Nanomaterials for Skin Care

Miljković, Suzana; Tomić, Marija; Hut, Igor; Pelemiš, Svetlana

doi:10.1007/978-3-319-56979-6_9

Cited by 7 publications

(7 citation statements)

References 51 publications

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“…However, there exit some potential security risks for the use of nanomaterials. Toxic effects of nanoparticles (NPs) perniciously affect the normal structures of tissues or organs due to the size and shape of NPs [ 56 , 57 ]. According to the results of existing studies, there is no direct evidence to prove NPs are either harmful or harmless [ 57 ].…”

Section: Electrodes For Skin Impedance Measurementmentioning

confidence: 99%

“…Toxic effects of nanoparticles (NPs) perniciously affect the normal structures of tissues or organs due to the size and shape of NPs [ 56 , 57 ]. According to the results of existing studies, there is no direct evidence to prove NPs are either harmful or harmless [ 57 ]. However, the nanomaterial-based electrodes for SC impedance detection are non-invasively attached to the surface of the skin, which is supposed to have little influence on normal physiology.…”

Section: Electrodes For Skin Impedance Measurementmentioning

confidence: 99%

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Review of Stratum Corneum Impedance Measurement in Non-Invasive Penetration Application

Wang

Zhao

et al. 2018

Biosensors

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Due to advances in telemedicine, mobile medical care, wearable health monitoring, and electronic skin, great efforts have been directed to non-invasive monitoring and treatment of disease. These processes generally involve disease detection from interstitial fluid (ISF) instead of blood, and transdermal drug delivery. However, the quantitative extraction of ISF and the level of drug absorption are greatly affected by the individual’s skin permeability, which is closely related to the properties of the stratum corneum (SC). Therefore, measurement of SC impedance has been proposed as an appropriate way for assessing individual skin differences. In order to figure out the current status and research direction of human SC impedance detection, investigations regarding skin impedance measurement have been reviewed in this paper. Future directions are concluded after a review of impedance models, electrodes, measurement methods and systems, and their applications in treatment. It is believed that a well-matched skin impedance model and measurement method will be established for clinical and point-of care applications in the near future.

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Section: Electrodes For Skin Impedance Measurementmentioning

confidence: 99%

Section: Electrodes For Skin Impedance Measurementmentioning

confidence: 99%

Review of Stratum Corneum Impedance Measurement in Non-Invasive Penetration Application

Wang

Zhao

et al. 2018

Biosensors

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“…Nanoparticles are known to efficiently transport drugs into skin areas with HFs [38,39,40]. PGA/chitosan nanoparticles are capable of entrapping biomolecules or agents in internal structures [22,24] and have a small size for enhancing drug delivery to HFs. The space between the hair follicle (20–50 μm) and shaft (16–42 μm) is approximately 200–400 nm, into which nanoparticles can conveniently fit [41,42].…”

Section: Discussionmentioning

confidence: 99%

“…To increase the adsorption and transmission of hair-growth agents into the scalp, we applied a drug delivery technology that encapsulates hair-growth effective drugs or extracts into nanoparticles. Among them, PGA/chitosan nanoparticles are capable of entrapping biomolecules or agents into internal structures or absorbing them on their external surfaces [22,24]. They can also alter biological activities due to their large surface to volume ratio [22,24].…”

Section: Introductionmentioning

confidence: 99%

“…Among them, PGA/chitosan nanoparticles are capable of entrapping biomolecules or agents into internal structures or absorbing them on their external surfaces [22,24]. They can also alter biological activities due to their large surface to volume ratio [22,24]. In addition, topical application of γ-PGA can promote hair-growth by moving hair follicle (HF) states from the telogen to anagen phase [25].…”

Section: Introductionmentioning

confidence: 99%

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Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles (PGA-4HGF) by β-Catenin Activation and Its Related Cell Cycle Molecules

Lee

Kwon

Kim

et al. 2019

IJMS

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Poly-γ-glutamic acid (γ-PGA)-based nanoparticles draw remarkable attention as drug delivery agents due to their controlled release characteristics, low toxicity, and biocompatibility. 4HGF is an herbal mixture of Phellinus linteus grown on germinated brown rice, Cordyceps militaris grown on germinated soybeans, Polygonum multiflorum, Ficus carica, and Cocos nucifera oil. Here, we encapsulated 4HGF within PGA-based hydrogel nanoparticles, prepared by simple ionic gelation with chitosan, to facilitate its penetration into hair follicles (HFs). In this study, we report the hair promoting activity of 4HGF encapsulated with PGA nanoparticles (PGA-4HGF) and their mechanism, compared to 4HGF alone. The average size of spherical nanoparticles was ~400 nm in diameter. Continuous release of PGA-4HGF was observed in a simulated physiological condition. As expected, PGA-4HGF treatment increased hair length, induced earlier anagen initiation, and elongated the duration of the anagen phase in C57BL/6N mice, compared with free 4HGF treatment. PGA-4HGF significantly increased dermal papilla cell proliferation and induced cell cycle progression. PGA-4HGF also significantly increased the total amount of β-catenin protein expression, a stimulator of the anagen phase, through induction of cyclinD1 and CDK4 protein levels, compared to free 4HGF treatment. Our findings underscore the potential of PGA nanocapsules to efficiently deliver 4HGF into HFs, hence promoting hair-growth. Therefore, PGA-4HGF nanoparticles may be promising therapeutic agents for hair growth disorders.

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