Nanomaterials for Modulating the Aggregation of β-Amyloid Peptides

Huang, Yaliang; Chang, Yong Keun; Liu, Lin; Wang, Jianxiu

doi:10.3390/molecules26144301

Cited by 25 publications

(11 citation statements)

References 201 publications

(275 reference statements)

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“…Alzheimer’s disease (AD) is the most common type of dementia. The underlying mechanism explaining the neurotoxicity induced by β-Amyloid peptide (Aβ) aggregates may be oxidative stress [ 17 , 18 ]. Therefore, the inhibition of Aβ fibril formation and the decomposition of Aβ aggregates are considered an important treatment strategy for AD.…”

Section: Neuroprotective Effects: Alzheimer’s Disease and Parkinson’s...mentioning

confidence: 99%

“…Gold nanoparticles have been reported by many researchers as having the function of penetrating through the BBB. In the past, many studies have proven that the physical properties of nanogold (AuNPs) have inhibited the aggregation of Aβ peptides and the degradation of Aβ aggregates [ 16 , 18 , 19 , 20 , 21 , 22 ]. AuNPs also showed inhibition of acetylcholinesterase and butyrylcholinesterase, contributing to an anti-Alzheimer’s disease effect [ 23 ].…”

Section: Neuroprotective Effects: Alzheimer’s Disease and Parkinson’s...mentioning

confidence: 99%

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Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

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Gold has always been regarded as a symbol of nobility, and its shiny golden appearance has always attracted the attention of many people. Gold has good ductility, molecular recognition properties, and good biocompatibility. At present, gold is being used in many fields. When gold particles are as small as several nanometers, their physical and chemical properties vary with their size in nanometers. The surface area of a nano-sized gold surface has a special effect. Therefore, gold nanoparticles can, directly and indirectly, give rise to different biological activities. For example, if the surface of the gold is sulfided. Various substances have a strong chemical reactivity and are easy to combine with sulfhydryl groups; hence, nanogold is often used in biomedical testing, disease diagnosis, and gene detection. Nanogold is easy to bind to proteins, such as antibodies, enzymes, or cytokines. In fact, scientists use nanogold to bind special antibodies, as a tool for targeting cancer cells. Gold nanoparticles are also directly cytotoxic to cancer cells. For diseases caused by inflammation and oxidative damage, gold nanoparticles also have antioxidant and anti-inflammatory effects. Based on these unique properties, gold nanoparticles have become the most widely studied metal nanomaterials. Many recent studies have further demonstrated that gold nanoparticles are beneficial for humans, due to their functional pharmacological properties in a variety of diseases. The content of this review will be the application of gold nanoparticles in treating or diagnosing pressing diseases, such as cancers, retinopathy, neurological diseases, skin disorders, bowel diseases, bone cartilage disorders, cardiovascular diseases, infections, and metabolic syndrome. Gold nanoparticles have shown very obvious therapeutic and application potential.

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Section: Neuroprotective Effects: Alzheimer’s Disease and Parkinson’s...mentioning

confidence: 99%

Section: Neuroprotective Effects: Alzheimer’s Disease and Parkinson’s...mentioning

confidence: 99%

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

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“…The most widely used metallic nanoparticle owing to few unique features like inert behaviour, local surface plasmon resonance absorption, tuneable structural and chemical properties is gold nanoparticle (AuNP) [ 51–59 ]. Bare AuNPs and AuNPs modified with peptides or other therapeutic molecules are majorly used for the treatment of AD and has shown anti-fibrillation property [ 54 ]. Bastus et al showed that a combination of heat and gold nanoparticles can dissolve the amyloid deposits locally and remotely [ 55 ].…”

Section: Nanotherapeutics: a Promising Tool For The Treatment Of Alzh...mentioning

confidence: 99%

Impact of nanoparticles on amyloid β-induced Alzheimer’s disease, tuberculosis, leprosy and cancer: a systematic review

