Nanoparticle as the Strategy for the Development of Sars-Cov-2 Antiviral Drugs

Abstract

In just a matter of months, SARS-CoV-2 had spread around the world. Scientists collaborate to solve the problem. The development of antiviral drugs is a challenge in itself due to the rapidly changing nature of the virus. Selection of drug candidates can be done quickly through the repurposing drug method. Broad-spectrum antiviral drugs may be strong candidates for SARS-CoV-2 therapy. Nanotechnology is one solution in the development of antiviral drug delivery systems. The advantages possessed by the nanoparticle system can answer the need for an ideal antiviral drug. This article will focus on the development of nanoparticle preparations as a strategy in handling viruses, including SARS-CoV-2. The selection of article for the current review was searched from specialized databases such as Elsevier, Pubmed, Science Direct, Medscape and other credible databases using the keywords nanoparticle, SARS-CoV-2, Covid-19, drug repurposing, polymeric nanoparticle, micelle, liposome, solid lipid nanoparticle, nanostructured lipid carrier, dendrimer, metallic nanoparticle. The range of articles was 2007–2021.

Phytochemical Analysis Both of Water and Ethanol Extract from Some Herbs Combinations, Nanoemulsion Formulation, and Antioxidant Effects

“…Therefore, this study continues to examine the activities of each herbal extract and its nanoemulsion product as an immunomodulator that can improve the body's immune system in overcoming the COVID-19 virus. Nanoparticles are a drug delivery system suitable for use in antiviral drugs, including those to treat SARS-CoV-2, so that effective antiviral drugs can be produced and without side effects [24]. Formulation of herbal extracts in the form of nanoemulsions will increase bioavailability, such as the results of research on curcumin nanoparticles formulated using beta-carotene and Poly-Lactic-co-Glicolyc Acid [25].…”

Nanotechnology and COVID-19: Prevention, diagnosis, vaccine, and treatment strategies

“…Dendrimers with compact spherical structure and highly branched 3D structures have unique physicochemical properties such as solubility, low polydispersity, effective drug encapsulation capacity (Jana et al, 2019;Witika et al, 2020;Mazayen et al, 2022), biodegradability, and biocompatibility (Paull et al, 2020;Khaitov et al, 2021). The ability of dendrimers to form strong interactions with viruses may increase antiviral activity, making them promising systems against viral infections (Yuliani, 2021;Zhang D. et al, 2021;Zhang et al, 2022). Composed of synthetic or natural phospholipids, cholesterol, and sphingolipids, liposomes are bilayer structures used for drug delivery (Abhyankar et al, 2021;Refaat et al, 2021;Thi et al, 2021).…”