Nanomaterials-based precision sonodynamic therapy enhancing immune checkpoint blockade: A promising strategy targeting solid tumor

Hypoxia-triggered degradable porphyrinic covalent organic framework for synergetic photodynamic and photothermal therapy of cancer

“…Thus, porphyrin-based COF could serve as promising candidates for biomedical application. Until now, many nano-size porphyrin-based COFs have been prepared and utilized in drug delivery [ 32 ], diagnosis [ 25 ], sonodynamic therapy (SDT) [ 33 , 34 ], PDT [ [35] , [36] , [37] ], PTT [ 38 , 39 ], and immunotherapy [ [40] , [41] , [42] ]. Nevertheless, Hypoxia-triggered and biodegradable porphyrin-based COFs have been little reported, and the unique performance has not been fully developed.…”