Nanomaterials for small diameter vascular grafts: overview and outlook

Wang, Nuoxin; Wang, Haoyuan; Weng, Dong; Wang, Yanyang; Yu, Limei; Wang, Feng; Zhang, Tao; Liu, Juan; He, Zhixu

doi:10.1039/d3na00666b

Cited by 3 publications

(1 citation statement)

References 80 publications

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“…It can realize good control of material fibers and prepare ECM-like structures. ES substrates have been recognized as excellent materials for SDVGs ( Wang et al, 2023 ). As summarized above, the ES/SC blending SDVGs may combine the advantages from both sides, which may contribute to the address of the core challenges in SDVG field, such as lumen stenosis, intimal hyperplasia, and occlusion, providing a new idea for the construction of SDVGs with compelling functions.…”

Section: Discussionmentioning

confidence: 99%

Small diameter vascular grafts: progress on electrospinning matrix/stem cell blending approach

Wang,

Chen,

et al. 2024

Front. Bioeng. Biotechnol.

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The exploration of the next-generation small diameter vascular grafts (SDVGs) will never stop until they possess high biocompatibility and patency comparable to autologous native blood vessels. Integrating biocompatible electrospinning (ES) matrices with highly bioactive stem cells (SCs) provides a rational and promising solution. ES is a simple, fast, flexible and universal technology to prepare extracellular matrix-like fibrous scaffolds in large scale, while SCs are valuable, multifunctional and favorable seed cells with special characteristics for the emerging field of cell therapy and regenerative medicine. Both ES matrices and SCs are advanced resources with medical application prospects, and the combination may share their advantages to drive the overcoming of the long-lasting hurdles in SDVG field. In this review, the advances on SDVGs based on ES matrices and SCs (including pluripotent SCs, multipotent SCs, and unipotent SCs) are sorted out, and current challenges and future prospects are discussed.

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Section: Discussionmentioning

confidence: 99%