recent Advancements in Electrospun Chitin and Chitosan Nanofibers for Bone Tissue Engineering Applications

Ganesh,

Anushikaa,

Swetha Victoria

et al. 2023

JFB

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Treatment of large segmental bone loss caused by fractures, osteomyelitis, and non-union results in expenses of around USD 300,000 per case. Moreover, the worst-case scenario results in amputation in 10% to 14.5% of cases. Biomaterials, cells, and regulatory elements are employed in bone tissue engineering (BTE) to create biosynthetic bone grafts with effective functionalization that can aid in the restoration of such fractured bones, preventing amputation and alleviating expenses. Chitin (CT) and chitosan (CS) are two of the most prevalent natural biopolymers utilized in the fields of biomaterials and BTE. To offer the structural and biochemical cues for augmenting bone formation, CT and CS can be employed alone or in combination with other biomaterials in the form of nanofibers (NFs). When compared with several fabrication methods available to produce scaffolds, electrospinning is regarded as superior since it enables the development of nanostructured scaffolds utilizing biopolymers. Electrospun nanofibers (ENFs) offer unique characteristics, including morphological resemblance to the extracellular matrix, high surface-area-to-volume ratio, permeability, porosity, and stability. This review elaborates on the recent strategies employed utilizing CT and CS ENFs and their biocomposites in BTE. We also summarize their implementation in supporting and delivering an osteogenic response to treat critical bone defects and their perspectives on rejuvenation. The CT- and CS-based ENF composite biomaterials show promise as potential constructions for bone tissue creation.

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“…When employed for bone regeneration operations, they have considerable surface, quantum, and size effects, which contribute to superior performance than standard materials. (10) The nano-crystalline hydroxyapatite (Nano-bone®) bone transplant is one of these materials. It's encased in a silica gel matrix that is permeable.…”

Section: Introductionmentioning

confidence: 99%

“…Rapid repair of critical-size defects was shown in animal trials and human applications because this substance attaches to bone and encourages bone healing by increasing osteoblastic activity. (10)(11)(12)(13) Although the relatively satisfactory results of the synthetic bone grafts, there are associated drawbacks and limitations to their use and availability, and even controversial reports about their efficacy and cost-effectiveness. Furthermore, there are no bone substitutes available that have superior or even the same biological properties compared with autogenous bone graft.…”

Section: Introductionmentioning

confidence: 99%

The effect of Nanocrystalline Hydroxyapatite -parathyroid hormone mixture on bone defect healing: Experimental Study in Dogs

Shokry

Ibrahim

Ismail

et al. 2022

Egyptian Dental Journal

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Objectives:The study aimed to evaluate the histological effect of nanocrystalline hydroxyapatite mixed with parathyroid hormone on the healing of mandibular bone defect. Material & Methods:The present study was conducted on 18 skeletally mature mongrel male dogs. The animals were randomly assigned (1:1) to one of the two groups (9 animals each) according to the treatment method: Study group where animal received PTH-Nanobone® mixture in a created osseous defects and control group where animal received Nanobone® solely within the defect. Three animals from each group were sacrificed at 3, 6 and 12 weeks postoperative. All groups were analyzed histological for the closure of the created osseous defect, the characteristics of the developed connective tissue, the nature of the formed osteoid matrix, the presence of acute or chronic inflammatory cells, and the type and progression of the healing process. Results:The histological examination showed significant difference between the 2 groups with better bone healing at Study group (PTH-Nanobone group). As the histological section Study group (PTH-Nanobone group) showed newly formed thin bone bridges of woven bone at 3 weeks postoperative while at 6weeks bone bridges of woven bone became thicker. At 12 weeks followup, both groups showed signs of healing although Study group (PTH-Nanobone group) had a more lamellar and well organized bone is formed with newly haversian systems with wide osteons become evident. Conclusion:The results suggest that nanocrystalline hydroxyapatite mixed with parathyroid hormone encouraged the bone healing in critical-size calvarial defects

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Nanomaterial-induced mesenchymal stem cell differentiation into osteoblast for counteracting bone resorption in the osteoporotic rats

Cited by 6 publications

References 46 publications

The effect of nanoparticle tooth grafts on osteoblast stimulation in the first stages of the bone healing process in Wistar rats compared to the micro-tooth graft technique

The effect of nanoparticle tooth grafts on osteoblast stimulation in the first stages of the bone healing process in Wistar rats compared to the micro-tooth graft technique

Recent Advancements in Electrospun Chitin and Chitosan Nanofibers for Bone Tissue Engineering Applications

The effect of Nanocrystalline Hydroxyapatite -parathyroid hormone mixture on bone defect healing: Experimental Study in Dogs

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