Nanomaterial-involved neural stem cell research: Disease treatment, cell labeling, and growth regulation

Liu, Xiangyu; Zhou, Chunxiao; Fang, Chao

doi:10.1016/j.biopha.2018.08.029

Cited by 9 publications

(1 citation statement)

References 191 publications

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“…Neuroregeneration through delivery of bioactive agents and stem cells has provided new opportunities for treating central and peripheral nervous systems related diseases (Liu et al, 2018). Local delivery and spatiotemporal control over the chemokine SDF-1 through various NP based delivery system has gained lots of attention as the SDF-1 can help recruitment and migration of neural stem cells (Dutta et al, 2017; Zamproni et al, 2017).…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Use of Nanoparticles in Tissue Engineering and Regenerative Medicine

Fathi‐Achachelouei

Knopf‐Marques

Silva

et al. 2019

Front. Bioeng. Biotechnol.

289

146

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Advances in nanoparticle (NP) production and demand for control over nanoscale systems have had significant impact on tissue engineering and regenerative medicine (TERM). NPs with low toxicity, contrasting agent properties, tailorable characteristics, targeted/stimuli-response delivery potential, and precise control over behavior (via external stimuli such as magnetic fields) have made it possible their use for improving engineered tissues and overcoming obstacles in TERM. Functional tissue and organ replacements require a high degree of spatial and temporal control over the biological events and also their real-time monitoring. Presentation and local delivery of bioactive (growth factors, chemokines, inhibitors, cytokines, genes etc.) and contrast agents in a controlled manner are important implements to exert control over and monitor the engineered tissues. This need resulted in utilization of NP based systems in tissue engineering scaffolds for delivery of multiple growth factors, for providing contrast for imaging and also for controlling properties of the scaffolds. Depending on the application, materials, as polymers, metals, ceramics and their different composites can be utilized for production of NPs. In this review, we will cover the use of NP systems in TERM and also provide an outlook for future potential use of such systems.

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Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Use of Nanoparticles in Tissue Engineering and Regenerative Medicine

Fathi‐Achachelouei

Knopf‐Marques

Silva

et al. 2019

Front. Bioeng. Biotechnol.

289

146

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Magnetic Nanobubble Mechanical Stress Induces the Piezo1‐Ca²⁺‐BMP2/Smad Pathway to Modulate Neural Stem Cell Fate and MRI/Ultrasound Dual Imaging Surveillance for Ischemic Stroke

Zhang

Lou

et al. 2022

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Neural stem cells (NSCs) are used to treat various nervous system diseases because of their self‐renewal ability and multidirectional differentiation potential. However, an insufficient ability to track their migration in vivo and poor control over their survival and differentiation efficiency are two major critical challenges for clinical application. Here, it is shown that when magnetic nanobubbles (MNBs), which are assembled from magnetic nanoparticles, are internalized by NSCs, intramembrane volumetric oscillation of the MNBs induces an increase in intracellular hydrostatic pressure and cytoskeleton force, resulting in the activation of the Piezo1‐Ca2+ mechanosensory channel. This subsequently triggers the BMP2/Smad biochemical signaling pathway, leading to differentiation of NSCs into the neuronal phenotype. Signaling through the Piezo1‐Ca2+‐BMP2/Smad pathway can be further accelerated by application of an external shear stress force using low‐intensity pulsed ultrasound. More importantly, magnetic resonance imaging and ultrasound imaging surveillance of NSCs based on MNB labeling can be leveraged to provide NSC therapeutic outcomes. Both the in vitro and in vivo findings demonstrate that a bubble nanostructure‐induced physical force can modulate and control the mechanical signaling pathway regulating stem cell development.

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Nanotechnology-based regenerative approaches

Roy,

Das,

Chakraborty

et al. 2023

Nanostructured Materials for Tissue Engineering

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Nanomaterial-involved neural stem cell research: Disease treatment, cell labeling, and growth regulation

Cited by 9 publications

References 191 publications

Use of Nanoparticles in Tissue Engineering and Regenerative Medicine

Use of Nanoparticles in Tissue Engineering and Regenerative Medicine

Magnetic Nanobubble Mechanical Stress Induces the Piezo1‐Ca²⁺‐BMP2/Smad Pathway to Modulate Neural Stem Cell Fate and MRI/Ultrasound Dual Imaging Surveillance for Ischemic Stroke

Nanotechnology-based regenerative approaches

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Nanomaterial-involved neural stem cell research: Disease treatment, cell labeling, and growth regulation

Cited by 9 publications

References 191 publications

Use of Nanoparticles in Tissue Engineering and Regenerative Medicine

Use of Nanoparticles in Tissue Engineering and Regenerative Medicine

Magnetic Nanobubble Mechanical Stress Induces the Piezo1‐Ca2+‐BMP2/Smad Pathway to Modulate Neural Stem Cell Fate and MRI/Ultrasound Dual Imaging Surveillance for Ischemic Stroke

Nanotechnology-based regenerative approaches

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Product

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Magnetic Nanobubble Mechanical Stress Induces the Piezo1‐Ca²⁺‐BMP2/Smad Pathway to Modulate Neural Stem Cell Fate and MRI/Ultrasound Dual Imaging Surveillance for Ischemic Stroke