Nanoparticle-based delivery systems as emerging therapy in retinoblastoma: recent advances, challenges and prospects

Onugwu, Adaeze Linda; Ugorji, Onyinyechi Lydia; Ufondu, Chinasa A.; Ihim, Stella Amarachi; Echezona, Adaeze Chidiebere; Nwagwu, Chinekwu Sherridan; Onugwu, Sabastine Obinna; Uzondu, Samuel WisdomofGod; Agbo, Chinazom Precious; Ogbonna, John Dike; Attama, Anthony Amaechi

doi:10.1039/d3na00462g

Cited by 7 publications

(1 citation statement)

References 157 publications

(268 reference statements)

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“…Their unique nanoscale size range, morphology, and biological properties help to improve the solubility, absorption, in vivo stability, site-specific delivery, release, toxicity, and cellular uptake of the drug. 35,36 Their compositions, shapes, sizes, and surfaces can be easily modified to achieve the desired therapeutic effects. 37 Surface modification by coating with polymeric materials or attachment of ligands or functional groups enhances their pharmacokinetic and biodistribution profiles.…”

Section: Nanocarriers In Drug Deliverymentioning

confidence: 99%

Bacteriophages as nanocarriers for targeted drug delivery and enhanced therapeutic effects

Emencheta,

Onugwu,

Kalu

et al. 2024

Mater. Adv.

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Section: Nanocarriers In Drug Deliverymentioning

confidence: 99%

Bacteriophages as nanocarriers for targeted drug delivery and enhanced therapeutic effects

Emencheta,

Onugwu,

Kalu

et al. 2024

Mater. Adv.

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Bioengineered carbohydrate polymers for colon‐specific drug release: Current trends and future prospects

Bhirud,

Bhattacharya,

Prajapati

2024

J Biomedical Materials Res

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The worldwide health burden of colorectal cancer is still substantial, and traditional chemotherapeutic drugs sometimes have poor selectivity, which can result in systemic toxicity and unfavorable side effects. For colon‐specific medication delivery, bioengineered carbohydrate polymers have shown promise as carriers. They may enhance treatment effectiveness while minimizing systemic exposure and associated side effects. The unique properties of these manufactured or naturally occurring biopolymers, such as hyaluronic acid, chitosan, alginate, and pectin, enable targeted medicine release. These qualities can be changed to meet the physiological needs of the colon. In the context of colorectal cancer therapy, this article provides a comprehensive overview of current developments and prospective future directions in the field of bioengineered carbohydrate polymer synthesis for colon‐specific drug delivery. We discuss numerous techniques for achieving colon‐targeted drug release, including enzyme‐sensitive polymers, pH‐responsive devices, and microbiota‐activated processes. To increase tumor selectivity and cellular uptake, we also examine the inclusion of active targeting approaches, such as conjugating specific ligands. Furthermore, we discuss the potential of combination treatment strategies, which use the coadministration of numerous therapeutic medications to target multiple pathways implicated in cancer growth and address drug resistance mechanisms. We address recent biomimetic advances that potentially improve the biocompatibility, cellular uptake, and tumor penetration of carbohydrate polymer‐based nanocarriers. These methods involve protein corona engineering and cell membrane coating. Furthermore, we look at the possibility of intelligent and sensitive systems that may adjust their behaviors in response to certain inputs or feedback loops, allowing for precise and regulated drug distribution.

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Synthesis and electrochemical properties of CuCo2O4@Co3O4 nanocomposite for supercapacitor application

Thali,

Kamble

2024

J Solid State Electrochem

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Nanoparticle-based delivery systems as emerging therapy in retinoblastoma: recent advances, challenges and prospects

Abstract: Retinoblastoma is the most common intraocular malignancy in children. The treatment of this rare disease is still challenging in developing countries due to delayed diagnosis. The current therapies comprise mainly...

Cited by 7 publications

References 157 publications

Bacteriophages as nanocarriers for targeted drug delivery and enhanced therapeutic effects

Bacteriophages as nanocarriers for targeted drug delivery and enhanced therapeutic effects

Bioengineered carbohydrate polymers for colon‐specific drug release: Current trends and future prospects

Synthesis and electrochemical properties of CuCo2O4@Co3O4 nanocomposite for supercapacitor application

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