et al. 2023

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Nanotechnology is an interdisciplinary domain of science, technology and engineering that deals with nano-sized materials/particles. Usually, the size of nanoparticles lies between 1-100 nm. Due to their small size and large surface area-to-volume ratio, nanoparticles exhibit high reactivity, greater stability and adsorption capacity. These important physicochemical properties attract scientific community to utilize them in biomedical field. Various types of nanoparticles (inorganic and organic) have broad applications in medical field ranging from imaging to gene therapy. These are also effective drug carriers. In recent times, nanoparticles are utilized to circumvent different treatment limitations. For example, the ability of nanoparticles to cross the blood brain barrier and having a certain degree of specificity towards amyloid deposits, makes themselves important candidates for the treatment of Alzheimer’s disease. Furthermore, nanotechnology has been used extensively to overcome several pertinent issues like drug-resistance phenomenon, side effects of conventional drugs and targeted drug delivery issue in leprosy, tuberculosis and cancer. Thus, in this review, the application of different nanoparticles for the treatment of these four important diseases (Alzheimer’s disease, tuberculosis, leprosy and cancer) as well as for the effective delivery of drugs used in these diseases has been presented systematically. Although nanoformulations have many advantages over traditional therapeutics for treating these diseases, nanotoxicity is a major concern which has been discussed subsequently. Lastly, we have presented the promising future prospective of nanoparticles as alternative therapeutics. In that section, we have discussed about the futuristic approach(es) that could provide promising candidate(s) for the treatment of these four diseases.

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“…Inhibition of protein aggregation was regarded as one of the potential therapy strategies toward protein aggregation diseases. [42,43] Unfortunately, CR only had weak inhibition effect on protein aggregation. [26] In contrast, CDs with the nano-size structure as well as plentiful surface functional groups commonly exerted some modulation effects on protein aggregation.…”

Section: Inhibition Of Protein Aggregation By Cdsmentioning

confidence: 99%

Congo Red‐Derived Carbon Dots: Simultaneously as Fluorescence Probe for Protein Aggregates, Inhibitor for Protein Aggregation, and Scavenger of Free Radicals

et al. 2023

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β-sheet-rich protein aggregates. [2] Protein aggregates deposit in the specific organ or tissue is possibly the significant hallmark of some protein aggregation diseases. [3] For example, the Lewy bodies contain abundant α-synuclein aggregates in the brain of PD patients, [3] and the extracellular senile plaques comprise both of Aβ 1-40 (Aβ 40 ) and Aβ 1-42 (Aβ 42 ) aggregates in the brain of AD patients. [3,4] Specifically, for the AD-associated proteins, Aβ 42 is a more prevalent amyloidogenic protein in the senile plaques, exhibiting faster aggregation rate in vitro and higher neurotoxicity in vivo than Aβ 40 , [4][5][6][7] which is a widely-accepted model aggregative protein in the AD study. [8] The formed protein aggregates, especially the soluble oligomers and protofibrils, could pose high cytotoxicity, causing the damage of cell membrane, dysfunction of organelles (such as mitochondrion and golgi apparatus) as well as cellular oxidative stress with elevated free radical level. [9][10][11][12] Therefore, detection of protein aggregates, inhibition of protein aggregation, and scavenging of free radical would be of great significance for the diagnosis and treatment of the protein aggregation diseases. [13,14] However, it is still challenging to achieve the dual purposes of simultaneous detection and treatment in one method. [15,16] Fluorescence imaging method with the characteristics of being low invasive and real time was widely developed for diagnosis. [13,17] As one of high-profile carbon-based nanomaterials, carbon dots (CDs), with the merits of excellent fluorescence property, good biocompatibility, low cytotoxicity, easy preparation, and low cost, [18,19] were introduced for fluorescence imaging of protein aggregates. [20][21][22][23] However, the fluorescence signals of some CDs were in the blue or green emission range, which were easily interfered by the autofluorescence of biological samples. [24] In contrast, red fluorescence response possessing good anti-interference ability was more preferable. [24] Besides, owing to the size effects and plentiful surface functional groups, CDs aroused researchers' interests in their potential inhibition effects on protein aggregation, which could be a strategy to delay or reverse the diseases. [16] Previously, Gao et al. proposed nitrogen-doped carbonized polymer dots, whichThe pathological aggregation of some proteins is claimed to be highly related to several human diseases, such as β-amyloid 1-42 (Aβ 42 ) to Alzheimer's disease (AD), islet amyloid polypeptide, and insulin to type 2 diabetes mellitus. Therefore, it is in desperate need to develop effective methods for detection of protein aggregates and inhibition of abnormal aggregation. Herein, to construct all-in-one probe with both diagnosis and treatment potentials for protein aggregation diseases, Congo red (CR), a classical staining reagent with red fluorescence signal output for protein aggregates, is deliberately adopted to react with three different reductive carbon sources and ammonium persulfate to ...

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Nanomaterials for Modulating the Aggregation of β-Amyloid Peptides

Cited by 25 publications

References 201 publications

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Impact of nanoparticles on amyloid β-induced Alzheimer’s disease, tuberculosis, leprosy and cancer: a systematic review

Congo Red‐Derived Carbon Dots: Simultaneously as Fluorescence Probe for Protein Aggregates, Inhibitor for Protein Aggregation, and Scavenger of Free Radicals

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